# Adaptive Mix for Semi-Supervised Medical Image Segmentation

arXiv: https://arxiv.org/abs/2407.21586 · HTML: https://mlsanity.com/paper/2407.21586/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 60 of its 87 references that are in the map.
- First posted on arXiv 31 Jul 2024.

## Builds on (most cited first, 30 of 60)

- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [mixup: Beyond Empirical Risk Minimization](https://mlsanity.com/paper/1710.09412/) (2017)
- [Fully Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1411.4038/) (2014)
- [CutMix: Regularization Strategy to Train Strong Classifiers with Localizable Features](https://mlsanity.com/paper/1905.04899/) (2019)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [FixMatch: Simplifying Semi-Supervised Learning with Consistency and Confidence](https://mlsanity.com/paper/2001.07685/) (2020)
- [Improved Regularization of Convolutional Neural Networks with Cutout](https://mlsanity.com/paper/1708.04552/) (2017)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [MixMatch: A Holistic Approach to Semi-Supervised Learning](https://mlsanity.com/paper/1905.02249/) (2019)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [Optimization Methods for Large-Scale Machine Learning](https://mlsanity.com/paper/1606.04838/) (2016)
- [Temporal Ensembling for Semi-Supervised Learning](https://mlsanity.com/paper/1610.02242/) (2016)
- [A Closer Look at Memorization in Deep Networks](https://mlsanity.com/paper/1706.05394/) (2017)
- [Virtual Adversarial Training: A Regularization Method for Supervised and Semi-Supervised Learning](https://mlsanity.com/paper/1704.03976/) (2017)
- [FlexMatch: Boosting Semi-Supervised Learning with Curriculum Pseudo Labeling](https://mlsanity.com/paper/2110.08263/) (2021)
- [Semi-Supervised Semantic Segmentation with Cross Pseudo Supervision](https://mlsanity.com/paper/2106.01226/) (2021)
- [Uncertainty-aware Self-ensembling Model for Semi-supervised 3D Left Atrium Segmentation](https://mlsanity.com/paper/1907.07034/) (2019)
- [ReMixMatch: Semi-Supervised Learning with Distribution Alignment and Augmentation Anchoring](https://mlsanity.com/paper/1911.09785/) (2019)
- [Medical Transformer: Gated Axial-Attention for Medical Image Segmentation](https://mlsanity.com/paper/2102.10662/) (2021)
- [SegMamba: Long-range Sequential Modeling Mamba For 3D Medical Image Segmentation](https://mlsanity.com/paper/2401.13560/) (2024)
- [Puzzle Mix: Exploiting Saliency and Local Statistics for Optimal Mixup](https://mlsanity.com/paper/2009.06962/) (2020)
- [Interpolation Consistency Training for Semi-Supervised Learning](https://mlsanity.com/paper/1903.03825/) (2019)
- [Semi-Supervised Learning with Ladder Networks](https://mlsanity.com/paper/1507.02672/) (2015)
- [FreeMatch: Self-adaptive Thresholding for Semi-supervised Learning](https://mlsanity.com/paper/2205.07246/) (2022)
- [Segment Anything in Medical Images](https://mlsanity.com/paper/2304.12306/) (2023)

## Built on by (most cited first, 1 of 1)

- [Beyond Random Sampling: Distribution-Aware Alignment for Semi-Supervised Medical Image Segmentation](https://mlsanity.com/paper/2607.04249/) (2026)

## Abstract (arXiv)

Mix-up is a key technique for consistency regularization-based semi-supervised learning methods, blending two or more images to generate strong-perturbed samples for strong-weak pseudo supervision. Existing mix-up operations are performed either randomly or with predefined fixed rules, such as replacing low-confidence patches with high-confidence ones. The former lacks control over the perturbation degree, leading to overfitting on randomly perturbed samples, while the latter tends to generate images with trivial perturbations, both of which limit the effectiveness of consistency regularization. This paper aims to answer the following question: How can image mix-up perturbation be adaptively performed during training? To this end, we propose an Adaptive Mix algorithm (AdaMix) for image mix-up in a self-paced learning manner. Given that, in general, a model's performance gradually improves during training, AdaMix is equipped with a self-paced curriculum that, in the initial training stage, provides relatively simple perturbed samples and then gradually increases the difficulty of perturbed images by adaptively controlling the perturbation degree based on the model's learning state estimated by a self-paced regularize. We develop three frameworks with our AdaMix, i.e., AdaMix-ST, AdaMix-MT, and AdaMix-CT, for semi-supervised medical image segmentation. Extensive experiments on three public datasets show that the proposed frameworks can achieve superior performance. For example, compared with the state-of-the-art, AdaMix-CT achieves relative improvements of 2.62% in Dice similarity coefficient and 48.25% in average surface distance on the ACDC dataset with 10% labeled data. The results demonstrate that mix-up operations with dynamically adjusted perturbation strength based on the segmentation model's state can significantly enhance the effectiveness of consistency regularization.