# LKCell: Efficient Cell Nuclei Instance Segmentation with Large Convolution Kernels

arXiv: https://arxiv.org/abs/2407.18054 · HTML: https://mlsanity.com/paper/2407.18054/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 26 of its 36 references that are in the map.
- First posted on arXiv 25 Jul 2024.

## Builds on (most cited first, 26 of 26)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [Mask R-CNN](https://mlsanity.com/paper/1703.06870/) (2017)
- [Training data-efficient image transformers & distillation through attention](https://mlsanity.com/paper/2012.12877/) (2020)
- [MobileNets: Efficient Convolutional Neural Networks for Mobile Vision Applications](https://mlsanity.com/paper/1704.04861/) (2017)
- [A ConvNet for the 2020s](https://mlsanity.com/paper/2201.03545/) (2022)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [ConvNeXt V2: Co-designing and Scaling ConvNets with Masked Autoencoders](https://mlsanity.com/paper/2301.00808/) (2023)
- [RepVGG: Making VGG-style ConvNets Great Again](https://mlsanity.com/paper/2101.03697/) (2021)
- [HoVer-Net: Simultaneous Segmentation and Classification of Nuclei in Multi-Tissue Histology Images](https://mlsanity.com/paper/1812.06499/) (2018)
- [Cell Detection with Star-convex Polygons](https://mlsanity.com/paper/1806.03535/) (2018)
- [PanNuke Dataset Extension, Insights and Baselines](https://mlsanity.com/paper/2003.10778/) (2020)
- [CellViT: Vision Transformers for Precise Cell Segmentation and Classification](https://mlsanity.com/paper/2306.15350/) (2023)
- [UniRepLKNet: A Universal Perception Large-Kernel ConvNet for Audio, Video, Point Cloud, Time-Series and Image Recognition](https://mlsanity.com/paper/2311.15599/) (2023)
- [Micro-Net: A unified model for segmentation of various objects in microscopy images](https://mlsanity.com/paper/1804.08145/) (2018)
- [CPP-Net: Context-aware Polygon Proposal Network for Nucleus Segmentation](https://mlsanity.com/paper/2102.06867/) (2021)
- [Beyond Self-Attention: Deformable Large Kernel Attention for Medical Image Segmentation](https://mlsanity.com/paper/2309.00121/) (2023)
- [Segment Any Cell: A SAM-based Auto-prompting Fine-tuning Framework for Nuclei Segmentation](https://mlsanity.com/paper/2401.13220/) (2024)
- [MaxViT-UNet: Multi-Axis Attention for Medical Image Segmentation](https://mlsanity.com/paper/2305.08396/) (2023)
- [HoVer-UNet: Accelerating HoVerNet with UNet-based multi-class nuclei segmentation via knowledge distillation](https://mlsanity.com/paper/2311.12553/) (2023)
- [Valuing Vicinity: Memory attention framework for context-based semantic segmentation in histopathology](https://mlsanity.com/paper/2210.11822/) (2022)

## Built on by (most cited first, 3 of 3)

- [UniX: Unifying Autoregression and Diffusion for Chest X-Ray Understanding and Generation](https://mlsanity.com/paper/2601.11522/) (2026)
- [Sketchpose: Learning to Segment Cells with Partial Annotations](https://mlsanity.com/paper/2508.17798/) (2025)
- [LSP-DETR: Efficient and Scalable Nuclei Segmentation in Whole-Slide Images](https://mlsanity.com/paper/2601.03163/) (2026)

## Abstract (arXiv)

The segmentation of cell nuclei in tissue images stained with the blood dye hematoxylin and eosin (H&E) is essential for various clinical applications and analyses. Due to the complex characteristics of cellular morphology, a large receptive field is considered crucial for generating high-quality segmentation. However, previous methods face challenges in achieving a balance between the receptive field and computational burden. To address this issue, we propose LKCell, a high-accuracy and efficient cell segmentation method. Its core insight lies in unleashing the potential of large convolution kernels to achieve computationally efficient large receptive fields. Specifically, (1) We transfer pre-trained large convolution kernel models to the medical domain for the first time, demonstrating their effectiveness in cell segmentation. (2) We analyze the redundancy of previous methods and design a new segmentation decoder based on large convolution kernels. It achieves higher performance while significantly reducing the number of parameters. We evaluate our method on the most challenging benchmark and achieve state-of-the-art results (0.5080 mPQ) in cell nuclei instance segmentation with only 21.6% FLOPs compared with the previous leading method. Our source code and models are available at https://github.com/hustvl/LKCell.