# GFE-Mamba: Mamba-based AD Multi-modal Progression Assessment via Generative Feature Extraction from MCI

arXiv: https://arxiv.org/abs/2407.15719 · HTML: https://mlsanity.com/paper/2407.15719/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Placed in Mamba for medical image analysis, one of 10 directions in State-space sequence models (S4, Mamba).
- Builds on 8 of its 51 references that are in the map.
- First posted on arXiv 22 Jul 2024.

## Placed in

- State-space sequence models (S4, Mamba) / [Mamba for medical image analysis](https://mlsanity.com/ssm/mamba-for-medical-image-analysis/)

## Builds on (most cited first, 8 of 8)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Revisiting Deep Learning Models for Tabular Data](https://mlsanity.com/paper/2106.11959/) (2021)
- [TabTransformer: Tabular Data Modeling Using Contextual Embeddings](https://mlsanity.com/paper/2012.06678/) (2020)
- [RadFusion: Benchmarking Performance and Fairness for Multimodal Pulmonary Embolism Detection from CT and EHR](https://mlsanity.com/paper/2111.11665/) (2021)
- [Deep Learning in Alzheimer's disease: Diagnostic Classification and Prognostic Prediction using Neuroimaging Data](https://mlsanity.com/paper/1905.00931/) (2019)
- [Cascaded Multi-Modal Mixing Transformers for Alzheimer's Disease Classification with Incomplete Data](https://mlsanity.com/paper/2210.00255/) (2022)
- [DecGAN: Decoupling Generative Adversarial Network detecting abnormal neural circuits for Alzheimer's disease](https://mlsanity.com/paper/2110.05712/) (2021)
- [ASMFS: Adaptive-Similarity-based Multi-modality Feature Selection for Classification of Alzheimer's Disease](https://mlsanity.com/paper/2010.08190/) (2020)

## Built on by (most cited first, 4 of 4)

- [A Comprehensive Survey of Mamba Architectures for Medical Image Analysis: Classification, Segmentation, Restoration and Beyond](https://mlsanity.com/paper/2410.02362/) (2024)
- [Toward Robust Early Detection of Alzheimer's Disease via an Integrated Multimodal Learning Approach](https://mlsanity.com/paper/2408.16343/) (2024)
- [AlzheimerRAG: Multimodal Retrieval Augmented Generation for Clinical Use Cases using PubMed articles](https://mlsanity.com/paper/2412.16701/) (2024)
- [ITCFN: Incomplete Triple-Modal Co-Attention Fusion Network for Mild Cognitive Impairment Conversion Prediction](https://mlsanity.com/paper/2501.11276/) (2025)

## Abstract (arXiv)

Alzheimer's Disease (AD) is a progressive, irreversible neurodegenerative disorder that often originates from Mild Cognitive Impairment (MCI). This progression results in significant memory loss and severely affects patients' quality of life. Clinical trials have consistently shown that early and targeted interventions for individuals with MCI may slow or even prevent the advancement of AD. Research indicates that accurate medical classification requires diverse multimodal data, including detailed assessment scales and neuroimaging techniques like Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET). However, simultaneously collecting the aforementioned three modalities for training presents substantial challenges. To tackle these difficulties, we propose GFE-Mamba, a multimodal classifier founded on Generative Feature Extractor. The intermediate features provided by this Extractor can compensate for the shortcomings of PET and achieve profound multimodal fusion in the classifier. The Mamba block, as the backbone of the classifier, enables it to efficiently extract information from long-sequence scale information. Pixel-level Bi-cross Attention supplements pixel-level information from MRI and PET. We provide our rationale for developing this cross-temporal progression prediction dataset and the pre-trained Extractor weights. Our experimental findings reveal that the GFE-Mamba model effectively predicts the progression from MCI to AD and surpasses several leading methods in the field. Our source code is available at https://github.com/Tinysqua/GFE-Mamba.