# Understanding Reinforcement Learning-Based Fine-Tuning of Diffusion Models: A Tutorial and Review

arXiv: https://arxiv.org/abs/2407.13734 · HTML: https://mlsanity.com/paper/2407.13734/

## Key facts

- Cited by 98 papers in the map (data through 14 Oct 2026).
- Placed in Diffusion and flow policies for robotics, one of 14 directions in Diffusion models.
- Builds on 87 of its 110 references that are in the map.
- First posted on arXiv 18 Jul 2024.

## Placed in

- Diffusion models / [Diffusion and flow policies for robotics](https://mlsanity.com/diffusion/diffusion-and-flow-policies-for-robotics/)
- Deep reinforcement learning methods / [RL with diffusion and flow models](https://mlsanity.com/deeprl/rl-with-diffusion-and-flow-models/)

## Builds on (most cited first, 30 of 87)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Proximal Policy Optimization Algorithms](https://mlsanity.com/paper/1707.06347/) (2017)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Flow Matching for Generative Modeling](https://mlsanity.com/paper/2210.02747/) (2022)
- [SDXL: Improving Latent Diffusion Models for High-Resolution Image Synthesis](https://mlsanity.com/paper/2307.01952/) (2023)
- [Neural Ordinary Differential Equations](https://mlsanity.com/paper/1806.07366/) (2018)
- [Flow Straight and Fast: Learning to Generate and Transfer Data with Rectified Flow](https://mlsanity.com/paper/2209.03003/) (2022)
- [Constitutional AI: Harmlessness from AI Feedback](https://mlsanity.com/paper/2212.08073/) (2022)
- [Trust Region Policy Optimization](https://mlsanity.com/paper/1502.05477/) (2015)
- [Video Diffusion Models](https://mlsanity.com/paper/2204.03458/) (2022)
- [Conservative Q-Learning for Offline Reinforcement Learning](https://mlsanity.com/paper/2006.04779/) (2020)
- [Structured Denoising Diffusion Models in Discrete State-Spaces](https://mlsanity.com/paper/2107.03006/) (2021)
- [Diffusion Posterior Sampling for General Noisy Inverse Problems](https://mlsanity.com/paper/2209.14687/) (2022)
- [Diffusion Models: A Comprehensive Survey of Methods and Applications](https://mlsanity.com/paper/2209.00796/) (2022)
- [Planning with Diffusion for Flexible Behavior Synthesis](https://mlsanity.com/paper/2205.09991/) (2022)
- [Building Normalizing Flows with Stochastic Interpolants](https://mlsanity.com/paper/2209.15571/) (2022)
- [Training Diffusion Models with Reinforcement Learning](https://mlsanity.com/paper/2305.13301/) (2023)
- [Diffusion Model Alignment Using Direct Preference Optimization](https://mlsanity.com/paper/2311.12908/) (2023)
- [Advantage-Weighted Regression: Simple and Scalable Off-Policy Reinforcement Learning](https://mlsanity.com/paper/1910.00177/) (2019)
- [Open Problems and Fundamental Limitations of Reinforcement Learning from Human Feedback](https://mlsanity.com/paper/2307.15217/) (2023)
- [Equivariant Diffusion for Molecule Generation in 3D](https://mlsanity.com/paper/2203.17003/) (2022)
- [Maximum Likelihood Training of Score-Based Diffusion Models](https://mlsanity.com/paper/2101.09258/) (2021)
- [Reinforcement Learning with Deep Energy-Based Policies](https://mlsanity.com/paper/1702.08165/) (2017)
- [Behavior Regularized Offline Reinforcement Learning](https://mlsanity.com/paper/1911.11361/) (2019)

## Built on by (most cited first, 30 of 98)

- [Adjoint Matching: Fine-tuning Flow and Diffusion Generative Models with Memoryless Stochastic Optimal Control](https://mlsanity.com/paper/2409.08861/) (2024)
- [Derivative-Free Guidance in Continuous and Discrete Diffusion Models with Soft Value-Based Decoding](https://mlsanity.com/paper/2408.08252/) (2024)
- [Feynman-Kac Correctors in Diffusion: Annealing, Guidance, and Product of Experts](https://mlsanity.com/paper/2503.02819/) (2025)
- [Inference-Time Alignment in Diffusion Models with Reward-Guided Generation: Tutorial and Review](https://mlsanity.com/paper/2501.09685/) (2025)
- [Fine-Tuning Discrete Diffusion Models via Reward Optimization with Applications to DNA and Protein Design](https://mlsanity.com/paper/2410.13643/) (2024)
- [Policy Decorator: Model-Agnostic Online Refinement for Large Policy Model](https://mlsanity.com/paper/2412.13630/) (2024)
- [Gen-Drive: Enhancing Diffusion Generative Driving Policies with Reward Modeling and Reinforcement Learning Fine-tuning](https://mlsanity.com/paper/2410.05582/) (2024)
- [Scaling Image and Video Generation via Test-Time Evolutionary Search](https://mlsanity.com/paper/2505.17618/) (2025)
- [Align Anything: Training All-Modality Models to Follow Instructions with Language Feedback](https://mlsanity.com/paper/2412.15838/) (2024)
- [Fine-Tuning Discrete Diffusion Models with Policy Gradient Methods](https://mlsanity.com/paper/2502.01384/) (2025)
- [Dynamic Search for Inference-Time Alignment in Diffusion Models](https://mlsanity.com/paper/2503.02039/) (2025)
- [Alignment of Diffusion Models: Fundamentals, Challenges, and Future](https://mlsanity.com/paper/2409.07253/) (2024)
- [Steering Masked Discrete Diffusion Models via Discrete Denoising Posterior Prediction](https://mlsanity.com/paper/2410.08134/) (2024)
- [Training-Free Guidance Beyond Differentiability: Scalable Path Steering with Tree Search in Diffusion and Flow Models](https://mlsanity.com/paper/2502.11420/) (2025)
- [Preference Tuning with Human Feedback on Language, Speech, and Vision Tasks: A Survey](https://mlsanity.com/paper/2409.11564/) (2024)
- [Scores as Actions: a framework of fine-tuning diffusion models by continuous-time reinforcement learning](https://mlsanity.com/paper/2409.08400/) (2024)
- [Stochastic Control for Fine-tuning Diffusion Models: Optimality, Regularity, and Convergence](https://mlsanity.com/paper/2412.18164/) (2024)
- [GARDO: Reinforcing Diffusion Models without Reward Hacking](https://mlsanity.com/paper/2512.24138/) (2025)
- [Reward Fine-Tuning Two-Step Diffusion Models via Learning Differentiable Latent-Space Surrogate Reward](https://mlsanity.com/paper/2411.15247/) (2024)
- [Psi-Sampler: Initial Particle Sampling for SMC-Based Inference-Time Reward Alignment in Score Models](https://mlsanity.com/paper/2506.01320/) (2025)
- [Optimizing Backward Policies in GFlowNets via Trajectory Likelihood Maximization](https://mlsanity.com/paper/2410.15474/) (2024)
- [CoDe: Blockwise Control for Denoising Diffusion Models](https://mlsanity.com/paper/2502.00968/) (2025)
- [TR2-D2: Tree Search Guided Trajectory-Aware Fine-Tuning for Discrete Diffusion](https://mlsanity.com/paper/2509.25171/) (2025)
- [Conditional Diffusion Guidance under Hard Constraint: A Stochastic Analysis Approach](https://mlsanity.com/paper/2602.05533/) (2026)
- [Discrete Adjoint Matching](https://mlsanity.com/paper/2602.07132/) (2026)
- [Training-Free Adaptation of Diffusion Models via Doob's h-Transform](https://mlsanity.com/paper/2602.16198/) (2026)
- [Revisiting Non-Acyclic GFlowNets in Discrete Environments](https://mlsanity.com/paper/2502.07735/) (2025)
- [Composition and Alignment of Diffusion Models using Constrained Learning](https://mlsanity.com/paper/2508.19104/) (2025)
- [Free2Guide: Training-Free Text-to-Video Alignment using Image LVLM](https://mlsanity.com/paper/2411.17041/) (2024)
- [MIRA: Towards Mitigating Reward Hacking in Inference-Time Alignment of T2I Diffusion Models](https://mlsanity.com/paper/2510.01549/) (2025)

## Abstract (arXiv)

This tutorial provides a comprehensive survey of methods for fine-tuning diffusion models to optimize downstream reward functions. While diffusion models are widely known to provide excellent generative modeling capability, practical applications in domains such as biology require generating samples that maximize some desired metric (e.g., translation efficiency in RNA, docking score in molecules, stability in protein). In these cases, the diffusion model can be optimized not only to generate realistic samples but also to explicitly maximize the measure of interest. Such methods are based on concepts from reinforcement learning (RL). We explain the application of various RL algorithms, including PPO, differentiable optimization, reward-weighted MLE, value-weighted sampling, and path consistency learning, tailored specifically for fine-tuning diffusion models. We aim to explore fundamental aspects such as the strengths and limitations of different RL-based fine-tuning algorithms across various scenarios, the benefits of RL-based fine-tuning compared to non-RL-based approaches, and the formal objectives of RL-based fine-tuning (target distributions). Additionally, we aim to examine their connections with related topics such as classifier guidance, Gflownets, flow-based diffusion models, path integral control theory, and sampling from unnormalized distributions such as MCMC. The code of this tutorial is available at https://github.com/masa-ue/RLfinetuning_Diffusion_Bioseq