# DiffuX2CT: Diffusion Learning to Reconstruct CT Images from Biplanar X-Rays

arXiv: https://arxiv.org/abs/2407.13545 · HTML: https://mlsanity.com/paper/2407.13545/

## Key facts

- Cited by 9 papers in the map (data through 14 Oct 2026).
- Builds on 65 of its 92 references that are in the map.
- First posted on arXiv 18 Jul 2024.

## Builds on (most cited first, 30 of 65)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding](https://mlsanity.com/paper/2205.11487/) (2022)
- [Scalable Diffusion Models with Transformers](https://mlsanity.com/paper/2212.09748/) (2022)
- [Auto-Encoding Variational Bayes](https://mlsanity.com/paper/1312.6114/) (2013)
- [GLIDE: Towards Photorealistic Image Generation and Editing with Text-Guided Diffusion Models](https://mlsanity.com/paper/2112.10741/) (2021)
- [DreamFusion: Text-to-3D using 2D Diffusion](https://mlsanity.com/paper/2209.14988/) (2022)
- [DeepSDF: Learning Continuous Signed Distance Functions for Shape Representation](https://mlsanity.com/paper/1901.05103/) (2019)
- [Video Diffusion Models](https://mlsanity.com/paper/2204.03458/) (2022)
- [Implicit Neural Representations with Periodic Activation Functions](https://mlsanity.com/paper/2006.09661/) (2020)
- [Mip-NeRF: A Multiscale Representation for Anti-Aliasing Neural Radiance Fields](https://mlsanity.com/paper/2103.13415/) (2021)
- [Imagen Video: High Definition Video Generation with Diffusion Models](https://mlsanity.com/paper/2210.02303/) (2022)
- [ViViT: A Video Vision Transformer](https://mlsanity.com/paper/2103.15691/) (2021)
- [Image Super-Resolution via Iterative Refinement](https://mlsanity.com/paper/2104.07636/) (2021)
- [Align your Latents: High-Resolution Video Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2304.08818/) (2023)
- [DiffWave: A Versatile Diffusion Model for Audio Synthesis](https://mlsanity.com/paper/2009.09761/) (2020)
- [Magic3D: High-Resolution Text-to-3D Content Creation](https://mlsanity.com/paper/2211.10440/) (2022)
- [ProlificDreamer: High-Fidelity and Diverse Text-to-3D Generation with Variational Score Distillation](https://mlsanity.com/paper/2305.16213/) (2023)
- [Efficient Geometry-aware 3D Generative Adversarial Networks](https://mlsanity.com/paper/2112.07945/) (2021)
- [Human Motion Diffusion Model](https://mlsanity.com/paper/2209.14916/) (2022)
- [Learning Implicit Fields for Generative Shape Modeling](https://mlsanity.com/paper/1812.02822/) (2018)
- [Tune-A-Video: One-Shot Tuning of Image Diffusion Models for Text-to-Video Generation](https://mlsanity.com/paper/2212.11565/) (2022)
- [Diffusion Probabilistic Models for 3D Point Cloud Generation](https://mlsanity.com/paper/2103.01458/) (2021)
- [pi-GAN: Periodic Implicit Generative Adversarial Networks for 3D-Aware Image Synthesis](https://mlsanity.com/paper/2012.00926/) (2020)

## Built on by (most cited first, 9 of 9)

- [DVG-Diffusion: Dual-View Guided Diffusion Model for CT Reconstruction from X-Rays](https://mlsanity.com/paper/2503.17804/) (2025)
- [Bidirectional Mammogram View Translation with Column-Aware and Implicit 3D Conditional Diffusion](https://mlsanity.com/paper/2510.04947/) (2025)
- [Exploiting Completeness Perception with Diffusion Transformer for Unified 3D MRI Synthesis](https://mlsanity.com/paper/2602.18400/) (2026)
- [ReBrain: Brain MRI Reconstruction from Sparse CT Slice via Retrieval-Augmented Diffusion](https://mlsanity.com/paper/2511.17068/) (2025)
- [DuFal: Dual-Frequency-Aware Learning for High-Fidelity Extremely Sparse-view CBCT Reconstruction](https://mlsanity.com/paper/2601.15416/) (2026)
- [Conditional Diffusion for 3D CT Volume Reconstruction from 2D X-rays](https://mlsanity.com/paper/2603.26509/) (2026)
- [PSCT-Net: Geometry-Aware Pediatric Skull CT Reconstruction via Differentiable Back-Projection and Attention-Guided Refinement](https://mlsanity.com/paper/2606.19867/) (2026)
- [From Sparse X-rays to 3D CT: Training-Free Reconstruction with Diffusion Priors](https://mlsanity.com/paper/2606.20763/) (2026)
- [Learning Where and What to Lift for Bi-planar X-ray-to-CT Reconstruction](https://mlsanity.com/paper/2608.17255/) (2026)

## Abstract (arXiv)

Computed tomography (CT) is widely utilized in clinical settings because it delivers detailed 3D images of the human body. However, performing CT scans is not always feasible due to radiation exposure and limitations in certain surgical environments. As an alternative, reconstructing CT images from ultra-sparse X-rays offers a valuable solution and has gained significant interest in scientific research and medical applications. However, it presents great challenges as it is inherently an ill-posed problem, often compromised by artifacts resulting from overlapping structures in X-ray images. In this paper, we propose DiffuX2CT, which models CT reconstruction from orthogonal biplanar X-rays as a conditional diffusion process. DiffuX2CT is established with a 3D global coherence denoising model with a new, implicit conditioning mechanism. We realize the conditioning mechanism by a newly designed tri-plane decoupling generator and an implicit neural decoder. By doing so, DiffuX2CT achieves structure-controllable reconstruction, which enables 3D structural information to be recovered from 2D X-rays, therefore producing faithful textures in CT images. As an extra contribution, we collect a real-world lumbar CT dataset, called LumbarV, as a new benchmark to verify the clinical significance and performance of CT reconstruction from X-rays. Extensive experiments on this dataset and three more publicly available datasets demonstrate the effectiveness of our proposal.