# LAB-Bench: Measuring Capabilities of Language Models for Biology Research

arXiv: https://arxiv.org/abs/2407.10362 · HTML: https://mlsanity.com/paper/2407.10362/

## Key facts

- Cited by 156 papers in the map (data through 14 Oct 2026).
- Builds on 12 of its 48 references that are in the map.
- First posted on arXiv 14 Jul 2024.

## Builds on (most cited first, 12 of 12)

- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [GPQA: A Graduate-Level Google-Proof Q&A Benchmark](https://mlsanity.com/paper/2311.12022/) (2023)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [Can LLMs Express Their Uncertainty? An Empirical Evaluation of Confidence Elicitation in LLMs](https://mlsanity.com/paper/2306.13063/) (2023)
- [Large Language Models](https://mlsanity.com/paper/2307.05782/) (2023)
- [Galactica: A Large Language Model for Science](https://mlsanity.com/paper/2211.09085/) (2022)
- [ChemCrow: Augmenting large-language models with chemistry tools](https://mlsanity.com/paper/2304.05376/) (2023)
- [Large Language Models Are Not Robust Multiple Choice Selectors](https://mlsanity.com/paper/2309.03882/) (2023)
- [Repeat After Me: Transformers are Better than State Space Models at Copying](https://mlsanity.com/paper/2402.01032/) (2024)
- [Lessons from the Trenches on Reproducible Evaluation of Language Models](https://mlsanity.com/paper/2405.14782/) (2024)
- [GeneGPT: Augmenting Large Language Models with Domain Tools for Improved Access to Biomedical Information](https://mlsanity.com/paper/2304.09667/) (2023)
- [Machine Learning with a Reject Option: A survey](https://mlsanity.com/paper/2107.11277/) (2021)

## Built on by (most cited first, 30 of 156)

- [GPT-4o System Card](https://mlsanity.com/paper/2410.21276/) (2024)
- [gpt-oss-120b & gpt-oss-20b Model Card](https://mlsanity.com/paper/2508.10925/) (2025)
- [OpenAI o1 System Card](https://mlsanity.com/paper/2412.16720/) (2024)
- [Humanity's Last Exam](https://mlsanity.com/paper/2501.14249/) (2025)
- [DeepResearch Bench: A Comprehensive Benchmark for Deep Research Agents](https://mlsanity.com/paper/2506.11763/) (2025)
- [Survey on Evaluation of LLM-based Agents](https://mlsanity.com/paper/2503.16416/) (2025)
- [Language agents achieve superhuman synthesis of scientific knowledge](https://mlsanity.com/paper/2409.13740/) (2024)
- [Towards Scientific Intelligence: A Survey of LLM-based Scientific Agents](https://mlsanity.com/paper/2503.24047/) (2025)
- [BixBench: a Comprehensive Benchmark for LLM-based Agents in Computational Biology](https://mlsanity.com/paper/2503.00096/) (2025)
- [Agentic AI for Scientific Discovery: A Survey of Progress, Challenges, and Future Directions](https://mlsanity.com/paper/2503.08979/) (2025)
- [SHADE-Arena: Evaluating Sabotage and Monitoring in LLM Agents](https://mlsanity.com/paper/2506.15740/) (2025)
- [A Survey of Agentic Reasoning for Large Language Models: Towards Recursively Self-Improving and Collective Agents](https://mlsanity.com/paper/2601.12538/) (2026)
- [Visual Agentic AI for Spatial Reasoning with a Dynamic API](https://mlsanity.com/paper/2502.06787/) (2025)
- [Transforming Science with Large Language Models: A Survey on AI-assisted Scientific Discovery, Experimentation, Content Generation, and Evaluation](https://mlsanity.com/paper/2502.05151/) (2025)
- [EXP-Bench: Can AI Conduct AI Research Experiments?](https://mlsanity.com/paper/2505.24785/) (2025)
- [A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers](https://mlsanity.com/paper/2508.21148/) (2025)
- [Evaluation data contamination in LLMs: how do we measure it and (when) does it matter?](https://mlsanity.com/paper/2411.03923/) (2024)
- [Probing the limitations of multimodal language models for chemistry and materials research](https://mlsanity.com/paper/2411.16955/) (2024)
- [MicroVQA: A Multimodal Reasoning Benchmark for Microscopy-Based Scientific Research](https://mlsanity.com/paper/2503.13399/) (2025)
- [Virology Capabilities Test (VCT): A Multimodal Virology Q&A Benchmark](https://mlsanity.com/paper/2504.16137/) (2025)
- [Aviary: training language agents on challenging scientific tasks](https://mlsanity.com/paper/2412.21154/) (2024)
- [DeepResearch Arena: The First Exam of LLMs' Research Abilities via Seminar-Grounded Tasks](https://mlsanity.com/paper/2509.01396/) (2025)
- [ToolUniverse: An open platform for democratizing AI scientists](https://mlsanity.com/paper/2509.23426/) (2025)
- [MDCrow: Automating Molecular Dynamics Workflows with Large Language Models](https://mlsanity.com/paper/2502.09565/) (2025)
- [Estimating Worst-Case Frontier Risks of Open-Weight LLMs](https://mlsanity.com/paper/2508.03153/) (2025)
- [RExBench: Can coding agents autonomously implement AI research extensions?](https://mlsanity.com/paper/2506.22598/) (2025)
- [LLMs Can Covertly Sandbag on Capability Evaluations Against Chain-of-Thought Monitoring](https://mlsanity.com/paper/2508.00943/) (2025)
- [Towards LLM Agents for Earth Observation](https://mlsanity.com/paper/2504.12110/) (2025)
- [BioProBench: A Corpus and Benchmark for Biological Protocol Reasoning in Autonomous Science](https://mlsanity.com/paper/2505.07889/) (2025)
- [Designing Domain-Specific Agents via Hierarchical Task Abstraction Mechanism](https://mlsanity.com/paper/2511.17198/) (2025)

## Abstract (arXiv)

There is widespread optimism that frontier Large Language Models (LLMs) and LLM-augmented systems have the potential to rapidly accelerate scientific discovery across disciplines. Today, many benchmarks exist to measure LLM knowledge and reasoning on textbook-style science questions, but few if any benchmarks are designed to evaluate language model performance on practical tasks required for scientific research, such as literature search, protocol planning, and data analysis. As a step toward building such benchmarks, we introduce the Language Agent Biology Benchmark (LAB-Bench), a broad dataset of over 2,400 multiple choice questions for evaluating AI systems on a range of practical biology research capabilities, including recall and reasoning over literature, interpretation of figures, access and navigation of databases, and comprehension and manipulation of DNA and protein sequences. Importantly, in contrast to previous scientific benchmarks, we expect that an AI system that can achieve consistently high scores on the more difficult LAB-Bench tasks would serve as a useful assistant for researchers in areas such as literature search and molecular cloning. As an initial assessment of the emergent scientific task capabilities of frontier language models, we measure performance of several against our benchmark and report results compared to human expert biology researchers. We will continue to update and expand LAB-Bench over time, and expect it to serve as a useful tool in the development of automated research systems going forward. A public subset of LAB-Bench is available for use at the following URL: https://huggingface.co/datasets/futurehouse/lab-bench