# Bora: Biomedical Generalist Video Generation Model

arXiv: https://arxiv.org/abs/2407.08944 · HTML: https://mlsanity.com/paper/2407.08944/

## Key facts

- Cited by 15 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 34 of its 55 references that are in the map.
- First posted on arXiv 12 Jul 2024.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 30 of 34)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding](https://mlsanity.com/paper/2205.11487/) (2022)
- [Stable Video Diffusion: Scaling Latent Video Diffusion Models to Large Datasets](https://mlsanity.com/paper/2311.15127/) (2023)
- [RAFT: Recurrent All-Pairs Field Transforms for Optical Flow](https://mlsanity.com/paper/2003.12039/) (2020)
- [VBench: Comprehensive Benchmark Suite for Video Generative Models](https://mlsanity.com/paper/2311.17982/) (2023)
- [Imagen Video: High Definition Video Generation with Diffusion Models](https://mlsanity.com/paper/2210.02303/) (2022)
- [Make-A-Video: Text-to-Video Generation without Text-Video Data](https://mlsanity.com/paper/2209.14792/) (2022)
- [Video-LLaMA: An Instruction-tuned Audio-Visual Language Model for Video Understanding](https://mlsanity.com/paper/2306.02858/) (2023)
- [AnimateDiff: Animate Your Personalized Text-to-Image Diffusion Models without Specific Tuning](https://mlsanity.com/paper/2307.04725/) (2023)
- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [MUSIQ: Multi-scale Image Quality Transformer](https://mlsanity.com/paper/2108.05997/) (2021)
- [Diffusion Models in Vision: A Survey](https://mlsanity.com/paper/2209.04747/) (2022)
- [MoCoGAN: Decomposing Motion and Content for Video Generation](https://mlsanity.com/paper/1707.04993/) (2017)
- [InternVid: A Large-scale Video-Text Dataset for Multimodal Understanding and Generation](https://mlsanity.com/paper/2307.06942/) (2023)
- [Sora: A Review on Background, Technology, Limitations, and Opportunities of Large Vision Models](https://mlsanity.com/paper/2402.17177/) (2024)
- [MagicVideo: Efficient Video Generation With Latent Diffusion Models](https://mlsanity.com/paper/2211.11018/) (2022)
- [Lumiere: A Space-Time Diffusion Model for Video Generation](https://mlsanity.com/paper/2401.12945/) (2024)
- [LAVIE: High-Quality Video Generation with Cascaded Latent Diffusion Models](https://mlsanity.com/paper/2309.15103/) (2023)
- [Preserve Your Own Correlation: A Noise Prior for Video Diffusion Models](https://mlsanity.com/paper/2305.10474/) (2023)
- [AMT: All-Pairs Multi-Field Transforms for Efficient Frame Interpolation](https://mlsanity.com/paper/2304.09790/) (2023)
- [Video Generation From Text](https://mlsanity.com/paper/1710.00421/) (2017)
- [Rendezvous: Attention Mechanisms for the Recognition of Surgical Action Triplets in Endoscopic Videos](https://mlsanity.com/paper/2109.03223/) (2021)
- [ERNIE-ViLG 2.0: Improving Text-to-Image Diffusion Model with Knowledge-Enhanced Mixture-of-Denoising-Experts](https://mlsanity.com/paper/2210.15257/) (2022)
- [Endora: Video Generation Models as Endoscopy Simulators](https://mlsanity.com/paper/2403.11050/) (2024)

## Built on by (most cited first, 15 of 15)

- [VLIPP: Towards Physically Plausible Video Generation with Vision and Language Informed Physical Prior](https://mlsanity.com/paper/2503.23368/) (2025)
- [A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers](https://mlsanity.com/paper/2508.21148/) (2025)
- [SurgSora: Object-Aware Diffusion Model for Controllable Surgical Video Generation](https://mlsanity.com/paper/2412.14018/) (2024)
- [Ophora: A Large-Scale Data-Driven Text-Guided Ophthalmic Surgical Video Generation Model](https://mlsanity.com/paper/2505.07449/) (2025)
- [MedGen: Unlocking Medical Video Generation by Scaling Granularly-annotated Medical Videos](https://mlsanity.com/paper/2507.05675/) (2025)
- [Generative Artificial Intelligence in Medical Imaging: Foundations, Progress, and Clinical Translation](https://mlsanity.com/paper/2508.09177/) (2025)
- [SG2VID: Scene Graphs Enable Fine-Grained Control for Video Synthesis](https://mlsanity.com/paper/2506.03082/) (2025)
- [From Articulated Kinematics to Routed Visual Control for Action-Conditioned Surgical Video Generation](https://mlsanity.com/paper/2605.08712/) (2026)
- [Artificial Intelligence for Biomedical Video Generation](https://mlsanity.com/paper/2411.07619/) (2024)
- [Realistic Surgical Simulation from Monocular Videos](https://mlsanity.com/paper/2412.02359/) (2024)
- [VIOLA: Towards Video In-Context Learning with Minimal Annotations](https://mlsanity.com/paper/2601.15549/) (2026)
- [ColoDiff: Integrating Dynamic Consistency With Content Awareness for Colonoscopy Video Generation](https://mlsanity.com/paper/2602.23203/) (2026)
- [Mitigating Surgical Data Imbalance with Dual-Prediction Video Diffusion Model](https://mlsanity.com/paper/2510.07345/) (2025)
- [3D4D: An Interactive, Editable, 4D World Model via 3D Video Generation](https://mlsanity.com/paper/2511.08536/) (2025)
- [REMEDY: How Far Is Video Generation from Medical Education World Models?](https://mlsanity.com/paper/2609.32460/) (2026)

## Abstract (arXiv)

Generative models hold promise for revolutionizing medical education, robot-assisted surgery, and data augmentation for medical AI development. Diffusion models can now generate realistic images from text prompts, while recent advancements have demonstrated their ability to create diverse, high-quality videos. However, these models often struggle with generating accurate representations of medical procedures and detailed anatomical structures. This paper introduces Bora, the first spatio-temporal diffusion probabilistic model designed for text-guided biomedical video generation. Bora leverages Transformer architecture and is pre-trained on general-purpose video generation tasks. It is fine-tuned through model alignment and instruction tuning using a newly established medical video corpus, which includes paired text-video data from various biomedical fields. To the best of our knowledge, this is the first attempt to establish such a comprehensive annotated biomedical video dataset. Bora is capable of generating high-quality video data across four distinct biomedical domains, adhering to medical expert standards and demonstrating consistency and diversity. This generalist video generative model holds significant potential for enhancing medical consultation and decision-making, particularly in resource-limited settings. Additionally, Bora could pave the way for immersive medical training and procedure planning. Extensive experiments on distinct medical modalities such as endoscopy, ultrasound, MRI, and cell tracking validate the effectiveness of our model in understanding biomedical instructions and its superior performance across subjects compared to state-of-the-art generation models.