# RadiomicsFill-Mammo: Synthetic Mammogram Mass Manipulation with Radiomics Features

arXiv: https://arxiv.org/abs/2407.05683 · HTML: https://mlsanity.com/paper/2407.05683/

## Key facts

- Cited by 5 papers in the map (data through 14 Oct 2026).
- Builds on 12 of its 24 references that are in the map.
- First posted on arXiv 8 Jul 2024.

## Builds on (most cited first, 12 of 12)

- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [GAN-based Synthetic Medical Image Augmentation for increased CNN Performance in Liver Lesion Classification](https://mlsanity.com/paper/1803.01229/) (2018)
- [Unsupervised Medical Image Translation with Adversarial Diffusion Models](https://mlsanity.com/paper/2207.08208/) (2022)
- [Medical Image Synthesis for Data Augmentation and Anonymization using Generative Adversarial Networks](https://mlsanity.com/paper/1807.10225/) (2018)
- [VinDr-Mammo: A large-scale benchmark dataset for computer-aided diagnosis in full-field digital mammography](https://mlsanity.com/paper/2203.11205/) (2022)
- [Adaptive Latent Diffusion Model for 3D Medical Image to Image Translation: Multi-modal Magnetic Resonance Imaging Study](https://mlsanity.com/paper/2311.00265/) (2023)
- [Improving dermatology classifiers across populations using images generated by large diffusion models](https://mlsanity.com/paper/2211.13352/) (2022)
- [Multitask Brain Tumor Inpainting with Diffusion Models: A Methodological Report](https://mlsanity.com/paper/2210.12113/) (2022)
- [Assessing robustness of radiomic features by image perturbation](https://mlsanity.com/paper/1806.06719/) (2018)
- [Synthetic Tumor Manipulation: With Radiomics Features](https://mlsanity.com/paper/2311.02586/) (2023)

## Built on by (most cited first, 5 of 5)

- [LCMem: A Universal Model for Robust Image Memorization Detection](https://mlsanity.com/paper/2512.14421/) (2025)
- [Enabling PSO-Secure Synthetic Data Sharing Using Diversity-Aware Diffusion Models](https://mlsanity.com/paper/2506.17975/) (2025)
- [Joint Holistic and Lesion Controllable Mammogram Synthesis via Gated Conditional Diffusion Model](https://mlsanity.com/paper/2507.19201/) (2025)
- [Tumor Synthesis conditioned on Radiomics](https://mlsanity.com/paper/2509.24182/) (2025)
- [Simulating Post-Neoadjuvant Chemotherapy Breast Cancer MRI via Diffusion Model with Prompt Tuning](https://mlsanity.com/paper/2509.24185/) (2025)

## Abstract (arXiv)

Motivated by the question, "Can we generate tumors with desired attributes?'' this study leverages radiomics features to explore the feasibility of generating synthetic tumor images. Characterized by its low-dimensional yet biologically meaningful markers, radiomics bridges the gap between complex medical imaging data and actionable clinical insights. We present RadiomicsFill-Mammo, the first of the RadiomicsFill series, an innovative technique that generates realistic mammogram mass images mirroring specific radiomics attributes using masked images and opposite breast images, leveraging a recent stable diffusion model. This approach also allows for the incorporation of essential clinical variables, such as BI-RADS and breast density, alongside radiomics features as conditions for mass generation. Results indicate that RadiomicsFill-Mammo effectively generates diverse and realistic tumor images based on various radiomics conditions. Results also demonstrate a significant improvement in mass detection capabilities, leveraging RadiomicsFill-Mammo as a strategy to generate simulated samples. Furthermore, RadiomicsFill-Mammo not only advances medical imaging research but also opens new avenues for enhancing treatment planning and tumor simulation. Our code is available at https://github.com/nainye/RadiomicsFill.