# Using LLMs to label medical papers according to the CIViC evidence model

arXiv: https://arxiv.org/abs/2407.04466 · HTML: https://mlsanity.com/paper/2407.04466/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 16 of its 41 references that are in the map.
- First posted on arXiv 5 Jul 2024.

## Builds on (most cited first, 16 of 16)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [RoBERTa: A Robustly Optimized BERT Pretraining Approach](https://mlsanity.com/paper/1907.11692/) (2019)
- [Longformer: The Long-Document Transformer](https://mlsanity.com/paper/2004.05150/) (2020)
- [Axiomatic Attribution for Deep Networks](https://mlsanity.com/paper/1703.01365/) (2017)
- [Don't Stop Pretraining: Adapt Language Models to Domains and Tasks](https://mlsanity.com/paper/2004.10964/) (2020)
- [Domain-Specific Language Model Pretraining for Biomedical Natural Language Processing](https://mlsanity.com/paper/2007.15779/) (2020)
- [A Survey of Transformers](https://mlsanity.com/paper/2106.04554/) (2021)
- [LinkBERT: Pretraining Language Models with Document Links](https://mlsanity.com/paper/2203.15827/) (2022)
- [Clinical-Longformer and Clinical-BigBird: Transformers for long clinical sequences](https://mlsanity.com/paper/2201.11838/) (2022)
- [Inferring Which Medical Treatments Work from Reports of Clinical Trials](https://mlsanity.com/paper/1904.01606/) (2019)
- [Evidence Inference 2.0: More Data, Better Models](https://mlsanity.com/paper/2005.04177/) (2020)
- [Are Large Language Models Ready for Healthcare? A Comparative Study on Clinical Language Understanding](https://mlsanity.com/paper/2304.05368/) (2023)
- [Utilization of Multinomial Naive Bayes Algorithm and Term Frequency Inverse Document Frequency (TF-IDF Vectorizer) in Checking the Credibility of News Tweet in the Philippines](https://mlsanity.com/paper/2306.00018/) (2023)

## Abstract (arXiv)

We introduce the sequence classification problem CIViC Evidence to the field of medical NLP. CIViC Evidence denotes the multi-label classification problem of assigning labels of clinical evidence to abstracts of scientific papers which have examined various combinations of genomic variants, cancer types, and treatment approaches. We approach CIViC Evidence using different language models: We fine-tune pretrained checkpoints of BERT and RoBERTa on the CIViC Evidence dataset and challenge their performance with models of the same architecture which have been pretrained on domain-specific text. In this context, we find that BiomedBERT and BioLinkBERT can outperform BERT on CIViC Evidence (+0.8% and +0.9% absolute improvement in class-support weighted F1 score). All transformer-based models show a clear performance edge when compared to a logistic regression trained on bigram tf-idf scores (+1.5 - 2.7% improved F1 score). We compare the aforementioned BERT-like models to OpenAI's GPT-4 in a few-shot setting (on a small subset of our original test dataset), demonstrating that, without additional prompt-engineering or fine-tuning, GPT-4 performs worse on CIViC Evidence than our six fine-tuned models (66.1% weighted F1 score compared to 71.8% for the best fine-tuned model). However, performance gets reasonably close to the benchmark of a logistic regression model trained on bigram tf-idf scores (67.7% weighted F1 score).