# MMedAgent: Learning to Use Medical Tools with Multi-modal Agent

arXiv: https://arxiv.org/abs/2407.02483 · HTML: https://mlsanity.com/paper/2407.02483/

## Key facts

- Cited by 109 papers in the map (data through 14 Oct 2026).
- Placed in Medical vision-language models, one of 16 directions in Multimodal LLMs / vision-language models.
- Builds on 34 of its 56 references that are in the map.
- First posted on arXiv 2 Jul 2024.

## Placed in

- Multimodal LLMs / vision-language models / [Medical vision-language models](https://mlsanity.com/mllm/medical-vision-language-models/)
- LLM agents and tool use / [Medical and scientific domain agents](https://mlsanity.com/agents/medical-and-scientific-domain-agents/)

## Builds on (most cited first, 30 of 34)

- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [PaLM: Scaling Language Modeling with Pathways](https://mlsanity.com/paper/2204.02311/) (2022)
- [Improved Baselines with Visual Instruction Tuning](https://mlsanity.com/paper/2310.03744/) (2023)
- [Grounding DINO: Marrying DINO with Grounded Pre-Training for Open-Set Object Detection](https://mlsanity.com/paper/2303.05499/) (2023)
- [Qwen-VL: A Versatile Vision-Language Model for Understanding, Localization, Text Reading, and Beyond](https://mlsanity.com/paper/2308.12966/) (2023)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [Flickr30k Entities: Collecting Region-to-Phrase Correspondences for Richer Image-to-Sentence Models](https://mlsanity.com/paper/1505.04870/) (2015)
- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [Yi: Open Foundation Models by 01.AI](https://mlsanity.com/paper/2403.04652/) (2024)
- [MIMIC-CXR-JPG, a large publicly available database of labeled chest radiographs](https://mlsanity.com/paper/1901.07042/) (2019)
- [BiomedCLIP: a multimodal biomedical foundation model pretrained from fifteen million scientific image-text pairs](https://mlsanity.com/paper/2303.00915/) (2023)
- [PathVQA: 30000+ Questions for Medical Visual Question Answering](https://mlsanity.com/paper/2003.10286/) (2020)
- [SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answering](https://mlsanity.com/paper/2102.09542/) (2021)
- [Med-Flamingo: a Multimodal Medical Few-shot Learner](https://mlsanity.com/paper/2307.15189/) (2023)
- [A Real-World WebAgent with Planning, Long Context Understanding, and Program Synthesis](https://mlsanity.com/paper/2307.12856/) (2023)
- [MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoning](https://mlsanity.com/paper/2311.10537/) (2023)
- [Mobile-Agent: Autonomous Multi-Modal Mobile Device Agent with Visual Perception](https://mlsanity.com/paper/2401.16158/) (2024)
- [Segment Anything Model for Medical Image Analysis: an Experimental Study](https://mlsanity.com/paper/2304.10517/) (2023)
- [VinDr-CXR: An open dataset of chest X-rays with radiologist's annotations](https://mlsanity.com/paper/2012.15029/) (2020)
- [AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environments](https://mlsanity.com/paper/2405.07960/) (2024)
- [Agent Hospital: A Simulacrum of Hospital with Evolvable Medical Agents](https://mlsanity.com/paper/2405.02957/) (2024)
- [LLaVA-Plus: Learning to Use Tools for Creating Multimodal Agents](https://mlsanity.com/paper/2311.05437/) (2023)
- [You Only Look at Screens: Multimodal Chain-of-Action Agents](https://mlsanity.com/paper/2309.11436/) (2023)
- [JARVIS-1: Open-World Multi-task Agents with Memory-Augmented Multimodal Language Models](https://mlsanity.com/paper/2311.05997/) (2023)
- [BiomedParse: a biomedical foundation model for image parsing of everything everywhere all at once](https://mlsanity.com/paper/2405.12971/) (2024)
- [CT2Rep: Automated Radiology Report Generation for 3D Medical Imaging](https://mlsanity.com/paper/2403.06801/) (2024)
- [MP5: A Multi-modal Open-ended Embodied System in Minecraft via Active Perception](https://mlsanity.com/paper/2312.07472/) (2023)
- [ChatVideo: A Tracklet-centric Multimodal and Versatile Video Understanding System](https://mlsanity.com/paper/2304.14407/) (2023)
- [PathAsst: A Generative Foundation AI Assistant Towards Artificial General Intelligence of Pathology](https://mlsanity.com/paper/2305.15072/) (2023)

## Built on by (most cited first, 30 of 109)

- [A Survey of LLM-based Agents in Medicine: How far are we from Baymax?](https://mlsanity.com/paper/2502.11211/) (2025)
- [MedAgent-Pro: Towards Evidence-based Multi-modal Medical Diagnosis via Reasoning Agentic Workflow](https://mlsanity.com/paper/2503.18968/) (2025)
- [MedRAX: Medical Reasoning Agent for Chest X-ray](https://mlsanity.com/paper/2502.02673/) (2025)
- [OctoTools: An Agentic Framework with Extensible Tools for Complex Reasoning](https://mlsanity.com/paper/2502.11271/) (2025)
- [MedAgentBench: A Realistic Virtual EHR Environment to Benchmark Medical LLM Agents](https://mlsanity.com/paper/2501.14654/) (2025)
- [VILA-M3: Enhancing Vision-Language Models with Medical Expert Knowledge](https://mlsanity.com/paper/2411.12915/) (2024)
- [A Survey of Agentic Reasoning for Large Language Models: Towards Recursively Self-Improving and Collective Agents](https://mlsanity.com/paper/2601.12538/) (2026)
- [A Survey on the Optimization of Large Language Model-based Agents](https://mlsanity.com/paper/2503.12434/) (2025)
- [DrugAgent: Automating AI-aided Drug Discovery Programming through LLM Multi-Agent Collaboration](https://mlsanity.com/paper/2411.15692/) (2024)
- [MMedAgent-RL: Optimizing Multi-Agent Collaboration for Multimodal Medical Reasoning](https://mlsanity.com/paper/2506.00555/) (2025)
- [Privacy in Action: Towards Realistic Privacy Mitigation and Evaluation for LLM-Powered Agents](https://mlsanity.com/paper/2509.17488/) (2025)
- [MEDCO: Medical Education Copilots Based on A Multi-Agent Framework](https://mlsanity.com/paper/2408.12496/) (2024)
- [MedSAM3: Delving into Segment Anything with Medical Concepts](https://mlsanity.com/paper/2511.19046/) (2025)
- [Beyond the Final Answer: Evaluating the Reasoning Trajectories of Tool-Augmented Agents](https://mlsanity.com/paper/2510.02837/) (2025)
- [MedAgentGym: A Scalable Agentic Training Environment for Code-Centric Reasoning in Biomedical Data Science](https://mlsanity.com/paper/2506.04405/) (2025)
- [ReflecTool: Towards Reflection-Aware Tool-Augmented Clinical Agents](https://mlsanity.com/paper/2410.17657/) (2024)
- [ToolTree: Efficient LLM Agent Tool Planning via Dual-Feedback Monte Carlo Tree Search and Bidirectional Pruning](https://mlsanity.com/paper/2603.12740/) (2026)
- [A co-evolving agentic AI system for medical imaging analysis](https://mlsanity.com/paper/2509.20279/) (2025)
- [SurgRAW: Multi-Agent Workflow with Chain of Thought Reasoning for Robotic Surgical Video Analysis](https://mlsanity.com/paper/2503.10265/) (2025)
- [Think Twice to See More: Iterative Visual Reasoning in Medical VLMs](https://mlsanity.com/paper/2510.10052/) (2025)
- [MedSynapse-V: Bridging Visual Perception and Clinical Intuition via Latent Memory Evolution](https://mlsanity.com/paper/2604.26283/) (2026)
- [BannerAgency: Advertising Banner Design with Multimodal LLM Agents](https://mlsanity.com/paper/2503.11060/) (2025)
- [Evolving Medical Imaging Agents via Experience-driven Self-skill Discovery](https://mlsanity.com/paper/2603.05860/) (2026)
- [End-to-End Agentic RAG System Training for Traceable Diagnostic Reasoning](https://mlsanity.com/paper/2508.15746/) (2025)
- [Ophiuchus: Incentivizing Tool-augmented "Think with Images" for Joint Medical Segmentation, Understanding and Reasoning](https://mlsanity.com/paper/2512.14157/) (2025)
- [IBISAgent: Reinforcing Pixel-Level Visual Reasoning in MLLMs for Universal Biomedical Object Referring and Segmentation](https://mlsanity.com/paper/2601.03054/) (2026)
- [A Call for Collaborative Intelligence: Why Human-Agent Systems Should Precede AI Autonomy](https://mlsanity.com/paper/2506.09420/) (2025)
- [ADAgent: LLM Agent for Alzheimer's Disease Analysis with Collaborative Coordinator](https://mlsanity.com/paper/2506.11150/) (2025)
- [MedLA: A Logic-Driven Multi-Agent Framework for Complex Medical Reasoning with Large Language Models](https://mlsanity.com/paper/2509.23725/) (2025)
- [Emerging Cyber Attack Risks of Medical AI Agents](https://mlsanity.com/paper/2504.03759/) (2025)

## Abstract (arXiv)

Multi-Modal Large Language Models (MLLMs), despite being successful, exhibit limited generality and often fall short when compared to specialized models. Recently, LLM-based agents have been developed to address these challenges by selecting appropriate specialized models as tools based on user inputs. However, such advancements have not been extensively explored within the medical domain. To bridge this gap, this paper introduces the first agent explicitly designed for the medical field, named Multi-modal Medical Agent (MMedAgent). We curate an instruction-tuning dataset comprising six medical tools solving seven tasks across five modalities, enabling the agent to choose the most suitable tools for a given task. Comprehensive experiments demonstrate that MMedAgent achieves superior performance across a variety of medical tasks compared to state-of-the-art open-source methods and even the closed-source model, GPT-4o. Furthermore, MMedAgent exhibits efficiency in updating and integrating new medical tools. Codes and models are all available.