# Automated Immunophenotyping Assessment for Diagnosing Childhood Acute Leukemia using Set-Transformers

arXiv: https://arxiv.org/abs/2406.18309 · HTML: https://mlsanity.com/paper/2406.18309/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 5 of its 23 references that are in the map.
- First posted on arXiv 26 Jun 2024.

## Builds on (most cited first, 5 of 5)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Layer Normalization](https://mlsanity.com/paper/1607.06450/) (2016)
- [Automated Identification of Cell Populations in Flow Cytometry Data with Transformers](https://mlsanity.com/paper/2108.10072/) (2021)
- [FATE: Feature-Agnostic Transformer-based Encoder for learning generalized embedding spaces in flow cytometry data](https://mlsanity.com/paper/2311.03314/) (2023)

## Abstract (arXiv)

Acute Leukemia is the most common hematologic malignancy in children and adolescents. A key methodology in the diagnostic evaluation of this malignancy is immunophenotyping based on Multiparameter Flow Cytometry (FCM). However, this approach is manual, and thus time-consuming and subjective. To alleviate this situation, we propose in this paper the FCM-Former, a machine learning, self-attention based FCM-diagnostic tool, automating the immunophenotyping assessment in Childhood Acute Leukemia. The FCM-Former is trained in a supervised manner, by directly using flow cytometric data. Our FCM-Former achieves an accuracy of 96.5% assigning lineage to each sample among 960 cases of either acute B-cell, T-cell lymphoblastic, and acute myeloid leukemia (B-ALL, T-ALL, AML). To the best of our knowledge, the FCM-Former is the first work that automates the immunophenotyping assessment with FCM data in diagnosing pediatric Acute Leukemia.