# Advancing Cell Detection in Anterior Segment Optical Coherence Tomography Images

arXiv: https://arxiv.org/abs/2406.17577 · HTML: https://mlsanity.com/paper/2406.17577/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 12 of its 48 references that are in the map.
- First posted on arXiv 25 Jun 2024.

## Builds on (most cited first, 12 of 12)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks](https://mlsanity.com/paper/1506.01497/) (2015)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [End-to-End Object Detection with Transformers](https://mlsanity.com/paper/2005.12872/) (2020)
- [Mask R-CNN](https://mlsanity.com/paper/1703.06870/) (2017)
- [Encoder-Decoder with Atrous Separable Convolution for Semantic Image Segmentation](https://mlsanity.com/paper/1802.02611/) (2018)
- [Pyramid Scene Parsing Network](https://mlsanity.com/paper/1612.01105/) (2016)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [Cascade R-CNN: Delving into High Quality Object Detection](https://mlsanity.com/paper/1712.00726/) (2017)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [EfficientDet: Scalable and Efficient Object Detection](https://mlsanity.com/paper/1911.09070/) (2019)
- [Customized Segment Anything Model for Medical Image Segmentation](https://mlsanity.com/paper/2304.13785/) (2023)

## Abstract (arXiv)

Anterior uveitis, a common form of eye inflammation, can lead to permanent vision loss if not promptly diagnosed. Monitoring this condition involves quantifying inflammatory cells in the anterior chamber (AC) of the eye, which can be captured using Anterior Segment Optical Coherence Tomography (AS-OCT). However, manually identifying cells in AS-OCT images is time-consuming and subjective. Moreover, existing automated approaches may have limitations in both the effectiveness of detecting cells and the reliability of their detection results. To address these challenges, we propose an automated framework to detect cells in the AS-OCT images. This framework consists of a zero-shot chamber segmentation module and a cell detection module. The first module segments the AC area in the image without requiring human-annotated training data. Subsequently, the second module identifies individual cells within the segmented AC region. Through experiments, our framework demonstrates superior performance compared to current state-of-the-art methods for both AC segmentation and cell detection tasks. Notably, we find that previous cell detection approaches could suffer from low recall, potentially overlooking a significant number of cells. In contrast, our framework offers an improved solution, which could benefit the diagnosis and study of anterior uveitis. Our code for cell detection is publicly available at: https://github.com/joeybyc/cell_detection.