# CriDiff: Criss-cross Injection Diffusion Framework via Generative Pre-train for Prostate Segmentation

arXiv: https://arxiv.org/abs/2406.14186 · HTML: https://mlsanity.com/paper/2406.14186/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 16 of its 28 references that are in the map.
- First posted on arXiv 20 Jun 2024.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 16 of 16)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [PVT v2: Improved Baselines with Pyramid Vision Transformer](https://mlsanity.com/paper/2106.13797/) (2021)
- [UNet++: Redesigning Skip Connections to Exploit Multiscale Features in Image Segmentation](https://mlsanity.com/paper/1912.05074/) (2019)
- [SegDiff: Image Segmentation with Diffusion Probabilistic Models](https://mlsanity.com/paper/2112.00390/) (2021)
- [Diffusion Models for Implicit Image Segmentation Ensembles](https://mlsanity.com/paper/2112.03145/) (2021)
- [UCTransNet: Rethinking the Skip Connections in U-Net from a Channel-wise Perspective with Transformer](https://mlsanity.com/paper/2109.04335/) (2021)
- [MedSegDiff: Medical Image Segmentation with Diffusion Probabilistic Model](https://mlsanity.com/paper/2211.00611/) (2022)
- [MedSegDiff-V2: Diffusion based Medical Image Segmentation with Transformer](https://mlsanity.com/paper/2301.11798/) (2023)
- [MicroSegNet: A Deep Learning Approach for Prostate Segmentation on Micro-Ultrasound Images](https://mlsanity.com/paper/2305.19956/) (2023)
- [G-CASCADE: Efficient Cascaded Graph Convolutional Decoding for 2D Medical Image Segmentation](https://mlsanity.com/paper/2310.16175/) (2023)
- [CAT-Net: A Cross-Slice Attention Transformer Model for Prostate Zonal Segmentation in MRI](https://mlsanity.com/paper/2203.15163/) (2022)
- [Deep Learning for fully automatic detection, segmentation, and Gleason Grade estimation of prostate cancer in multiparametric Magnetic Resonance Images](https://mlsanity.com/paper/2103.12650/) (2021)
- [DermoSegDiff: A Boundary-aware Segmentation Diffusion Model for Skin Lesion Delineation](https://mlsanity.com/paper/2308.02959/) (2023)

## Abstract (arXiv)

Recently, the Diffusion Probabilistic Model (DPM)-based methods have achieved substantial success in the field of medical image segmentation. However, most of these methods fail to enable the diffusion model to learn edge features and non-edge features effectively and to inject them efficiently into the diffusion backbone. Additionally, the domain gap between the images features and the diffusion model features poses a great challenge to prostate segmentation. In this paper, we proposed CriDiff, a two-stage feature injecting framework with a Crisscross Injection Strategy (CIS) and a Generative Pre-train (GP) approach for prostate segmentation. The CIS maximizes the use of multi-level features by efficiently harnessing the complementarity of high and low-level features. To effectively learn multi-level of edge features and non-edge features, we proposed two parallel conditioners in the CIS: the Boundary Enhance Conditioner (BEC) and the Core Enhance Conditioner (CEC), which discriminatively model the image edge regions and non-edge regions, respectively. Moreover, the GP approach eases the inconsistency between the images features and the diffusion model without adding additional parameters. Extensive experiments on four benchmark datasets demonstrate the effectiveness of the proposed method and achieve state-of-the-art performance on four evaluation metrics.