# Evaluating the Impact of Sequence Combinations on Breast Tumor Segmentation in Multiparametric MRI

arXiv: https://arxiv.org/abs/2406.07813 · HTML: https://mlsanity.com/paper/2406.07813/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 4 of its 18 references that are in the map.
- First posted on arXiv 12 Jun 2024.

## Builds on (most cited first, 4 of 4)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [Convolutional LSTM Network: A Machine Learning Approach for Precipitation Nowcasting](https://mlsanity.com/paper/1506.04214/) (2015)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)

## Abstract (arXiv)

Multiparametric magnetic resonance imaging (mpMRI) is a key tool for assessing breast cancer progression. Although deep learning has been applied to automate tumor segmentation in breast MRI, the effect of sequence combinations in mpMRI remains under-investigated. This study explores the impact of different combinations of T2-weighted (T2w), dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) map on breast tumor segmentation using nnU-Net. Evaluated on a multicenter mpMRI dataset, the nnU-Net model using DCE sequences achieved a Dice similarity coefficient (DSC) of 0.69 ± 0.18 for functional tumor volume (FTV) segmentation. For whole tumor mask (WTM) segmentation, adding the predicted FTV to DWI and ADC map improved the DSC from 0.57 ± 0.24 to 0.60 ± 0.21. Adding T2w did not yield significant improvement, which still requires further investigation under a more standardized imaging protocol. This study serves as a foundation for future work on predicting breast cancer treatment response using mpMRI.