# MS-Diffusion: Multi-subject Zero-shot Image Personalization with Layout Guidance

arXiv: https://arxiv.org/abs/2406.07209 · HTML: https://mlsanity.com/paper/2406.07209/

## Key facts

- Cited by 144 papers in the map (data through 14 Oct 2026).
- Builds on 51 of its 57 references that are in the map.
- First posted on arXiv 11 Jun 2024.

## Builds on (most cited first, 30 of 51)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding](https://mlsanity.com/paper/2205.11487/) (2022)
- [BLIP-2: Bootstrapping Language-Image Pre-training with Frozen Image Encoders and Large Language Models](https://mlsanity.com/paper/2301.12597/) (2023)
- [Scalable Diffusion Models with Transformers](https://mlsanity.com/paper/2212.09748/) (2022)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [Neural Discrete Representation Learning](https://mlsanity.com/paper/1711.00937/) (2017)
- [Flamingo: a Visual Language Model for Few-Shot Learning](https://mlsanity.com/paper/2204.14198/) (2022)
- [SDXL: Improving Latent Diffusion Models for High-Resolution Image Synthesis](https://mlsanity.com/paper/2307.01952/) (2023)
- [Scaling Rectified Flow Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2403.03206/) (2024)
- [Grounding DINO: Marrying DINO with Grounded Pre-Training for Open-Set Object Detection](https://mlsanity.com/paper/2303.05499/) (2023)
- [DreamBooth: Fine Tuning Text-to-Image Diffusion Models for Subject-Driven Generation](https://mlsanity.com/paper/2208.12242/) (2022)
- [Scaling Instruction-Finetuned Language Models](https://mlsanity.com/paper/2210.11416/) (2022)
- [InstructPix2Pix: Learning to Follow Image Editing Instructions](https://mlsanity.com/paper/2211.09800/) (2022)
- [Prompt-to-Prompt Image Editing with Cross Attention Control](https://mlsanity.com/paper/2208.01626/) (2022)
- [An Image is Worth One Word: Personalizing Text-to-Image Generation using Textual Inversion](https://mlsanity.com/paper/2208.01618/) (2022)
- [IP-Adapter: Text Compatible Image Prompt Adapter for Text-to-Image Diffusion Models](https://mlsanity.com/paper/2308.06721/) (2023)
- [Imagic: Text-Based Real Image Editing with Diffusion Models](https://mlsanity.com/paper/2210.09276/) (2022)
- [Multi-Concept Customization of Text-to-Image Diffusion](https://mlsanity.com/paper/2212.04488/) (2022)
- [PixArt-α: Fast Training of Diffusion Transformer for Photorealistic Text-to-Image Synthesis](https://mlsanity.com/paper/2310.00426/) (2023)
- [GLIGEN: Open-Set Grounded Text-to-Image Generation](https://mlsanity.com/paper/2301.07093/) (2023)
- [All are Worth Words: A ViT Backbone for Diffusion Models](https://mlsanity.com/paper/2209.12152/) (2022)
- [Generative Multimodal Models are In-Context Learners](https://mlsanity.com/paper/2312.13286/) (2023)
- [BLIP-Diffusion: Pre-trained Subject Representation for Controllable Text-to-Image Generation and Editing](https://mlsanity.com/paper/2305.14720/) (2023)
- [InstantID: Zero-shot Identity-Preserving Generation in Seconds](https://mlsanity.com/paper/2401.07519/) (2024)
- [ELITE: Encoding Visual Concepts into Textual Embeddings for Customized Text-to-Image Generation](https://mlsanity.com/paper/2302.13848/) (2023)
- [AnyDoor: Zero-shot Object-level Image Customization](https://mlsanity.com/paper/2307.09481/) (2023)

## Built on by (most cited first, 30 of 144)

- [OmniGen: Unified Image Generation](https://mlsanity.com/paper/2409.11340/) (2024)
- [Less-to-More Generalization: Unlocking More Controllability by In-Context Generation](https://mlsanity.com/paper/2504.02160/) (2025)
- [EasyControl: Adding Efficient and Flexible Control for Diffusion Transformer](https://mlsanity.com/paper/2503.07027/) (2025)
- [CatVTON: Concatenation Is All You Need for Virtual Try-On with Diffusion Models](https://mlsanity.com/paper/2407.15886/) (2024)
- [Unified Multimodal Understanding and Generation Models: Advances, Challenges, and Opportunities](https://mlsanity.com/paper/2505.02567/) (2025)
- [DreamO: A Unified Framework for Image Customization](https://mlsanity.com/paper/2504.16915/) (2025)
- [ConceptMaster: Multi-Concept Video Customization on Diffusion Transformer Models Without Test-Time Tuning](https://mlsanity.com/paper/2501.04698/) (2025)
- [XVerse: Consistent Multi-Subject Control of Identity and Semantic Attributes via DiT Modulation](https://mlsanity.com/paper/2506.21416/) (2025)
- [Large-Scale Text-to-Image Model with Inpainting is a Zero-Shot Subject-Driven Image Generator](https://mlsanity.com/paper/2411.15466/) (2024)
- [Region-Aware Text-to-Image Generation via Hard Binding and Soft Refinement](https://mlsanity.com/paper/2411.06558/) (2024)
- [ART: Anonymous Region Transformer for Variable Multi-Layer Transparent Image Generation](https://mlsanity.com/paper/2502.18364/) (2025)
- [CreatiDesign: A Unified Multi-Conditional Diffusion Transformer for Creative Graphic Design](https://mlsanity.com/paper/2505.19114/) (2025)
- [Training-free Regional Prompting for Diffusion Transformers](https://mlsanity.com/paper/2411.02395/) (2024)
- [Personalize Anything for Free with Diffusion Transformer](https://mlsanity.com/paper/2503.12590/) (2025)
- [MAGREF: Masked Guidance for Any-Reference Video Generation with Subject Disentanglement](https://mlsanity.com/paper/2505.23742/) (2025)
- [Personalized Image Generation with Deep Generative Models: A Decade Survey](https://mlsanity.com/paper/2502.13081/) (2025)
- [Personalized Multimodal Large Language Models: A Survey](https://mlsanity.com/paper/2412.02142/) (2024)
- [CINEMA: Coherent Multi-Subject Video Generation via MLLM-Based Guidance](https://mlsanity.com/paper/2503.10391/) (2025)
- [UMO: Scaling Multi-Identity Consistency for Image Customization via Matching Reward](https://mlsanity.com/paper/2509.06818/) (2025)
- [PatchDPO: Patch-level DPO for Finetuning-free Personalized Image Generation](https://mlsanity.com/paper/2412.03177/) (2024)
- [DiffSensei: Bridging Multi-Modal LLMs and Diffusion Models for Customized Manga Generation](https://mlsanity.com/paper/2412.07589/) (2024)
- [OmniCache: A Trajectory-Oriented Global Perspective on Training-Free Cache Reuse for Diffusion Transformer Models](https://mlsanity.com/paper/2508.16212/) (2025)
- [ContextGen: Contextual Layout Anchoring for Identity-Consistent Multi-Instance Generation](https://mlsanity.com/paper/2510.11000/) (2025)
- [MMIG-Bench: Towards Comprehensive and Explainable Evaluation of Multi-Modal Image Generation Models](https://mlsanity.com/paper/2505.19415/) (2025)
- [RealCustom++: Representing Images as Real Textual Word for Real-Time Customization](https://mlsanity.com/paper/2408.09744/) (2024)
- [RealGeneral: Unifying Visual Generation via Temporal In-Context Learning with Video Models](https://mlsanity.com/paper/2503.10406/) (2025)
- [Query-Kontext: An Unified Multimodal Model for Image Generation and Editing](https://mlsanity.com/paper/2509.26641/) (2025)
- [T2I-FactualBench: Benchmarking the Factuality of Text-to-Image Models with Knowledge-Intensive Concepts](https://mlsanity.com/paper/2412.04300/) (2024)
- [MOSAIC: Multi-Subject Personalized Generation via Correspondence-Aware Alignment and Disentanglement](https://mlsanity.com/paper/2509.01977/) (2025)
- [ActWorld: From Explorable to Interactive World Model via Action-Aware Memory](https://mlsanity.com/paper/2606.17730/) (2026)

## Abstract (arXiv)

Recent advancements in text-to-image generation models have dramatically enhanced the generation of photorealistic images from textual prompts, leading to an increased interest in personalized text-to-image applications, particularly in multi-subject scenarios. However, these advances are hindered by two main challenges: firstly, the need to accurately maintain the details of each referenced subject in accordance with the textual descriptions; and secondly, the difficulty in achieving a cohesive representation of multiple subjects in a single image without introducing inconsistencies. To address these concerns, our research introduces the MS-Diffusion framework for layout-guided zero-shot image personalization with multi-subjects. This innovative approach integrates grounding tokens with the feature resampler to maintain detail fidelity among subjects. With the layout guidance, MS-Diffusion further improves the cross-attention to adapt to the multi-subject inputs, ensuring that each subject condition acts on specific areas. The proposed multi-subject cross-attention orchestrates harmonious inter-subject compositions while preserving the control of texts. Comprehensive quantitative and qualitative experiments affirm that this method surpasses existing models in both image and text fidelity, promoting the development of personalized text-to-image generation. The project page is https://MS-Diffusion.github.io.