# Performance of large language models in numerical vs. semantic medical knowledge: Benchmarking on evidence-based Q&As

arXiv: https://arxiv.org/abs/2406.03855 · HTML: https://mlsanity.com/paper/2406.03855/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 10 of its 38 references that are in the map.
- First posted on arXiv 6 Jun 2024.

## Builds on (most cited first, 10 of 10)

- [Language Models (Mostly) Know What They Know](https://mlsanity.com/paper/2207.05221/) (2022)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answering](https://mlsanity.com/paper/2203.14371/) (2022)
- [Towards Expert-Level Medical Question Answering with Large Language Models](https://mlsanity.com/paper/2305.09617/) (2023)
- [Head-to-Tail: How Knowledgeable are Large Language Models (LLMs)? A.K.A. Will LLMs Replace Knowledge Graphs?](https://mlsanity.com/paper/2308.10168/) (2023)
- [Benchmarking Large Language Models on CMExam -- A Comprehensive Chinese Medical Exam Dataset](https://mlsanity.com/paper/2306.03030/) (2023)
- [Knowledge Graphs as Context Sources for LLM-Based Explanations of Learning Recommendations](https://mlsanity.com/paper/2403.03008/) (2024)
- [Evaluating LLMs on Document-Based QA: Exact Answer Selection and Numerical Extraction using Cogtale dataset](https://mlsanity.com/paper/2311.07878/) (2023)

## Built on by (most cited first, 2 of 2)

- [JMedBench: A Benchmark for Evaluating Japanese Biomedical Large Language Models](https://mlsanity.com/paper/2409.13317/) (2024)
- [SOLID: a Framework of Synergizing Optimization and LLMs for Intelligent Decision-Making](https://mlsanity.com/paper/2511.15202/) (2025)

## Abstract (arXiv)

Clinical problem-solving requires processing of semantic medical knowledge such as illness scripts and numerical medical knowledge of diagnostic tests for evidence-based decision-making. As large language models (LLMs) show promising results in many aspects of language-based clinical practice, their ability to generate non-language evidence-based answers to clinical questions is inherently limited by tokenization. Therefore, we evaluated LLMs' performance on two question types: numeric (correlating findings) and semantic (differentiating entities) while examining differences within and between LLMs in medical aspects and comparing their performance to humans. To generate straightforward multi-choice questions and answers (QAs) based on evidence-based medicine (EBM), we used a comprehensive medical knowledge graph (encompassed data from more than 50,00 peer-reviewed articles) and created the "EBMQA". EBMQA contains 105,000 QAs labeled with medical and non-medical topics and classified into numerical or semantic questions. We benchmarked this dataset using more than 24,500 QAs on two state-of-the-art LLMs: Chat-GPT4 and Claude3-Opus. We evaluated the LLMs accuracy on semantic and numerical question types and according to sub-labeled topics. For validation, six medical experts were tested on 100 numerical EBMQA questions. We found that both LLMs excelled more in semantic than numerical QAs, with Claude3 surpassing GPT4 in numerical QAs. However, both LLMs showed inter and intra gaps in different medical aspects and remained inferior to humans. Thus, their medical advice should be addressed carefully.