# Length-scale study in deep learning prediction for non-small cell lung cancer brain metastasis

arXiv: https://arxiv.org/abs/2406.00555 · HTML: https://mlsanity.com/paper/2406.00555/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 22 of its 59 references that are in the map.
- First posted on arXiv 1 Jun 2024.

## Builds on (most cited first, 22 of 22)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Explaining and Harnessing Adversarial Examples](https://mlsanity.com/paper/1412.6572/) (2014)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- [Axiomatic Attribution for Deep Networks](https://mlsanity.com/paper/1703.01365/) (2017)
- [Deep Inside Convolutional Networks: Visualising Image Classification Models and Saliency Maps](https://mlsanity.com/paper/1312.6034/) (2013)
- [Visualizing and Understanding Convolutional Networks](https://mlsanity.com/paper/1311.2901/) (2013)
- [Concept Bottleneck Models](https://mlsanity.com/paper/2007.04612/) (2020)
- [Striving for Simplicity: The All Convolutional Net](https://mlsanity.com/paper/1412.6806/) (2014)
- [This Looks Like That: Deep Learning for Interpretable Image Recognition](https://mlsanity.com/paper/1806.10574/) (2018)
- [Understanding Neural Networks Through Deep Visualization](https://mlsanity.com/paper/1506.06579/) (2015)
- [Deep Learning for Case-Based Reasoning through Prototypes: A Neural Network that Explains Its Predictions](https://mlsanity.com/paper/1710.04806/) (2017)
- [Cost Sensitive Learning of Deep Feature Representations from Imbalanced Data](https://mlsanity.com/paper/1508.03422/) (2015)
- [Interpretable Convolutional Neural Networks](https://mlsanity.com/paper/1710.00935/) (2017)
- [Explainable artificial intelligence (XAI) in deep learning-based medical image analysis](https://mlsanity.com/paper/2107.10912/) (2021)
- [Explainable deep learning models in medical image analysis](https://mlsanity.com/paper/2005.13799/) (2020)
- [Interpreting Deep Visual Representations via Network Dissection](https://mlsanity.com/paper/1711.05611/) (2017)
- [Transparency of Deep Neural Networks for Medical Image Analysis: A Review of Interpretability Methods](https://mlsanity.com/paper/2111.02398/) (2021)
- [Deep Learning for Survival Analysis: A Review](https://mlsanity.com/paper/2305.14961/) (2023)
- [Explaining a Series of Models by Propagating Shapley Values](https://mlsanity.com/paper/2105.00108/) (2021)
- [An Interpretable Deep Hierarchical Semantic Convolutional Neural Network for Lung Nodule Malignancy Classification](https://mlsanity.com/paper/1806.00712/) (2018)
- [A Novel Explainable Artificial Intelligence Model in Image Classification problem](https://mlsanity.com/paper/2307.04137/) (2023)

## Abstract (arXiv)

Deep learning assisted digital pathology has the potential to impact clinical practice in significant ways. In recent studies, deep neural network (DNN) enabled analysis outperforms human pathologists. Increasing sizes and complexity of the DNN architecture generally improves performance at the cost of DNN's explainability. For pathology, this lack of DNN explainability is particularly problematic as it hinders the broader clinical interpretation of the pathology features that may provide physiological disease insights. To better assess the features that DNN uses in developing predictive algorithms to interpret digital microscopic images, we sought to understand the role of resolution and tissue scale and here describe a novel method for studying the predictive feature length-scale that underpins a DNN's predictive power. We applied the method to study a DNN's predictive capability in the case example of brain metastasis prediction from early-stage non-small-cell lung cancer biopsy slides. The study highlights the DNN attention in the brain metastasis prediction targeting both cellular scale (resolution) and tissue scale features on H&E-stained histological whole slide images. At the cellular scale, we see that DNN's predictive power is progressively increased at higher resolution (i.e., lower resolvable feature length) and is largely lost when the resolvable feature length is longer than 5 microns. In addition, DNN uses more macro-scale features (maximal feature length) associated with tissue organization/architecture and is optimized when assessing visual fields larger than 41 microns. This study for the first time demonstrates the length-scale requirements necessary for optimal DNN learning on digital whole slide images.