# PediatricsGPT: Large Language Models as Chinese Medical Assistants for Pediatric Applications

arXiv: https://arxiv.org/abs/2405.19266 · HTML: https://mlsanity.com/paper/2405.19266/

## Key facts

- Cited by 16 papers in the map (data through 14 Oct 2026).
- Builds on 39 of its 58 references that are in the map.
- First posted on arXiv 29 May 2024.

## Builds on (most cited first, 30 of 39)

- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Proximal Policy Optimization Algorithms](https://mlsanity.com/paper/1707.06347/) (2017)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Llama 2: Open Foundation and Fine-Tuned Chat Models](https://mlsanity.com/paper/2307.09288/) (2023)
- [Direct Preference Optimization: Your Language Model is Secretly a Reward Model](https://mlsanity.com/paper/2305.18290/) (2023)
- [Finetuned Language Models Are Zero-Shot Learners](https://mlsanity.com/paper/2109.01652/) (2021)
- [Training a Helpful and Harmless Assistant with Reinforcement Learning from Human Feedback](https://mlsanity.com/paper/2204.05862/) (2022)
- [Qwen Technical Report](https://mlsanity.com/paper/2309.16609/) (2023)
- [Mistral 7B](https://mlsanity.com/paper/2310.06825/) (2023)
- [Self-Instruct: Aligning Language Models with Self-Generated Instructions](https://mlsanity.com/paper/2212.10560/) (2022)
- [ZeRO: Memory Optimizations Toward Training Trillion Parameter Models](https://mlsanity.com/paper/1910.02054/) (2019)
- [GLM: General Language Model Pretraining with Autoregressive Blank Infilling](https://mlsanity.com/paper/2103.10360/) (2021)
- [GLM-130B: An Open Bilingual Pre-trained Model](https://mlsanity.com/paper/2210.02414/) (2022)
- [Instruction Tuning with GPT-4](https://mlsanity.com/paper/2304.03277/) (2023)
- [Baichuan 2: Open Large-scale Language Models](https://mlsanity.com/paper/2309.10305/) (2023)
- [Textbooks Are All You Need](https://mlsanity.com/paper/2306.11644/) (2023)
- [The Curse of Recursion: Training on Generated Data Makes Models Forget](https://mlsanity.com/paper/2305.17493/) (2023)
- [ChatDoctor: A Medical Chat Model Fine-Tuned on a Large Language Model Meta-AI (LLaMA) Using Medical Domain Knowledge](https://mlsanity.com/paper/2303.14070/) (2023)
- [Efficient and Effective Text Encoding for Chinese LLaMA and Alpaca](https://mlsanity.com/paper/2304.08177/) (2023)
- [MEDITRON-70B: Scaling Medical Pretraining for Large Language Models](https://mlsanity.com/paper/2311.16079/) (2023)
- [Is Reinforcement Learning (Not) for Natural Language Processing: Benchmarks, Baselines, and Building Blocks for Natural Language Policy Optimization](https://mlsanity.com/paper/2210.01241/) (2022)
- [Secrets of RLHF in Large Language Models Part I: PPO](https://mlsanity.com/paper/2307.04964/) (2023)
- [HuatuoGPT, towards Taming Language Model to Be a Doctor](https://mlsanity.com/paper/2305.15075/) (2023)
- [HuaTuo: Tuning LLaMA Model with Chinese Medical Knowledge](https://mlsanity.com/paper/2304.06975/) (2023)
- [DoctorGLM: Fine-tuning your Chinese Doctor is not a Herculean Task](https://mlsanity.com/paper/2304.01097/) (2023)
- [Zhongjing: Enhancing the Chinese Medical Capabilities of Large Language Model through Expert Feedback and Real-world Multi-turn Dialogue](https://mlsanity.com/paper/2308.03549/) (2023)
- [HuatuoGPT-II, One-stage Training for Medical Adaption of LLMs](https://mlsanity.com/paper/2311.09774/) (2023)
- [DISC-MedLLM: Bridging General Large Language Models and Real-World Medical Consultation](https://mlsanity.com/paper/2308.14346/) (2023)

## Built on by (most cited first, 16 of 16)

- [Reinforcement Learning Meets Large Language Models: A Survey of Advancements and Applications Across the LLM Lifecycle](https://mlsanity.com/paper/2509.16679/) (2025)
- [Improving Factuality in Large Language Models via Decoding-Time Hallucinatory and Truthful Comparators](https://mlsanity.com/paper/2408.12325/) (2024)
- [Resolving Evidence Sparsity: Agentic Context Engineering for Long-Document Understanding](https://mlsanity.com/paper/2511.22850/) (2025)
- [A Survey on Large Language Models from General Purpose to Medical Applications: Datasets, Methodologies, and Evaluations](https://mlsanity.com/paper/2406.10303/) (2024)
- [MedAide: Information Fusion and Anatomy of Medical Intents via LLM-based Agent Collaboration](https://mlsanity.com/paper/2410.12532/) (2024)
- [Multimodal Large Language Models for Medicine: A Comprehensive Survey](https://mlsanity.com/paper/2504.21051/) (2025)
- [OralGPT-Omni: A Versatile Dental Multimodal Large Language Model](https://mlsanity.com/paper/2511.22055/) (2025)
- [Asynchronous Multimodal Video Sequence Fusion via Learning Modality-Exclusive and -Agnostic Representations](https://mlsanity.com/paper/2407.04955/) (2024)
- [MedGUIDE: Benchmarking Clinical Decision-Making in Large Language Models](https://mlsanity.com/paper/2505.11613/) (2025)
- [TECP: Token-Entropy Conformal Prediction for LLMs](https://mlsanity.com/paper/2509.00461/) (2025)
- [SAILViT: Towards Robust and Generalizable Visual Backbones for MLLMs via Gradual Feature Refinement](https://mlsanity.com/paper/2507.01643/) (2025)
- [Generative AI for Healthcare: Fundamentals, Challenges, and Perspectives](https://mlsanity.com/paper/2510.24551/) (2025)
- [Towards Democratization of Subspeciality Medical Expertise](https://mlsanity.com/paper/2410.03741/) (2024)
- [ClinBench-HPB: A Clinical Benchmark for Evaluating LLMs in Hepato-Pancreato-Biliary Diseases](https://mlsanity.com/paper/2506.00095/) (2025)
- [A Semi-Automated Annotation Workflow for Paediatric Histopathology Reports Using Small Language Models](https://mlsanity.com/paper/2604.04168/) (2026)
- [Applying Language Models in Clinical Medicine: Recent Trends and Perspectives](https://mlsanity.com/paper/2609.34780/) (2026)

## Abstract (arXiv)

Developing intelligent pediatric consultation systems offers promising prospects for improving diagnostic efficiency, especially in China, where healthcare resources are scarce. Despite recent advances in Large Language Models (LLMs) for Chinese medicine, their performance is sub-optimal in pediatric applications due to inadequate instruction data and vulnerable training procedures. To address the above issues, this paper builds PedCorpus, a high-quality dataset of over 300,000 multi-task instructions from pediatric textbooks, guidelines, and knowledge graph resources to fulfil diverse diagnostic demands. Upon well-designed PedCorpus, we propose PediatricsGPT, the first Chinese pediatric LLM assistant built on a systematic and robust training pipeline. In the continuous pre-training phase, we introduce a hybrid instruction pre-training mechanism to mitigate the internal-injected knowledge inconsistency of LLMs for medical domain adaptation. Immediately, the full-parameter Supervised Fine-Tuning (SFT) is utilized to incorporate the general medical knowledge schema into the models. After that, we devise a direct following preference optimization to enhance the generation of pediatrician-like humanistic responses. In the parameter-efficient secondary SFT phase, a mixture of universal-specific experts strategy is presented to resolve the competency conflict between medical generalist and pediatric expertise mastery. Extensive results based on the metrics, GPT-4, and doctor evaluations on distinct doctor downstream tasks show that PediatricsGPT consistently outperforms previous Chinese medical LLMs. Our model and dataset will be open-source for community development.