# Reconstructing Interpretable Features in Computational Super-Resolution microscopy via Regularized Latent Search

arXiv: https://arxiv.org/abs/2405.19112 · HTML: https://mlsanity.com/paper/2405.19112/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 15 of its 33 references that are in the map.
- First posted on arXiv 29 May 2024.

## Builds on (most cited first, 15 of 15)

- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [A Style-Based Generator Architecture for Generative Adversarial Networks](https://mlsanity.com/paper/1812.04948/) (2018)
- [Analyzing and Improving the Image Quality of StyleGAN](https://mlsanity.com/paper/1912.04958/) (2019)
- [Density estimation using Real NVP](https://mlsanity.com/paper/1605.08803/) (2016)
- [Normalizing Flows for Probabilistic Modeling and Inference](https://mlsanity.com/paper/1912.02762/) (2019)
- [Demystifying MMD GANs](https://mlsanity.com/paper/1801.01401/) (2018)
- [Training Generative Adversarial Networks with Limited Data](https://mlsanity.com/paper/2006.06676/) (2020)
- [Masked Autoregressive Flow for Density Estimation](https://mlsanity.com/paper/1705.07057/) (2017)
- [Image2StyleGAN: How to Embed Images Into the StyleGAN Latent Space?](https://mlsanity.com/paper/1904.03189/) (2019)
- [PULSE: Self-Supervised Photo Upsampling via Latent Space Exploration of Generative Models](https://mlsanity.com/paper/2003.03808/) (2020)
- [Compressed Sensing using Generative Models](https://mlsanity.com/paper/1703.03208/) (2017)
- [Improved StyleGAN Embedding: Where are the Good Latents?](https://mlsanity.com/paper/2012.09036/) (2020)
- [Improving Inversion and Generation Diversity in StyleGAN using a Gaussianized Latent Space](https://mlsanity.com/paper/2009.06529/) (2020)
- [Bayesian Image Reconstruction using Deep Generative Models](https://mlsanity.com/paper/2012.04567/) (2020)
- [Enhancing high-content imaging for studying microtubule networks at large-scale](https://mlsanity.com/paper/1910.00662/) (2019)

## Abstract (arXiv)

Supervised deep learning approaches can artificially increase the resolution of microscopy images by learning a mapping between two image resolutions or modalities. However, such methods often require a large set of hard-to-get low-res/high-res image pairs and produce synthetic images with a moderate increase in resolution. Conversely, recent methods based on GAN latent search offered a drastic increase in resolution without the need of paired images. However, they offer limited reconstruction of the high-resolution image interpretable features. Here, we propose a robust super-resolution method based on regularized latent search~(RLS) that offers an actionable balance between fidelity to the ground-truth and realism of the recovered image given a distribution prior. The latter allows to split the analysis of a low-resolution image into a computational super-resolution task performed by deep learning followed by a quantification task performed by a handcrafted algorithm and based on interpretable biological features. This two-step process holds potential for various applications such as diagnostics on mobile devices, where the main aim is not to recover the high-resolution details of a specific sample but rather to obtain high-resolution images that preserve explainable and quantifiable differences between conditions.