# A Classifier-Free Incremental Learning Framework for Scalable Medical Image Segmentation

arXiv: https://arxiv.org/abs/2405.16328 · HTML: https://mlsanity.com/paper/2405.16328/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 25 of its 34 references that are in the map.
- First posted on arXiv 25 May 2024.

## Builds on (most cited first, 25 of 25)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [Overcoming catastrophic forgetting in neural networks](https://mlsanity.com/paper/1612.00796/) (2016)
- [Learning without Forgetting](https://mlsanity.com/paper/1606.09282/) (2016)
- [iCaRL: Incremental Classifier and Representation Learning](https://mlsanity.com/paper/1611.07725/) (2016)
- [Progressive Neural Networks](https://mlsanity.com/paper/1606.04671/) (2016)
- [Continual Learning with Deep Generative Replay](https://mlsanity.com/paper/1705.08690/) (2017)
- [Memory Aware Synapses: Learning what (not) to forget](https://mlsanity.com/paper/1711.09601/) (2017)
- [Lifelong Learning with Dynamically Expandable Networks](https://mlsanity.com/paper/1708.01547/) (2017)
- [Expert Gate: Lifelong Learning with a Network of Experts](https://mlsanity.com/paper/1611.06194/) (2016)
- [AMOS: A Large-Scale Abdominal Multi-Organ Benchmark for Versatile Medical Image Segmentation](https://mlsanity.com/paper/2206.08023/) (2022)
- [ScribbleSup: Scribble-Supervised Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1604.05144/) (2016)
- [AbdomenCT-1K: Is Abdominal Organ Segmentation A Solved Problem?](https://mlsanity.com/paper/2010.14808/) (2020)
- [CLIP-Driven Universal Model for Organ Segmentation and Tumor Detection](https://mlsanity.com/paper/2301.00785/) (2023)
- [Modeling the Background for Incremental Learning in Semantic Segmentation](https://mlsanity.com/paper/2002.00718/) (2020)
- [DeepOrgan: Multi-level Deep Convolutional Networks for Automated Pancreas Segmentation](https://mlsanity.com/paper/1506.06448/) (2015)
- [SimpleClick: Interactive Image Segmentation with Simple Vision Transformers](https://mlsanity.com/paper/2210.11006/) (2022)
- [DoDNet: Learning to segment multi-organ and tumors from multiple partially labeled datasets](https://mlsanity.com/paper/2011.10217/) (2020)
- [DeepCut: Object Segmentation from Bounding Box Annotations using Convolutional Neural Networks](https://mlsanity.com/paper/1605.07866/) (2016)
- [Multi-organ Segmentation over Partially Labeled Datasets with Multi-scale Feature Abstraction](https://mlsanity.com/paper/2001.00208/) (2020)
- [Unleashing the Strengths of Unlabeled Data in Pan-cancer Abdominal Organ Quantification: the FLARE22 Challenge](https://mlsanity.com/paper/2308.05862/) (2023)
- [Self-Supervised Learning for Medical Image Data with Anatomy-Oriented Imaging Planes](https://mlsanity.com/paper/2403.16499/) (2024)
- [Versatile Medical Image Segmentation Learned from Multi-Source Datasets via Model Self-Disambiguation](https://mlsanity.com/paper/2311.10696/) (2023)
- [Incremental Learning for Multi-organ Segmentation with Partially Labeled Datasets](https://mlsanity.com/paper/2103.04526/) (2021)
- [Brain Tissue Segmentation Across the Human Lifespan via Supervised Contrastive Learning](https://mlsanity.com/paper/2301.01369/) (2023)

## Built on by (most cited first, 1 of 1)

- [Foundation Models as Class-Incremental Learners for Dermatological Image Classification](https://mlsanity.com/paper/2507.14050/) (2025)

## Abstract (arXiv)

Current methods for developing foundation models in medical image segmentation rely on two primary assumptions: a fixed set of classes and the immediate availability of a substantial and diverse training dataset. However, this can be impractical due to the evolving nature of imaging technology and patient demographics, as well as labor-intensive data curation, limiting their practical applicability and scalability. To address these challenges, we introduce a novel segmentation paradigm enabling the segmentation of a variable number of classes within a single classifier-free network, featuring an architecture independent of class number. This network is trained using contrastive learning and produces discriminative feature representations that facilitate straightforward interpretation. Additionally, we integrate this strategy into a knowledge distillation-based incremental learning framework, facilitating the gradual assimilation of new information from non-stationary data streams while avoiding catastrophic forgetting. Our approach provides a unified solution for tackling both class- and domain-incremental learning scenarios. We demonstrate the flexibility of our method in handling varying class numbers within a unified network and its capacity for incremental learning. Experimental results on an incompletely annotated, multi-modal, multi-source dataset for medical image segmentation underscore its superiority over state-of-the-art alternative approaches.