# Disease-informed Adaptation of Vision-Language Models

arXiv: https://arxiv.org/abs/2405.15728 · HTML: https://mlsanity.com/paper/2405.15728/

## Key facts

- Cited by 7 papers in the map (data through 14 Oct 2026).
- Placed in Medical vision-language models, one of 16 directions in Multimodal LLMs / vision-language models.
- Builds on 42 of its 66 references that are in the map.
- First posted on arXiv 24 May 2024.

## Placed in

- Multimodal LLMs / vision-language models / [Medical vision-language models](https://mlsanity.com/mllm/medical-vision-language-models/)

## Builds on (most cited first, 30 of 42)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [Neural Discrete Representation Learning](https://mlsanity.com/paper/1711.00937/) (2017)
- [Scaling Up Visual and Vision-Language Representation Learning With Noisy Text Supervision](https://mlsanity.com/paper/2102.05918/) (2021)
- [Learning to Prompt for Vision-Language Models](https://mlsanity.com/paper/2109.01134/) (2021)
- [Learn to Explain: Multimodal Reasoning via Thought Chains for Science Question Answering](https://mlsanity.com/paper/2209.09513/) (2022)
- [Microsoft COCO Captions: Data Collection and Evaluation Server](https://mlsanity.com/paper/1504.00325/) (2015)
- [Conditional Prompt Learning for Vision-Language Models](https://mlsanity.com/paper/2203.05557/) (2022)
- [CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparison](https://mlsanity.com/paper/1901.07031/) (2019)
- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [Grounded Language-Image Pre-training](https://mlsanity.com/paper/2112.03857/) (2021)
- [CLIP-Adapter: Better Vision-Language Models with Feature Adapters](https://mlsanity.com/paper/2110.04544/) (2021)
- [Publicly Available Clinical BERT Embeddings](https://mlsanity.com/paper/1904.03323/) (2019)
- [EDA: Easy Data Augmentation Techniques for Boosting Performance on Text Classification Tasks](https://mlsanity.com/paper/1901.11196/) (2019)
- [LISA: Reasoning Segmentation via Large Language Model](https://mlsanity.com/paper/2308.00692/) (2023)
- [MaPLe: Multi-modal Prompt Learning](https://mlsanity.com/paper/2210.03117/) (2022)
- [MedCLIP: Contrastive Learning from Unpaired Medical Images and Text](https://mlsanity.com/paper/2210.10163/) (2022)
- [Tip-Adapter: Training-free CLIP-Adapter for Better Vision-Language Modeling](https://mlsanity.com/paper/2111.03930/) (2021)
- [A Survey on Deep Transfer Learning](https://mlsanity.com/paper/1808.01974/) (2018)
- [Making the Most of Text Semantics to Improve Biomedical Vision--Language Processing](https://mlsanity.com/paper/2204.09817/) (2022)
- [Visual-Language Prompt Tuning with Knowledge-guided Context Optimization](https://mlsanity.com/paper/2303.13283/) (2023)
- [COVID-Net: A Tailored Deep Convolutional Neural Network Design for Detection of COVID-19 Cases from Chest X-Ray Images](https://mlsanity.com/paper/2003.09871/) (2020)
- [Can AI help in screening Viral and COVID-19 pneumonia?](https://mlsanity.com/paper/2003.13145/) (2020)
- [Cross-modal Memory Networks for Radiology Report Generation](https://mlsanity.com/paper/2204.13258/) (2022)
- [Multi-Granularity Cross-modal Alignment for Generalized Medical Visual Representation Learning](https://mlsanity.com/paper/2210.06044/) (2022)
- [Rank consistent ordinal regression for neural networks with application to age estimation](https://mlsanity.com/paper/1901.07884/) (2019)

## Built on by (most cited first, 7 of 7)

- [Fine-tuning Vision Language Models with Graph-based Knowledge for Explainable Medical Image Analysis](https://mlsanity.com/paper/2503.09808/) (2025)
- [Anatomy-Aware Low-Dose CT Denoising via Pretrained Vision Models and Semantic-Guided Contrastive Learning](https://mlsanity.com/paper/2508.07788/) (2025)
- [CLIP-IT: CLIP-based Pairing for Histology Images Classification](https://mlsanity.com/paper/2504.16181/) (2025)
- [Adapting Foundation Vision-Language Models to Medical Diagnosis via Query-Driven Expert Bridging](https://mlsanity.com/paper/2505.21698/) (2025)
- [CheXPO-v2: Preference Optimization for Chest X-ray VLMs with Knowledge Graph Consistency](https://mlsanity.com/paper/2512.17213/) (2025)
- [DECIS: Dual-Evidence Corrective Verification for Interpretable Strabismus Diagnostic Decision-Making](https://mlsanity.com/paper/2606.09249/) (2026)
- [RaLMPH: Reliability-aware Learning for Multi-Pathologist Harmonization in Whole-Slide Image Classification](https://mlsanity.com/paper/2606.15554/) (2026)

## Abstract (arXiv)

In medical image analysis, the expertise scarcity and the high cost of data annotation limits the development of large artificial intelligence models. This paper investigates the potential of transfer learning with pre-trained vision-language models (VLMs) in this domain. Currently, VLMs still struggle to transfer to the underrepresented diseases with minimal presence and new diseases entirely absent from the pretraining dataset. We argue that effective adaptation of VLMs hinges on the nuanced representation learning of disease concepts. By capitalizing on the joint visual-linguistic capabilities of VLMs, we introduce disease-informed contextual prompting in a novel disease prototype learning framework. This approach enables VLMs to grasp the concepts of new disease effectively and efficiently, even with limited data. Extensive experiments across multiple image modalities showcase notable enhancements in performance compared to existing techniques.