# A Mixture of Experts (MoE) model to improve AI-based computational pathology prediction performance under variable levels of histopathology image blur

arXiv: https://arxiv.org/abs/2405.09298 · HTML: https://mlsanity.com/paper/2405.09298/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical and biomedical MoE, one of 12 directions in Mixture-of-experts.
- Builds on 11 of its 48 references that are in the map.
- First posted on arXiv 15 May 2024.

## Placed in

- Mixture-of-experts / [Medical and biomedical MoE](https://mlsanity.com/moe/medical-and-biomedical-moe/)

## Builds on (most cited first, 11 of 11)

- [ImageNet Large Scale Visual Recognition Challenge](https://mlsanity.com/paper/1409.0575/) (2014)
- [Switch Transformers: Scaling to Trillion Parameter Models with Simple and Efficient Sparsity](https://mlsanity.com/paper/2101.03961/) (2021)
- [GLaM: Efficient Scaling of Language Models with Mixture-of-Experts](https://mlsanity.com/paper/2112.06905/) (2021)
- [Scaling Vision with Sparse Mixture of Experts](https://mlsanity.com/paper/2106.05974/) (2021)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [Multimodal Contrastive Learning with LIMoE: the Language-Image Mixture of Experts](https://mlsanity.com/paper/2206.02770/) (2022)
- [Understanding How Image Quality Affects Deep Neural Networks](https://mlsanity.com/paper/1604.04004/) (2016)
- [Predicting molecular phenotypes from histopathology images: a transcriptome-wide expression-morphology analysis in breast cancer](https://mlsanity.com/paper/2009.08917/) (2020)
- [A Comprehensive Survey of Convolutions in Deep Learning: Applications, Challenges, and Future Trends](https://mlsanity.com/paper/2402.15490/) (2024)
- [Whole-Slide Image Focus Quality: Automatic Assessment and Impact on AI Cancer Detection](https://mlsanity.com/paper/1901.04619/) (2019)
- [Focus Quality Assessment of High-Throughput Whole Slide Imaging in Digital Pathology](https://mlsanity.com/paper/1811.06038/) (2018)

## Abstract (arXiv)

AI-based models for histopathology whole slide image (WSI) analysis are increasingly common, but unsharp or blurred areas within WSI can significantly reduce prediction performance. In this study, we investigated the effect of image blur on deep learning models and introduced a mixture of experts (MoE) strategy that combines predictions from multiple expert models trained on data with varying blur levels. Using H&E-stained WSIs from 2,093 breast cancer patients, we benchmarked performance on grade classification and IHC biomarker prediction with both CNN- (CNN_CLAM and MoE-CNN_CLAM) and Vision Transformer-based (UNI_CLAM and MoE-UNI_CLAM) models. Our results show that baseline models' performance consistently decreased with increasing blur, but expert models trained on blurred tiles and especially our proposed MoE approach substantially improved performance, and outperformed baseline models in a range of simulated scenarios. MoE-CNN_CLAM outperformed the baseline CNN_CLAM under moderate (AUC: 0.868 vs. 0.702) and mixed blur conditions (AUC: 0.890 vs. 0.875). MoE-UNI_CLAM outperformed the baseline UNI_CLAM model in both moderate (AUC: 0.950 vs. 0.928) and mixed blur conditions (AUC: 0.944 vs. 0.931). This MoE method has the potential to enhance the reliability of AI-based pathology models under variable image quality, supporting broader application in both research and clinical settings.