# A Comprehensive Survey of Large Language Models and Multimodal Large Language Models in Medicine

arXiv: https://arxiv.org/abs/2405.08603 · HTML: https://mlsanity.com/paper/2405.08603/

## Key facts

- Cited by 45 papers in the map (data through 14 Oct 2026).
- Placed in Medical vision-language models, one of 16 directions in Multimodal LLMs / vision-language models.
- Builds on 190 of its 313 references that are in the map.
- First posted on arXiv 14 May 2024.

## Placed in

- Multimodal LLMs / vision-language models / [Medical vision-language models](https://mlsanity.com/mllm/medical-vision-language-models/)

## Builds on (most cited first, 30 of 190)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [RoBERTa: A Robustly Optimized BERT Pretraining Approach](https://mlsanity.com/paper/1907.11692/) (2019)
- [Llama 2: Open Foundation and Fine-Tuned Chat Models](https://mlsanity.com/paper/2307.09288/) (2023)
- [Judging LLM-as-a-Judge with MT-Bench and Chatbot Arena](https://mlsanity.com/paper/2306.05685/) (2023)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [Direct Preference Optimization: Your Language Model is Secretly a Reward Model](https://mlsanity.com/paper/2305.18290/) (2023)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Visual Instruction Tuning](https://mlsanity.com/paper/2304.08485/) (2023)
- [Scaling Laws for Neural Language Models](https://mlsanity.com/paper/2001.08361/) (2020)
- [BLIP-2: Bootstrapping Language-Image Pre-training with Frozen Image Encoders and Large Language Models](https://mlsanity.com/paper/2301.12597/) (2023)
- [Self-Consistency Improves Chain of Thought Reasoning in Language Models](https://mlsanity.com/paper/2203.11171/) (2022)
- [BERTScore: Evaluating Text Generation with BERT](https://mlsanity.com/paper/1904.09675/) (2019)
- [PaLM: Scaling Language Modeling with Pathways](https://mlsanity.com/paper/2204.02311/) (2022)
- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [Improved Baselines with Visual Instruction Tuning](https://mlsanity.com/paper/2310.03744/) (2023)
- [Flamingo: a Visual Language Model for Few-Shot Learning](https://mlsanity.com/paper/2204.14198/) (2022)
- [Large Language Models are Zero-Shot Reasoners](https://mlsanity.com/paper/2205.11916/) (2022)
- [Parameter-Efficient Transfer Learning for NLP](https://mlsanity.com/paper/1902.00751/) (2019)
- [Robust Speech Recognition via Large-Scale Weak Supervision](https://mlsanity.com/paper/2212.04356/) (2022)
- [Prefix-Tuning: Optimizing Continuous Prompts for Generation](https://mlsanity.com/paper/2101.00190/) (2021)
- [The Power of Scale for Parameter-Efficient Prompt Tuning](https://mlsanity.com/paper/2104.08691/) (2021)

## Built on by (most cited first, 30 of 45)

- [SkySenseGPT: A Fine-Grained Instruction Tuning Dataset and Model for Remote Sensing Vision-Language Understanding](https://mlsanity.com/paper/2406.10100/) (2024)
- [MultiTrust: A Comprehensive Benchmark Towards Trustworthy Multimodal Large Language Models](https://mlsanity.com/paper/2406.07057/) (2024)
- [Explainable and Interpretable Multimodal Large Language Models: A Comprehensive Survey](https://mlsanity.com/paper/2412.02104/) (2024)
- [ErrorRadar: Benchmarking Complex Mathematical Reasoning of Multimodal Large Language Models Via Error Detection](https://mlsanity.com/paper/2410.04509/) (2024)
- [Membership Inference Attacks Against Vision-Language Models](https://mlsanity.com/paper/2501.18624/) (2025)
- [UrBench: A Comprehensive Benchmark for Evaluating Large Multimodal Models in Multi-View Urban Scenarios](https://mlsanity.com/paper/2408.17267/) (2024)
- [Towards a Personal Health Large Language Model](https://mlsanity.com/paper/2406.06474/) (2024)
- [[CLS] Token Tells Everything Needed for Training-free Efficient MLLMs](https://mlsanity.com/paper/2412.05819/) (2024)
- [From Specific-MLLMs to Omni-MLLMs: A Survey on MLLMs Aligned with Multi-modalities](https://mlsanity.com/paper/2412.11694/) (2024)
- [MedAide: Information Fusion and Anatomy of Medical Intents via LLM-based Agent Collaboration](https://mlsanity.com/paper/2410.12532/) (2024)
- [Multimodal Large Language Models for Medicine: A Comprehensive Survey](https://mlsanity.com/paper/2504.21051/) (2025)
- [Simulated patient systems powered by large language model-based AI agents offer potential for transforming medical education](https://mlsanity.com/paper/2409.18924/) (2024)
- [mCLM: A Modular Chemical Language Model that Generates Functional and Makeable Molecules](https://mlsanity.com/paper/2505.12565/) (2025)
- [Odysseus: Jailbreaking Commercial Multimodal LLM-integrated Systems via Dual Steganography](https://mlsanity.com/paper/2512.20168/) (2025)
- [LMOD: A Large Multimodal Ophthalmology Dataset and Benchmark for Large Vision-Language Models](https://mlsanity.com/paper/2410.01620/) (2024)
- [MINER: Mining the Underlying Pattern of Modality-Specific Neurons in Multimodal Large Language Models](https://mlsanity.com/paper/2410.04819/) (2024)
- [Applications of Large Models in Medicine](https://mlsanity.com/paper/2502.17132/) (2025)
- [UniVRSE: Unified Vision-conditioned Response Semantic Entropy for Hallucination Detection in Medical Vision-Language Models](https://mlsanity.com/paper/2503.20504/) (2025)
- [EVADE-Bench: Multimodal Benchmark for Evaluating and Enhancing Evasive Content Detection](https://mlsanity.com/paper/2505.17654/) (2025)
- [Large Language Models for Bioinformatics](https://mlsanity.com/paper/2501.06271/) (2025)
- [Look & Mark: Leveraging Radiologist Eye Fixations and Bounding boxes in Multimodal Large Language Models for Chest X-ray Report Generation](https://mlsanity.com/paper/2505.22222/) (2025)
- [Large Language models for Time Series Analysis: Techniques, Applications, and Challenges](https://mlsanity.com/paper/2506.11040/) (2025)
- [The Judgment-Consequence Gap: LLM Moral Reasoning in Healthcare Decisions](https://mlsanity.com/paper/2608.05583/) (2026)
- [Who Gets the Kidney? Human-AI Alignment, Indecision, and Moral Values](https://mlsanity.com/paper/2506.00079/) (2025)
- [MedMKEB: A Comprehensive Knowledge Editing Benchmark for Medical Multimodal Large Language Models](https://mlsanity.com/paper/2508.05083/) (2025)
- [Direct Token Optimization: A Self-contained Approach to Large Language Model Unlearning](https://mlsanity.com/paper/2510.00125/) (2025)
- [Perceive and Calibrate: Analyzing and Enhancing Robustness of Medical Multi-Modal Large Language Models](https://mlsanity.com/paper/2512.21964/) (2025)
- [Fairness in Multi-modal Medical Diagnosis with Demonstration Selection](https://mlsanity.com/paper/2511.15986/) (2025)
- [AnatomiX, an Anatomy-Aware Grounded Multimodal Large Language Model for Chest X-Ray Interpretation](https://mlsanity.com/paper/2601.03191/) (2026)
- [Measuring Cross-Modal Synergy: A Benchmark for VLM Explainability](https://mlsanity.com/paper/2605.22168/) (2026)

## Abstract (arXiv)

Since the release of ChatGPT and GPT-4, large language models (LLMs) and multimodal large language models (MLLMs) have attracted widespread attention for their exceptional capabilities in understanding, reasoning, and generation, introducing transformative paradigms for integrating artificial intelligence into medicine. This survey provides a comprehensive overview of the development, principles, application scenarios, challenges, and future directions of LLMs and MLLMs in medicine. Specifically, it begins by examining the paradigm shift, tracing the transition from traditional models to LLMs and MLLMs, and highlighting the unique advantages of these LLMs and MLLMs in medical applications. Next, the survey reviews existing medical LLMs and MLLMs, providing detailed guidance on their construction and evaluation in a clear and systematic manner. Subsequently, to underscore the substantial value of LLMs and MLLMs in healthcare, the survey explores five promising applications in the field. Finally, the survey addresses the challenges confronting medical LLMs and MLLMs and proposes practical strategies and future directions for their integration into medicine. In summary, this survey offers a comprehensive analysis of the technical methodologies and practical clinical applications of medical LLMs and MLLMs, with the goal of bridging the gap between these advanced technologies and clinical practice, thereby fostering the evolution of the next generation of intelligent healthcare systems.