# HC-Mamba: Vision MAMBA with Hybrid Convolutional Techniques for Medical Image Segmentation

arXiv: https://arxiv.org/abs/2405.05007 · HTML: https://mlsanity.com/paper/2405.05007/

## Key facts

- Cited by 15 papers in the map (data through 14 Oct 2026).
- Placed in Mamba for medical image analysis, one of 10 directions in State-space sequence models (S4, Mamba).
- Builds on 21 of its 26 references that are in the map.
- First posted on arXiv 8 May 2024.

## Placed in

- State-space sequence models (S4, Mamba) / [Mamba for medical image analysis](https://mlsanity.com/ssm/mamba-for-medical-image-analysis/)

## Builds on (most cited first, 21 of 21)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [Xception: Deep Learning with Depthwise Separable Convolutions](https://mlsanity.com/paper/1610.02357/) (2016)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [A Survey on Deep Learning in Medical Image Analysis](https://mlsanity.com/paper/1702.05747/) (2017)
- [Multi-Scale Context Aggregation by Dilated Convolutions](https://mlsanity.com/paper/1511.07122/) (2015)
- [Skin Lesion Analysis Toward Melanoma Detection 2018: A Challenge Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1902.03368/) (2019)
- [Hungry Hungry Hippos: Towards Language Modeling with State Space Models](https://mlsanity.com/paper/2212.14052/) (2022)
- [U-Mamba: Enhancing Long-range Dependency for Biomedical Image Segmentation](https://mlsanity.com/paper/2401.04722/) (2024)
- [TransFuse: Fusing Transformers and CNNs for Medical Image Segmentation](https://mlsanity.com/paper/2102.08005/) (2021)
- [It's Raw! Audio Generation with State-Space Models](https://mlsanity.com/paper/2202.09729/) (2022)
- [ChatCAD: Interactive Computer-Aided Diagnosis on Medical Image using Large Language Models](https://mlsanity.com/paper/2302.07257/) (2023)
- [Shallow Attention Network for Polyp Segmentation](https://mlsanity.com/paper/2108.00882/) (2021)
- [Recent advances and clinical applications of deep learning in medical image analysis](https://mlsanity.com/paper/2105.13381/) (2021)
- [MALUNet: A Multi-Attention and Light-weight UNet for Skin Lesion Segmentation](https://mlsanity.com/paper/2211.01784/) (2022)

## Built on by (most cited first, 15 of 15)

- [Mamba in Vision: A Comprehensive Survey of Techniques and Applications](https://mlsanity.com/paper/2410.03105/) (2024)
- [A Comprehensive Survey of Mamba Architectures for Medical Image Analysis: Classification, Segmentation, Restoration and Beyond](https://mlsanity.com/paper/2410.02362/) (2024)
- [SliceMamba with Neural Architecture Search for Medical Image Segmentation](https://mlsanity.com/paper/2407.08481/) (2024)
- [Mamba-Sea: A Mamba-based Framework with Global-to-Local Sequence Augmentation for Generalizable Medical Image Segmentation](https://mlsanity.com/paper/2504.17515/) (2025)
- [Merging Context Clustering with Visual State Space Models for Medical Image Segmentation](https://mlsanity.com/paper/2501.01618/) (2025)
- [Med-TTT: Vision Test-Time Training model for Medical Image Segmentation](https://mlsanity.com/paper/2410.02523/) (2024)
- [Na-IRSTD: Enhancing Infrared Small Target Detection via Native-Resolution Feature Selection and Fusion](https://mlsanity.com/paper/2605.05804/) (2026)
- [FAN-Unet: Enhancing Unet with vision Fourier Analysis Block for Biomedical Image Segmentation](https://mlsanity.com/paper/2411.18975/) (2024)
- [MedSegNet10: A Publicly Accessible Network Repository for Split Federated Medical Image Segmentation](https://mlsanity.com/paper/2503.20830/) (2025)
- [ACM-UNet: Adaptive Integration of CNNs and Mamba for Efficient Medical Image Segmentation](https://mlsanity.com/paper/2505.24481/) (2025)
- [WDFFU-Mamba: A Wavelet-guided Dual-attention Feature Fusion Mamba for Breast Tumor Segmentation in Ultrasound Images](https://mlsanity.com/paper/2512.17278/) (2025)
- [DB-MSMUNet:Dual Branch Multi-scale Mamba UNet for Pancreatic CT Scans Segmentation](https://mlsanity.com/paper/2601.04676/) (2026)
- [Decoding Matters: Efficient Mamba-Based Decoder with Distribution-Aware Deep Supervision for Medical Image Segmentation](https://mlsanity.com/paper/2603.12547/) (2026)
- [CS-MUNet: A Channel-Spatial Dual-Stream Mamba Network for Multi-Organ Segmentation](https://mlsanity.com/paper/2603.19659/) (2026)
- [APRIL-MedSeg: A Modular Medical Image Segmentation Toolbox Embracing Modern Paradigms](https://mlsanity.com/paper/2606.30577/) (2026)

## Abstract (arXiv)

Automatic medical image segmentation technology has the potential to expedite pathological diagnoses, thereby enhancing the efficiency of patient care. However, medical images often have complex textures and structures, and the models often face the problem of reduced image resolution and information loss due to downsampling. To address this issue, we propose HC-Mamba, a new medical image segmentation model based on the modern state space model Mamba. Specifically, we introduce the technique of dilated convolution in the HC-Mamba model to capture a more extensive range of contextual information without increasing the computational cost by extending the perceptual field of the convolution kernel. In addition, the HC-Mamba model employs depthwise separable convolutions, significantly reducing the number of parameters and the computational power of the model. By combining dilated convolution and depthwise separable convolutions, HC-Mamba is able to process large-scale medical image data at a much lower computational cost while maintaining a high level of performance. We conduct comprehensive experiments on segmentation tasks including organ segmentation and skin lesion, and conduct extensive experiments on Synapse, ISIC17 and ISIC18 to demonstrate the potential of the HC-Mamba model in medical image segmentation. The experimental results show that HC-Mamba exhibits competitive performance on all these datasets, thereby proving its effectiveness and usefulness in medical image segmentation.