# DALK: Dynamic Co-Augmentation of LLMs and KG to answer Alzheimer's Disease Questions with Scientific Literature

arXiv: https://arxiv.org/abs/2405.04819 · HTML: https://mlsanity.com/paper/2405.04819/

## Key facts

- Cited by 50 papers in the map (data through 14 Oct 2026).
- Builds on 38 of its 70 references that are in the map.
- First posted on arXiv 8 May 2024.

## Builds on (most cited first, 30 of 38)

- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Llama 2: Open Foundation and Fine-Tuned Chat Models](https://mlsanity.com/paper/2307.09288/) (2023)
- [Sentence-BERT: Sentence Embeddings using Siamese BERT-Networks](https://mlsanity.com/paper/1908.10084/) (2019)
- [Judging LLM-as-a-Judge with MT-Bench and Chatbot Arena](https://mlsanity.com/paper/2306.05685/) (2023)
- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [Self-Consistency Improves Chain of Thought Reasoning in Language Models](https://mlsanity.com/paper/2203.11171/) (2022)
- [OPT: Open Pre-trained Transformer Language Models](https://mlsanity.com/paper/2205.01068/) (2022)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [ConceptNet 5.5: An Open Multilingual Graph of General Knowledge](https://mlsanity.com/paper/1612.03975/) (2016)
- [Self-Rewarding Language Models](https://mlsanity.com/paper/2401.10020/) (2024)
- [Unifying Large Language Models and Knowledge Graphs: A Roadmap](https://mlsanity.com/paper/2306.08302/) (2023)
- [StructGPT: A General Framework for Large Language Model to Reason over Structured Data](https://mlsanity.com/paper/2305.09645/) (2023)
- [BioMistral: A Collection of Open-Source Pretrained Large Language Models for Medical Domains](https://mlsanity.com/paper/2402.10373/) (2024)
- [Automatically Correcting Large Language Models: Surveying the landscape of diverse self-correction strategies](https://mlsanity.com/paper/2308.03188/) (2023)
- [Chain-of-Note: Enhancing Robustness in Retrieval-Augmented Language Models](https://mlsanity.com/paper/2311.09210/) (2023)
- [Fine-Tuning or Retrieval? Comparing Knowledge Injection in LLMs](https://mlsanity.com/paper/2312.05934/) (2023)
- [Almanac: Retrieval-Augmented Language Models for Clinical Medicine](https://mlsanity.com/paper/2303.01229/) (2023)
- [Large Language Model Is Not a Good Few-shot Information Extractor, but a Good Reranker for Hard Samples!](https://mlsanity.com/paper/2303.08559/) (2023)
- [ASER: A Large-scale Eventuality Knowledge Graph](https://mlsanity.com/paper/1905.00270/) (2019)
- [Clinical Camel: An Open Expert-Level Medical Language Model with Dialogue-Based Knowledge Encoding](https://mlsanity.com/paper/2305.12031/) (2023)
- [Can LLMs Learn from Previous Mistakes? Investigating LLMs' Errors to Boost for Reasoning](https://mlsanity.com/paper/2403.20046/) (2024)
- [To BERT or Not To BERT: Comparing Speech and Language-based Approaches for Alzheimer's Disease Detection](https://mlsanity.com/paper/2008.01551/) (2020)
- [PiVe: Prompting with Iterative Verification Improving Graph-based Generative Capability of LLMs](https://mlsanity.com/paper/2305.12392/) (2023)
- [Clinfo.ai: An Open-Source Retrieval-Augmented Large Language Model System for Answering Medical Questions using Scientific Literature](https://mlsanity.com/paper/2310.16146/) (2023)
- [DISCOS: Bridging the Gap between Discourse Knowledge and Commonsense Knowledge](https://mlsanity.com/paper/2101.00154/) (2021)
- [Two Directions for Clinical Data Generation with Large Language Models: Data-to-Label and Label-to-Data](https://mlsanity.com/paper/2401.06774/) (2023)
- [TEILP: Time Prediction over Knowledge Graphs via Logical Reasoning](https://mlsanity.com/paper/2312.15816/) (2023)
- [TILP: Differentiable Learning of Temporal Logical Rules on Knowledge Graphs](https://mlsanity.com/paper/2402.12309/) (2024)

## Built on by (most cited first, 30 of 50)

- [From Generation to Judgment: Opportunities and Challenges of LLM-as-a-judge](https://mlsanity.com/paper/2411.16594/) (2024)
- [Graph Retrieval-Augmented Generation: A Survey](https://mlsanity.com/paper/2408.08921/) (2024)
- [Retrieval-Augmented Generation with Graphs (GraphRAG)](https://mlsanity.com/paper/2501.00309/) (2024)
- [Preference Leakage: A Contamination Problem in LLM-as-a-judge](https://mlsanity.com/paper/2502.01534/) (2025)
- [KAG: Boosting LLMs in Professional Domains via Knowledge Augmented Generation](https://mlsanity.com/paper/2409.13731/) (2024)
- [Injecting Domain-Specific Knowledge into Large Language Models: A Comprehensive Survey](https://mlsanity.com/paper/2502.10708/) (2025)
- [In-depth Analysis of Graph-based RAG in a Unified Framework](https://mlsanity.com/paper/2503.04338/) (2025)
- [Evaluating Scoring Bias in LLM-as-a-Judge](https://mlsanity.com/paper/2506.22316/) (2025)
- [Towards Agentic RAG with Deep Reasoning: A Survey of RAG-Reasoning Systems in LLMs](https://mlsanity.com/paper/2507.09477/) (2025)
- [SMoA: Improving Multi-agent Large Language Models with Sparse Mixture-of-Agents](https://mlsanity.com/paper/2411.03284/) (2024)
- [KET-RAG: A Cost-Efficient Multi-Granular Indexing Framework for Graph-RAG](https://mlsanity.com/paper/2502.09304/) (2025)
- [ArchRAG: Attributed Community-based Hierarchical Retrieval-Augmented Generation](https://mlsanity.com/paper/2502.09891/) (2025)
- [Exploring Large Language Models for Feature Selection: A Data-centric Perspective](https://mlsanity.com/paper/2408.12025/) (2024)
- [GraphRAG-Bench: Challenging Domain-Specific Reasoning for Evaluating Graph Retrieval-Augmented Generation](https://mlsanity.com/paper/2506.02404/) (2025)
- [BPO: Towards Balanced Preference Optimization between Knowledge Breadth and Depth in Alignment](https://mlsanity.com/paper/2411.10914/) (2024)
- [RAG-Enhanced Collaborative LLM Agents for Drug Discovery](https://mlsanity.com/paper/2502.17506/) (2025)
- [BookRAG: A Hierarchical Structure-aware Index-based Approach for Retrieval-Augmented Generation on Complex Documents](https://mlsanity.com/paper/2512.03413/) (2025)
- [GraphRAG-R1: Graph Retrieval-Augmented Generation with Process-Constrained Reinforcement Learning](https://mlsanity.com/paper/2507.23581/) (2025)
- [Memory in the LLM Era: Modular Architectures and Strategies in a Unified Framework](https://mlsanity.com/paper/2604.01707/) (2026)
- [DLO: Dynamic Layer Operation for Efficient Vertical Scaling of LLMs](https://mlsanity.com/paper/2407.11030/) (2024)
- [Quantifying and Improving the Robustness of Retrieval-Augmented Language Models Against Spurious Features in Grounding Data](https://mlsanity.com/paper/2503.05587/) (2025)
- [LAG: Logic-Augmented Generation from a Cartesian Perspective](https://mlsanity.com/paper/2508.05509/) (2025)
- [Knowledge-Driven Feature Selection and Engineering for Genotype Data with Large Language Models](https://mlsanity.com/paper/2410.01795/) (2024)
- [Time Matters: Examine Temporal Effects on Biomedical Language Models](https://mlsanity.com/paper/2407.17638/) (2024)
- [Beyond Accuracy: The Role of Calibration in Self-Improving Large Language Models](https://mlsanity.com/paper/2504.02902/) (2025)
- [GuiLoMo: Allocating Expert Number and Rank for LoRA-MoE via Bilevel Optimization with GuidedSelection Vectors](https://mlsanity.com/paper/2506.14646/) (2025)
- [From Promising Capability to Pervasive Bias: Assessing Large Language Models for Emergency Department Triage](https://mlsanity.com/paper/2504.16273/) (2025)
- [MedKGent: A Large Language Model Agent Framework for Constructing Temporally Evolving Medical Knowledge Graph](https://mlsanity.com/paper/2508.12393/) (2025)
- [Fostering Natural Conversation in Large Language Models with NICO: a Natural Interactive COnversation dataset](https://mlsanity.com/paper/2408.09330/) (2024)
- [Examining Imbalance Effects on Performance and Demographic Fairness of Clinical Language Models](https://mlsanity.com/paper/2412.17803/) (2024)

## Abstract (arXiv)

Recent advancements in large language models (LLMs) have achieved promising performances across various applications. Nonetheless, the ongoing challenge of integrating long-tail knowledge continues to impede the seamless adoption of LLMs in specialized domains. In this work, we introduce DALK, a.k.a. Dynamic Co-Augmentation of LLMs and KG, to address this limitation and demonstrate its ability on studying Alzheimer's Disease (AD), a specialized sub-field in biomedicine and a global health priority. With a synergized framework of LLM and KG mutually enhancing each other, we first leverage LLM to construct an evolving AD-specific knowledge graph (KG) sourced from AD-related scientific literature, and then we utilize a coarse-to-fine sampling method with a novel self-aware knowledge retrieval approach to select appropriate knowledge from the KG to augment LLM inference capabilities. The experimental results, conducted on our constructed AD question answering (ADQA) benchmark, underscore the efficacy of DALK. Additionally, we perform a series of detailed analyses that can offer valuable insights and guidelines for the emerging topic of mutually enhancing KG and LLM. We will release the code and data at https://github.com/David-Li0406/DALK.