# Guided Conditional Diffusion Classifier (ConDiff) for Enhanced Prediction of Infection in Diabetic Foot Ulcers

arXiv: https://arxiv.org/abs/2405.00858 · HTML: https://mlsanity.com/paper/2405.00858/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 32 of its 55 references that are in the map.
- First posted on arXiv 1 May 2024.

## Builds on (most cited first, 30 of 32)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [Scalable Diffusion Models with Transformers](https://mlsanity.com/paper/2212.09748/) (2022)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [Training data-efficient image transformers & distillation through attention](https://mlsanity.com/paper/2012.12877/) (2020)
- [Going Deeper with Convolutions](https://mlsanity.com/paper/1409.4842/) (2014)
- [Generative Modeling by Estimating Gradients of the Data Distribution](https://mlsanity.com/paper/1907.05600/) (2019)
- [GLIDE: Towards Photorealistic Image Generation and Editing with Text-Guided Diffusion Models](https://mlsanity.com/paper/2112.10741/) (2021)
- [Improved Techniques for Training GANs](https://mlsanity.com/paper/1606.03498/) (2016)
- [FaceNet: A Unified Embedding for Face Recognition and Clustering](https://mlsanity.com/paper/1503.03832/) (2015)
- [Conditional Generative Adversarial Nets](https://mlsanity.com/paper/1411.1784/) (2014)
- [SDEdit: Guided Image Synthesis and Editing with Stochastic Differential Equations](https://mlsanity.com/paper/2108.01073/) (2021)
- [LAION-400M: Open Dataset of CLIP-Filtered 400 Million Image-Text Pairs](https://mlsanity.com/paper/2111.02114/) (2021)
- [Swin Transformer V2: Scaling Up Capacity and Resolution](https://mlsanity.com/paper/2111.09883/) (2021)
- [Adversarial Diffusion Distillation](https://mlsanity.com/paper/2311.17042/) (2023)
- [Score-CAM: Score-Weighted Visual Explanations for Convolutional Neural Networks](https://mlsanity.com/paper/1910.01279/) (2019)
- [EfficientFormer: Vision Transformers at MobileNet Speed](https://mlsanity.com/paper/2206.01191/) (2022)
- [Unsupervised Medical Image Translation with Adversarial Diffusion Models](https://mlsanity.com/paper/2207.08208/) (2022)
- [MedSegDiff: Medical Image Segmentation with Diffusion Probabilistic Model](https://mlsanity.com/paper/2211.00611/) (2022)
- [InverseSR: 3D Brain MRI Super-Resolution Using a Latent Diffusion Model](https://mlsanity.com/paper/2308.12465/) (2023)
- [Recognition of Ischaemia and Infection in Diabetic Foot Ulcers: Dataset and Techniques](https://mlsanity.com/paper/1908.05317/) (2019)
- [Analysis Towards Classification of Infection and Ischaemia of Diabetic Foot Ulcers](https://mlsanity.com/paper/2104.03068/) (2021)

## Abstract (arXiv)

To detect infected wounds in Diabetic Foot Ulcers (DFUs) from photographs, preventing severe complications and amputations. Methods: This paper proposes the Guided Conditional Diffusion Classifier (ConDiff), a novel deep-learning infection detection model that combines guided image synthesis with a denoising diffusion model and distance-based classification. The process involves (1) generating guided conditional synthetic images by injecting Gaussian noise to a guide image, followed by denoising the noise-perturbed image through a reverse diffusion process, conditioned on infection status and (2) classifying infections based on the minimum Euclidean distance between synthesized images and the original guide image in embedding space. Results: ConDiff demonstrated superior performance with an accuracy of 83% and an F1-score of 0.858, outperforming state-of-the-art models by at least 3%. The use of a triplet loss function reduces overfitting in the distance-based classifier. Conclusions: ConDiff not only enhances diagnostic accuracy for DFU infections but also pioneers the use of generative discriminative models for detailed medical image analysis, offering a promising approach for improving patient outcomes.