# X-Diffusion: Generating Detailed 3D MRI Volumes From a Single Image Using Cross-Sectional Diffusion Models

arXiv: https://arxiv.org/abs/2404.19604 · HTML: https://mlsanity.com/paper/2404.19604/

## Key facts

- Cited by 5 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 58 of its 99 references that are in the map.
- First posted on arXiv 30 Apr 2024.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 30 of 58)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding](https://mlsanity.com/paper/2205.11487/) (2022)
- [SDXL: Improving Latent Diffusion Models for High-Resolution Image Synthesis](https://mlsanity.com/paper/2307.01952/) (2023)
- [DreamFusion: Text-to-3D using 2D Diffusion](https://mlsanity.com/paper/2209.14988/) (2022)
- [Stable Video Diffusion: Scaling Latent Video Diffusion Models to Large Datasets](https://mlsanity.com/paper/2311.15127/) (2023)
- [Mip-NeRF 360: Unbounded Anti-Aliased Neural Radiance Fields](https://mlsanity.com/paper/2111.12077/) (2021)
- [Mip-NeRF: A Multiscale Representation for Anti-Aliasing Neural Radiance Fields](https://mlsanity.com/paper/2103.13415/) (2021)
- [pixelNeRF: Neural Radiance Fields from One or Few Images](https://mlsanity.com/paper/2012.02190/) (2020)
- [Objaverse: A Universe of Annotated 3D Objects](https://mlsanity.com/paper/2212.08051/) (2022)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [Zero-1-to-3: Zero-shot One Image to 3D Object](https://mlsanity.com/paper/2303.11328/) (2023)
- [Magic3D: High-Resolution Text-to-3D Content Creation](https://mlsanity.com/paper/2211.10440/) (2022)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [Denoising Diffusion Restoration Models](https://mlsanity.com/paper/2201.11793/) (2022)
- [Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Images](https://mlsanity.com/paper/2201.01266/) (2022)
- [Fantasia3D: Disentangling Geometry and Appearance for High-quality Text-to-3D Content Creation](https://mlsanity.com/paper/2303.13873/) (2023)
- [Ref-NeRF: Structured View-Dependent Appearance for Neural Radiance Fields](https://mlsanity.com/paper/2112.03907/) (2021)
- [Multi-view Convolutional Neural Networks for 3D Shape Recognition](https://mlsanity.com/paper/1505.00880/) (2015)
- [The RSNA-ASNR-MICCAI BraTS 2021 Benchmark on Brain Tumor Segmentation and Radiogenomic Classification](https://mlsanity.com/paper/2107.02314/) (2021)
- [Zero-Shot Text-Guided Object Generation with Dream Fields](https://mlsanity.com/paper/2112.01455/) (2021)
- [Improving Diffusion Models for Inverse Problems using Manifold Constraints](https://mlsanity.com/paper/2206.00941/) (2022)
- [fastMRI: An Open Dataset and Benchmarks for Accelerated MRI](https://mlsanity.com/paper/1811.08839/) (2018)
- [Putting NeRF on a Diet: Semantically Consistent Few-Shot View Synthesis](https://mlsanity.com/paper/2104.00677/) (2021)
- [Self-Supervised Pre-Training of Swin Transformers for 3D Medical Image Analysis](https://mlsanity.com/paper/2111.14791/) (2021)
- [Magic123: One Image to High-Quality 3D Object Generation Using Both 2D and 3D Diffusion Priors](https://mlsanity.com/paper/2306.17843/) (2023)

## Built on by (most cited first, 5 of 5)

- [UKBOB: One Billion MRI Labeled Masks for Generalizable 3D Medical Image Segmentation](https://mlsanity.com/paper/2504.06908/) (2025)
- [X-ray2CTPA: Leveraging Diffusion Models to Enhance Pulmonary Embolism Classification](https://mlsanity.com/paper/2406.16109/) (2024)
- [Interpretable Motion Artificat Detection in structural Brain MRI](https://mlsanity.com/paper/2603.05726/) (2026)
- [Single-Slice-to-3D Reconstruction in Medical Imaging and Natural Objects: A Comparative Benchmark with SAM 3D](https://mlsanity.com/paper/2602.09407/) (2026)
- [MK-ResRecon: Multi-Kernel Residual Framework for Texture-Aware 3D MRI Refinement from Sparse 2D Slices](https://mlsanity.com/paper/2605.03432/) (2026)

## Abstract (arXiv)

Magnetic Resonance Imaging (MRI) is a crucial diagnostic tool, but high-resolution scans are often slow and expensive due to extensive data acquisition requirements. Traditional MRI reconstruction methods aim to expedite this process by filling in missing frequency components in the K-space, performing 3D-to-3D reconstructions that demand full 3D scans. In contrast, we introduce X-Diffusion, a novel cross-sectional diffusion model that reconstructs detailed 3D MRI volumes from extremely sparse spatial-domain inputs, achieving 2D-to-3D reconstruction from as little as a single 2D MRI slice or few slices. A key aspect of X-Diffusion is that it models MRI data as holistic 3D volumes during the cross-sectional training and inference, unlike previous learning approaches that treat MRI scans as collections of 2D slices in standard planes (coronal, axial, sagittal). We evaluated X-Diffusion on brain tumor MRIs from the BRATS dataset and full-body MRIs from the UK Biobank dataset. Our results demonstrate that X-Diffusion not only surpasses state-of-the-art methods in quantitative accuracy (PSNR) on unseen data but also preserves critical anatomical features such as tumor profiles, spine curvature, and brain volume. Remarkably, the model generalizes beyond the training domain, successfully reconstructing knee MRIs despite being trained exclusively on brain data. Medical expert evaluations further confirm the clinical relevance and fidelity of the generated images. To our knowledge, X-Diffusion is the first method capable of producing detailed 3D MRIs from highly limited 2D input data, potentially accelerating MRI acquisition and reducing associated costs. The code is available on the project website https://emmanuelleb985.github.io/XDiffusion/ .