# A Comprehensive Survey on Evaluating Large Language Model Applications in the Medical Industry

arXiv: https://arxiv.org/abs/2404.15777 · HTML: https://mlsanity.com/paper/2404.15777/

## Key facts

- Cited by 17 papers in the map (data through 14 Oct 2026).
- Builds on 76 of its 176 references that are in the map.
- First posted on arXiv 24 Apr 2024.

## Builds on (most cited first, 30 of 76)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [RoBERTa: A Robustly Optimized BERT Pretraining Approach](https://mlsanity.com/paper/1907.11692/) (2019)
- [Llama 2: Open Foundation and Fine-Tuned Chat Models](https://mlsanity.com/paper/2307.09288/) (2023)
- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [DistilBERT, a distilled version of BERT: smaller, faster, cheaper and lighter](https://mlsanity.com/paper/1910.01108/) (2019)
- [OPT: Open Pre-trained Transformer Language Models](https://mlsanity.com/paper/2205.01068/) (2022)
- [Scaling Instruction-Finetuned Language Models](https://mlsanity.com/paper/2210.11416/) (2022)
- [ALBERT: A Lite BERT for Self-supervised Learning of Language Representations](https://mlsanity.com/paper/1909.11942/) (2019)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [SciBERT: A Pretrained Language Model for Scientific Text](https://mlsanity.com/paper/1903.10676/) (2019)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [BEIR: A Heterogenous Benchmark for Zero-shot Evaluation of Information Retrieval Models](https://mlsanity.com/paper/2104.08663/) (2021)
- [A Survey on Evaluation of Large Language Models](https://mlsanity.com/paper/2307.03109/) (2023)
- [LaMDA: Language Models for Dialog Applications](https://mlsanity.com/paper/2201.08239/) (2022)
- [PaLM 2 Technical Report](https://mlsanity.com/paper/2305.10403/) (2023)
- [When Not to Trust Language Models: Investigating Effectiveness of Parametric and Non-Parametric Memories](https://mlsanity.com/paper/2212.10511/) (2022)
- [Domain-Specific Language Model Pretraining for Biomedical Natural Language Processing](https://mlsanity.com/paper/2007.15779/) (2020)
- [Publicly Available Clinical BERT Embeddings](https://mlsanity.com/paper/1904.03323/) (2019)
- [Gemma: Open Models Based on Gemini Research and Technology](https://mlsanity.com/paper/2403.08295/) (2024)
- [A Multitask, Multilingual, Multimodal Evaluation of ChatGPT on Reasoning, Hallucination, and Interactivity](https://mlsanity.com/paper/2302.04023/) (2023)
- [MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answering](https://mlsanity.com/paper/2203.14371/) (2022)
- [BioGPT: Generative Pre-trained Transformer for Biomedical Text Generation and Mining](https://mlsanity.com/paper/2210.10341/) (2022)

## Built on by (most cited first, 17 of 17)

- [Retrieval Augmented Generation (RAG) and Beyond: A Comprehensive Survey on How to Make your LLMs use External Data More Wisely](https://mlsanity.com/paper/2409.14924/) (2024)
- [A Survey on Medical Large Language Models: Technology, Application, Trustworthiness, and Future Directions](https://mlsanity.com/paper/2406.03712/) (2024)
- [The Sociolinguistic Foundations of Language Modeling](https://mlsanity.com/paper/2407.09241/) (2024)
- [The Road to Artificial SuperIntelligence: A Comprehensive Survey of Superalignment](https://mlsanity.com/paper/2412.16468/) (2024)
- [Adversarial Attacks on Large Language Models in Medicine](https://mlsanity.com/paper/2406.12259/) (2024)
- [MedGUIDE: Benchmarking Clinical Decision-Making in Large Language Models](https://mlsanity.com/paper/2505.11613/) (2025)
- [From Text to Multimodality: Exploring the Evolution and Impact of Large Language Models in Medical Practice](https://mlsanity.com/paper/2410.01812/) (2024)
- [MedOmni-45deg: A Safety-Performance Benchmark for Reasoning-Oriented LLMs in Medicine](https://mlsanity.com/paper/2508.16213/) (2025)
- [Memorization in Large Language Models in Medicine: Prevalence, Characteristics, and Implications](https://mlsanity.com/paper/2509.08604/) (2025)
- [TestAgent: Automatic Benchmarking and Exploratory Interaction for Evaluating LLMs in Vertical Domains](https://mlsanity.com/paper/2410.11507/) (2024)
- [A Proposed S.C.O.R.E. Evaluation Framework for Large Language Models : Safety, Consensus, Objectivity, Reproducibility and Explainability](https://mlsanity.com/paper/2407.07666/) (2024)
- [GAPS: A Clinically Grounded, Automated Benchmark for Evaluating AI Clinicians](https://mlsanity.com/paper/2510.13734/) (2025)
- [MedTutor: A Retrieval-Augmented LLM System for Case-Based Medical Education](https://mlsanity.com/paper/2601.06979/) (2026)
- [Q-FAKER: Query-free Hard Black-box Attack via Controlled Generation](https://mlsanity.com/paper/2504.13551/) (2025)
- [CMQCIC-Bench: A Chinese Benchmark for Evaluating Large Language Models in Medical Quality Control Indicator Calculation](https://mlsanity.com/paper/2502.11703/) (2025)
- [KRAL: Knowledge and Reasoning Augmented Learning for LLM-assisted Clinical Antimicrobial Therapy](https://mlsanity.com/paper/2511.15974/) (2025)
- [Trade-offs in Medical LLM Adaptation: An Empirical Study in French QA](https://mlsanity.com/paper/2606.19266/) (2026)

## Abstract (arXiv)

Since the inception of the Transformer architecture in 2017, Large Language Models (LLMs) such as GPT and BERT have evolved significantly, impacting various industries with their advanced capabilities in language understanding and generation. These models have shown potential to transform the medical field, highlighting the necessity for specialized evaluation frameworks to ensure their effective and ethical deployment. This comprehensive survey delineates the extensive application and requisite evaluation of LLMs within healthcare, emphasizing the critical need for empirical validation to fully exploit their capabilities in enhancing healthcare outcomes. Our survey is structured to provide an in-depth analysis of LLM applications across clinical settings, medical text data processing, research, education, and public health awareness. We begin by exploring the roles of LLMs in various medical applications, detailing their evaluation based on performance in tasks such as clinical diagnosis, medical text data processing, information retrieval, data analysis, and educational content generation. The subsequent sections offer a comprehensive discussion on the evaluation methods and metrics employed, including models, evaluators, and comparative experiments. We further examine the benchmarks and datasets utilized in these evaluations, providing a categorized description of benchmarks for tasks like question answering, summarization, information extraction, bioinformatics, information retrieval and general comprehensive benchmarks. This structure ensures a thorough understanding of how LLMs are assessed for their effectiveness, accuracy, usability, and ethical alignment in the medical domain. ...