# Multi-target and multi-stage liver lesion segmentation and detection in multi-phase computed tomography scans

arXiv: https://arxiv.org/abs/2404.11152 · HTML: https://mlsanity.com/paper/2404.11152/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 16 of its 39 references that are in the map.
- First posted on arXiv 17 Apr 2024.

## Builds on (most cited first, 16 of 16)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
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- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Microsoft COCO: Common Objects in Context](https://mlsanity.com/paper/1405.0312/) (2014)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [Fully Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1411.4038/) (2014)
- [SegNet: A Deep Convolutional Encoder-Decoder Architecture for Image Segmentation](https://mlsanity.com/paper/1511.00561/) (2015)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Images](https://mlsanity.com/paper/2201.01266/) (2022)
- [UNet++: Redesigning Skip Connections to Exploit Multiscale Features in Image Segmentation](https://mlsanity.com/paper/1912.05074/) (2019)
- [Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge](https://mlsanity.com/paper/1811.02629/) (2018)
- [The Liver Tumor Segmentation Benchmark (LiTS)](https://mlsanity.com/paper/1901.04056/) (2019)
- [DoubleU-Net: A Deep Convolutional Neural Network for Medical Image Segmentation](https://mlsanity.com/paper/2006.04868/) (2020)
- [A Comprehensive Study on Colorectal Polyp Segmentation with ResUNet++, Conditional Random Field and Test-Time Augmentation](https://mlsanity.com/paper/2107.12435/) (2021)
- [Deeply-Supervised CNN for Prostate Segmentation](https://mlsanity.com/paper/1703.07523/) (2017)
- [OctopusNet: A Deep Learning Segmentation Network for Multi-modal Medical Images](https://mlsanity.com/paper/1906.02031/) (2019)

## Abstract (arXiv)

Multi-phase computed tomography (CT) scans use contrast agents to highlight different anatomical structures within the body to improve the probability of identifying and detecting anatomical structures of interest and abnormalities such as liver lesions. Yet, detecting these lesions remains a challenging task as these lesions vary significantly in their size, shape, texture, and contrast with respect to surrounding tissue. Therefore, radiologists need to have an extensive experience to be able to identify and detect these lesions. Segmentation-based neural networks can assist radiologists with this task. Current state-of-the-art lesion segmentation networks use the encoder-decoder design paradigm based on the UNet architecture where the multi-phase CT scan volume is fed to the network as a multi-channel input. Although this approach utilizes information from all the phases and outperform single-phase segmentation networks, we demonstrate that their performance is not optimal and can be further improved by incorporating the learning from models trained on each single-phase individually. Our approach comprises three stages. The first stage identifies the regions within the liver where there might be lesions at three different scales (4, 8, and 16 mm). The second stage includes the main segmentation model trained using all the phases as well as a segmentation model trained on each of the phases individually. The third stage uses the multi-phase CT volumes together with the predictions from each of the segmentation models to generate the final segmentation map. Overall, our approach improves relative liver lesion segmentation performance by 1.6% while reducing performance variability across subjects by 8% when compared to the current state-of-the-art models.