# Prescribing the Right Remedy: Mitigating Hallucinations in Large Vision-Language Models via Targeted Instruction Tuning

arXiv: https://arxiv.org/abs/2404.10332 · HTML: https://mlsanity.com/paper/2404.10332/

## Key facts

- Cited by 6 papers in the map (data through 14 Oct 2026).
- Placed in Hallucination mitigation in LVLMs, one of 16 directions in Multimodal LLMs / vision-language models.
- Builds on 24 of its 28 references that are in the map.
- First posted on arXiv 16 Apr 2024.

## Placed in

- Multimodal LLMs / vision-language models / [Hallucination mitigation in LVLMs](https://mlsanity.com/mllm/hallucination-mitigation-in-lvlms/)

## Builds on (most cited first, 24 of 24)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Microsoft COCO: Common Objects in Context](https://mlsanity.com/paper/1405.0312/) (2014)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Visual Instruction Tuning](https://mlsanity.com/paper/2304.08485/) (2023)
- [BLIP-2: Bootstrapping Language-Image Pre-training with Frozen Image Encoders and Large Language Models](https://mlsanity.com/paper/2301.12597/) (2023)
- [Flamingo: a Visual Language Model for Few-Shot Learning](https://mlsanity.com/paper/2204.14198/) (2022)
- [Grounding DINO: Marrying DINO with Grounded Pre-Training for Open-Set Object Detection](https://mlsanity.com/paper/2303.05499/) (2023)
- [InstructBLIP: Towards General-purpose Vision-Language Models with Instruction Tuning](https://mlsanity.com/paper/2305.06500/) (2023)
- [MiniGPT-4: Enhancing Vision-Language Understanding with Advanced Large Language Models](https://mlsanity.com/paper/2304.10592/) (2023)
- [Evaluating Object Hallucination in Large Vision-Language Models](https://mlsanity.com/paper/2305.10355/) (2023)
- [mPLUG-Owl: Modularization Empowers Large Language Models with Multimodality](https://mlsanity.com/paper/2304.14178/) (2023)
- [Language Is Not All You Need: Aligning Perception with Language Models](https://mlsanity.com/paper/2302.14045/) (2023)
- [Mitigating Hallucination in Large Multi-Modal Models via Robust Instruction Tuning](https://mlsanity.com/paper/2306.14565/) (2023)
- [Analyzing and Mitigating Object Hallucination in Large Vision-Language Models](https://mlsanity.com/paper/2310.00754/) (2023)
- [Woodpecker: Hallucination Correction for Multimodal Large Language Models](https://mlsanity.com/paper/2310.16045/) (2023)
- [F-VLM: Open-Vocabulary Object Detection upon Frozen Vision and Language Models](https://mlsanity.com/paper/2209.15639/) (2022)
- [HalluciDoctor: Mitigating Hallucinatory Toxicity in Visual Instruction Data](https://mlsanity.com/paper/2311.13614/) (2023)
- [VIGC: Visual Instruction Generation and Correction](https://mlsanity.com/paper/2308.12714/) (2023)
- [CIEM: Contrastive Instruction Evaluation Method for Better Instruction Tuning](https://mlsanity.com/paper/2309.02301/) (2023)
- [Visual Hallucinations of Multi-modal Large Language Models](https://mlsanity.com/paper/2402.14683/) (2024)
- [Logical Closed Loop: Uncovering Object Hallucinations in Large Vision-Language Models](https://mlsanity.com/paper/2402.11622/) (2024)

## Built on by (most cited first, 6 of 6)

- [Don't Let the Video Speak: Audio-Contrastive Preference Optimization for Audio-Visual Language Models](https://mlsanity.com/paper/2604.14129/) (2026)
- [Empowering Multimodal LLMs with External Tools: A Comprehensive Survey](https://mlsanity.com/paper/2508.10955/) (2025)
- [Noise Augmented Fine Tuning for Mitigating Hallucinations in Large Language Models](https://mlsanity.com/paper/2504.03302/) (2025)
- [Mitigating hallucinations in healthcare LLMs with granular fact-checking and domain-specific adaptation](https://mlsanity.com/paper/2512.16189/) (2025)
- [System-Mediated Attention Imbalances Make Vision-Language Models Say Yes](https://mlsanity.com/paper/2601.12430/) (2026)
- [EviAnchor: Mitigating Hallucinations in Large Vision-Language Models via Regional Visual Evidence Compensation](https://mlsanity.com/paper/2608.29092/) (2026)

## Abstract (arXiv)

Despite achieving outstanding performance on various cross-modal tasks, current large vision-language models (LVLMs) still suffer from hallucination issues, manifesting as inconsistencies between their generated responses and the corresponding images. Prior research has implicated that the low quality of instruction data, particularly the skewed balance between positive and negative samples, is a significant contributor to model hallucinations. Recently, researchers have proposed high-quality instruction datasets, such as LRV-Instruction, to mitigate model hallucination. Nonetheless, our investigation reveals that hallucinatory concepts from different LVLMs exhibit specificity, i.e. the distribution of hallucinatory concepts varies significantly across models. Existing datasets did not consider the hallucination specificity of different models in the design processes, thereby diminishing their efficacy in mitigating model hallucination. In this paper, we propose a targeted instruction data generation framework named DFTG that tailored to the hallucination specificity of different models. Concretely, DFTG consists of two stages: hallucination diagnosis, which extracts the necessary information from the model's responses and images for hallucination diagnosis; and targeted data generation, which generates targeted instruction data based on diagnostic results. The experimental results on hallucination benchmarks demonstrate that the targeted instruction data generated by our method are more effective in mitigating hallucinations compared to previous datasets.