# MAProtoNet: A Multi-scale Attentive Interpretable Prototypical Part Network for 3D Magnetic Resonance Imaging Brain Tumor Classification

arXiv: https://arxiv.org/abs/2404.08917 · HTML: https://mlsanity.com/paper/2404.08917/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 39 of its 61 references that are in the map.
- First posted on arXiv 13 Apr 2024.

## Builds on (most cited first, 30 of 39)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Batch Normalization: Accelerating Deep Network Training by Reducing Internal Covariate Shift](https://mlsanity.com/paper/1502.03167/) (2015)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Squeeze-and-Excitation Networks](https://mlsanity.com/paper/1709.01507/) (2017)
- [Deformable DETR: Deformable Transformers for End-to-End Object Detection](https://mlsanity.com/paper/2010.04159/) (2020)
- [CBAM: Convolutional Block Attention Module](https://mlsanity.com/paper/1807.06521/) (2018)
- [Learning Deep Features for Discriminative Localization](https://mlsanity.com/paper/1512.04150/) (2015)
- [Masked-attention Mask Transformer for Universal Image Segmentation](https://mlsanity.com/paper/2112.01527/) (2021)
- [ImageNet-trained CNNs are biased towards texture; increasing shape bias improves accuracy and robustness](https://mlsanity.com/paper/1811.12231/) (2018)
- [Per-Pixel Classification is Not All You Need for Semantic Segmentation](https://mlsanity.com/paper/2107.06278/) (2021)
- [Concept Bottleneck Models](https://mlsanity.com/paper/2007.04612/) (2020)
- [This Looks Like That: Deep Learning for Interpretable Image Recognition](https://mlsanity.com/paper/1806.10574/) (2018)
- [Network Dissection: Quantifying Interpretability of Deep Visual Representations](https://mlsanity.com/paper/1704.05796/) (2017)
- [Image Segmentation Using Deep Learning: A Survey](https://mlsanity.com/paper/2001.05566/) (2020)
- [UNet 3+: A Full-Scale Connected UNet for Medical Image Segmentation](https://mlsanity.com/paper/2004.08790/) (2020)
- [Neural Prototype Trees for Interpretable Fine-grained Image Recognition](https://mlsanity.com/paper/2012.02046/) (2020)
- [TieNet: Text-Image Embedding Network for Common Thorax Disease Classification and Reporting in Chest X-rays](https://mlsanity.com/paper/1801.04334/) (2018)
- [Deformable ProtoPNet: An Interpretable Image Classifier Using Deformable Prototypes](https://mlsanity.com/paper/2111.15000/) (2021)
- [Smooth Grad-CAM++: An Enhanced Inference Level Visualization Technique for Deep Convolutional Neural Network Models](https://mlsanity.com/paper/1908.01224/) (2019)
- [Transparency of Deep Neural Networks for Medical Image Analysis: A Review of Interpretability Methods](https://mlsanity.com/paper/2111.02398/) (2021)
- [Rotate to Attend: Convolutional Triplet Attention Module](https://mlsanity.com/paper/2010.03045/) (2020)
- [XProtoNet: Diagnosis in Chest Radiography with Global and Local Explanations](https://mlsanity.com/paper/2103.10663/) (2021)
- [Robust and Interpretable Medical Image Classifiers via Concept Bottleneck Models](https://mlsanity.com/paper/2310.03182/) (2023)
- [ProtoSeg: Interpretable Semantic Segmentation with Prototypical Parts](https://mlsanity.com/paper/2301.12276/) (2023)
- [Explainable Deep Learning Methods in Medical Image Classification: A Survey](https://mlsanity.com/paper/2205.04766/) (2022)
- [Coherent Concept-based Explanations in Medical Image and Its Application to Skin Lesion Diagnosis](https://mlsanity.com/paper/2304.04579/) (2023)
- [SAUNet: Shape Attentive U-Net for Interpretable Medical Image Segmentation](https://mlsanity.com/paper/2001.07645/) (2020)

## Built on by (most cited first, 1 of 1)

- [ProtoPointNet: Prototype-Based Interpretable Classification of 3D Dental Point Clouds with Verifiable Spatial Activations](https://mlsanity.com/paper/2607.12335/) (2026)

## Abstract (arXiv)

Automated diagnosis with artificial intelligence has emerged as a promising area in the realm of medical imaging, while the interpretability of the introduced deep neural networks still remains an urgent concern. Although contemporary works, such as XProtoNet and MProtoNet, has sought to design interpretable prediction models for the issue, the localization precision of their resulting attribution maps can be further improved. To this end, we propose a Multi-scale Attentive Prototypical part Network, termed MAProtoNet, to provide more precise maps for attribution. Specifically, we introduce a concise multi-scale module to merge attentive features from quadruplet attention layers, and produces attribution maps. The proposed quadruplet attention layers can enhance the existing online class activation mapping loss via capturing interactions between the spatial and channel dimension, while the multi-scale module then fuses both fine-grained and coarse-grained information for precise maps generation. We also apply a novel multi-scale mapping loss for supervision on the proposed multi-scale module. Compared to existing interpretable prototypical part networks in medical imaging, MAProtoNet can achieve state-of-the-art performance in localization on brain tumor segmentation (BraTS) datasets, resulting in approximately 4% overall improvement on activation precision score (with a best score of 85.8%), without using additional annotated labels of segmentation. Our code will be released in https://github.com/TUAT-Novice/maprotonet.