# A Clinical-oriented Multi-level Contrastive Learning Method for Disease Diagnosis in Low-quality Medical Images

arXiv: https://arxiv.org/abs/2404.04887 · HTML: https://mlsanity.com/paper/2404.04887/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 15 of its 27 references that are in the map.
- First posted on arXiv 7 Apr 2024.

## Builds on (most cited first, 15 of 15)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases](https://mlsanity.com/paper/1705.02315/) (2017)
- [What Makes for Good Views for Contrastive Learning?](https://mlsanity.com/paper/2005.10243/) (2020)
- [Contrastive Learning with Hard Negative Samples](https://mlsanity.com/paper/2010.04592/) (2020)
- [CrossCLR: Cross-modal Contrastive Learning For Multi-modal Video Representations](https://mlsanity.com/paper/2109.14910/) (2021)
- [Evaluation of Retinal Image Quality Assessment Networks in Different Color-spaces](https://mlsanity.com/paper/1907.05345/) (2019)
- [Are all negatives created equal in contrastive instance discrimination?](https://mlsanity.com/paper/2010.06682/) (2020)
- [Self-supervised Feature Learning via Exploiting Multi-modal Data for Retinal Disease Diagnosis](https://mlsanity.com/paper/2007.11067/) (2020)
- [Semantic Redundancies in Image-Classification Datasets: The 10% You Don't Need](https://mlsanity.com/paper/1901.11409/) (2019)
- [Zoom-in-Net: Deep Mining Lesions for Diabetic Retinopathy Detection](https://mlsanity.com/paper/1706.04372/) (2017)
- [Lesion-based Contrastive Learning for Diabetic Retinopathy Grading from Fundus Images](https://mlsanity.com/paper/2107.08274/) (2021)
- [Structure-consistent Restoration Network for Cataract Fundus Image Enhancement](https://mlsanity.com/paper/2206.04684/) (2022)
- [Multi-Cell Multi-Task Convolutional Neural Networks for Diabetic Retinopathy Grading](https://mlsanity.com/paper/1808.10564/) (2018)

## Built on by (most cited first, 1 of 1)

- [Weakly Supervised Patch Annotation for Improved Screening of Diabetic Retinopathy](https://mlsanity.com/paper/2603.03991/) (2026)

## Abstract (arXiv)

Representation learning offers a conduit to elucidate distinctive features within the latent space and interpret the deep models. However, the randomness of lesion distribution and the complexity of low-quality factors in medical images pose great challenges for models to extract key lesion features. Disease diagnosis methods guided by contrastive learning (CL) have shown significant advantages in lesion feature representation. Nevertheless, the effectiveness of CL is highly dependent on the quality of the positive and negative sample pairs. In this work, we propose a clinical-oriented multi-level CL framework that aims to enhance the model's capacity to extract lesion features and discriminate between lesion and low-quality factors, thereby enabling more accurate disease diagnosis from low-quality medical images. Specifically, we first construct multi-level positive and negative pairs to enhance the model's comprehensive recognition capability of lesion features by integrating information from different levels and qualities of medical images. Moreover, to improve the quality of the learned lesion embeddings, we introduce a dynamic hard sample mining method based on self-paced learning. The proposed CL framework is validated on two public medical image datasets, EyeQ and Chest X-ray, demonstrating superior performance compared to other state-of-the-art disease diagnostic methods.