# Effective Lymph Nodes Detection in CT Scans Using Location Debiased Query Selection and Contrastive Query Representation in Transformer

arXiv: https://arxiv.org/abs/2404.03819 · HTML: https://mlsanity.com/paper/2404.03819/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 45 of its 74 references that are in the map.
- First posted on arXiv 4 Apr 2024.

## Builds on (most cited first, 30 of 45)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks](https://mlsanity.com/paper/1506.01497/) (2015)
- [Representation Learning with Contrastive Predictive Coding](https://mlsanity.com/paper/1807.03748/) (2018)
- [End-to-End Object Detection with Transformers](https://mlsanity.com/paper/2005.12872/) (2020)
- [Mask R-CNN](https://mlsanity.com/paper/1703.06870/) (2017)
- [Feature Pyramid Networks for Object Detection](https://mlsanity.com/paper/1612.03144/) (2016)
- [Fully Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1411.4038/) (2014)
- [Deformable DETR: Deformable Transformers for End-to-End Object Detection](https://mlsanity.com/paper/2010.04159/) (2020)
- [Supervised Contrastive Learning](https://mlsanity.com/paper/2004.11362/) (2020)
- [YOLOv3: An Incremental Improvement](https://mlsanity.com/paper/1804.02767/) (2018)
- [Masked-attention Mask Transformer for Universal Image Segmentation](https://mlsanity.com/paper/2112.01527/) (2021)
- [FCOS: Fully Convolutional One-Stage Object Detection](https://mlsanity.com/paper/1904.01355/) (2019)
- [YOLO9000: Better, Faster, Stronger](https://mlsanity.com/paper/1612.08242/) (2016)
- [DINO: DETR with Improved DeNoising Anchor Boxes for End-to-End Object Detection](https://mlsanity.com/paper/2203.03605/) (2022)
- [DAB-DETR: Dynamic Anchor Boxes are Better Queries for DETR](https://mlsanity.com/paper/2201.12329/) (2022)
- [DN-DETR: Accelerate DETR Training by Introducing Query DeNoising](https://mlsanity.com/paper/2203.01305/) (2022)
- [Conditional DETR for Fast Training Convergence](https://mlsanity.com/paper/2108.06152/) (2021)
- [Generalized Focal Loss: Learning Qualified and Distributed Bounding Boxes for Dense Object Detection](https://mlsanity.com/paper/2006.04388/) (2020)
- [Mask DINO: Towards A Unified Transformer-based Framework for Object Detection and Segmentation](https://mlsanity.com/paper/2206.02777/) (2022)
- [Transformers in Medical Imaging: A Survey](https://mlsanity.com/paper/2201.09873/) (2022)
- [VarifocalNet: An IoU-aware Dense Object Detector](https://mlsanity.com/paper/2008.13367/) (2020)
- [Acquisition of Localization Confidence for Accurate Object Detection](https://mlsanity.com/paper/1807.11590/) (2018)
- [DETRs with Hybrid Matching](https://mlsanity.com/paper/2207.13080/) (2022)
- [Efficient DETR: Improving End-to-End Object Detector with Dense Prior](https://mlsanity.com/paper/2104.01318/) (2021)
- [nnDetection: A Self-configuring Method for Medical Object Detection](https://mlsanity.com/paper/2106.00817/) (2021)
- [Rank-DETR for High Quality Object Detection](https://mlsanity.com/paper/2310.08854/) (2023)
- [Learning from Multiple Datasets with Heterogeneous and Partial Labels for Universal Lesion Detection in CT](https://mlsanity.com/paper/2009.02577/) (2020)
- [MULAN: Multitask Universal Lesion Analysis Network for Joint Lesion Detection, Tagging, and Segmentation](https://mlsanity.com/paper/1908.04373/) (2019)
- [MP-Former: Mask-Piloted Transformer for Image Segmentation](https://mlsanity.com/paper/2303.07336/) (2023)

## Built on by (most cited first, 3 of 3)

- [Dynamic Gradient Sparsification Training for Few-Shot Fine-tuning of CT Lymph Node Segmentation Foundation Model](https://mlsanity.com/paper/2503.00748/) (2025)
- [From Slices to Sequences: Autoregressive Tracking Transformer for Cohesive and Consistent 3D Lymph Node Detection in CT Scans](https://mlsanity.com/paper/2503.07933/) (2025)
- [QCell: Recombining and Aligning Cell Queries for Overlapping Instance Segmentation](https://mlsanity.com/paper/2608.29253/) (2026)

## Abstract (arXiv)

Lymph node (LN) assessment is a critical, indispensable yet very challenging task in the routine clinical workflow of radiology and oncology. Accurate LN analysis is essential for cancer diagnosis, staging, and treatment planning. Finding scatteredly distributed, low-contrast clinically relevant LNs in 3D CT is difficult even for experienced physicians under high inter-observer variations. Previous automatic LN detection works typically yield limited recall and high false positives (FPs) due to adjacent anatomies with similar image intensities, shapes, or textures (vessels, muscles, esophagus, etc). In this work, we propose a new LN DEtection TRansformer, named LN-DETR, to achieve more accurate performance. By enhancing the 2D backbone with a multi-scale 2.5D feature fusion to incorporate 3D context explicitly, more importantly, we make two main contributions to improve the representation quality of LN queries. 1) Considering that LN boundaries are often unclear, an IoU prediction head and a location debiased query selection are proposed to select LN queries of higher localization accuracy as the decoder query's initialization. 2) To reduce FPs, query contrastive learning is employed to explicitly reinforce LN queries towards their best-matched ground-truth queries over unmatched query predictions. Trained and tested on 3D CT scans of 1067 patients (with 10,000+ labeled LNs) via combining seven LN datasets from different body parts (neck, chest, and abdomen) and pathologies/cancers, our method significantly improves the performance of previous leading methods by > 4-5% average recall at the same FP rates in both internal and external testing. We further evaluate on the universal lesion detection task using NIH DeepLesion benchmark, and our method achieves the top performance of 88.46% averaged recall across 0.5 to 4 FPs per image, compared with other leading reported results.