# Mitigating analytical variability in fMRI results with style transfer

arXiv: https://arxiv.org/abs/2404.03703 · HTML: https://mlsanity.com/paper/2404.03703/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 30 of its 71 references that are in the map.
- First posted on arXiv 4 Apr 2024.

## Builds on (most cited first, 30 of 30)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Improved Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2102.09672/) (2021)
- [Improved Techniques for Training GANs](https://mlsanity.com/paper/1606.03498/) (2016)
- [Palette: Image-to-Image Diffusion Models](https://mlsanity.com/paper/2111.05826/) (2021)
- [StarGAN: Unified Generative Adversarial Networks for Multi-Domain Image-to-Image Translation](https://mlsanity.com/paper/1711.09020/) (2017)
- [ILVR: Conditioning Method for Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2108.02938/) (2021)
- [Unsupervised Image-to-Image Translation Networks](https://mlsanity.com/paper/1703.00848/) (2017)
- [Diffusion Autoencoders: Toward a Meaningful and Decodable Representation](https://mlsanity.com/paper/2111.15640/) (2021)
- [SRDiff: Single Image Super-Resolution with Diffusion Probabilistic Models](https://mlsanity.com/paper/2104.14951/) (2021)
- [Unsupervised Medical Image Translation with Adversarial Diffusion Models](https://mlsanity.com/paper/2207.08208/) (2022)
- [Low Dose CT Image Denoising Using a Generative Adversarial Network with Wasserstein Distance and Perceptual Loss](https://mlsanity.com/paper/1708.00961/) (2017)
- [MedGAN: Medical Image Translation using GANs](https://mlsanity.com/paper/1806.06397/) (2018)
- [UNIT-DDPM: UNpaired Image Translation with Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2104.05358/) (2021)
- [Deep MR to CT Synthesis using Unpaired Data](https://mlsanity.com/paper/1708.01155/) (2017)
- [Conditional Diffusion Models for Semantic 3D Brain MRI Synthesis](https://mlsanity.com/paper/2305.18453/) (2023)
- [Breaking the Dilemma of Medical Image-to-image Translation](https://mlsanity.com/paper/2110.06465/) (2021)
- [Conversion Between CT and MRI Images Using Diffusion and Score-Matching Models](https://mlsanity.com/paper/2209.12104/) (2022)
- [StainGAN: Stain Style Transfer for Digital Histological Images](https://mlsanity.com/paper/1804.01601/) (2018)
- [CoLa-Diff: Conditional Latent Diffusion Model for Multi-Modal MRI Synthesis](https://mlsanity.com/paper/2303.14081/) (2023)
- [Deep CT to MR Synthesis using Paired and Unpaired Data](https://mlsanity.com/paper/1805.10790/) (2018)
- [Cycle-guided Denoising Diffusion Probability Model for 3D Cross-modality MRI Synthesis](https://mlsanity.com/paper/2305.00042/) (2023)
- [MR-Contrast-Aware Image-to-Image Translations with Generative Adversarial Networks](https://mlsanity.com/paper/2104.01449/) (2021)
- [Uncovering communities of pipelines in the task-fMRI analytical space](https://mlsanity.com/paper/2312.06231/) (2023)
- [The HCP multi-pipeline dataset: an opportunity to investigate analytical variability in fMRI data analysis](https://mlsanity.com/paper/2312.14493/) (2023)
- [On the validity of fMRI studies with subject-level data processed through different pipelines](https://mlsanity.com/paper/2402.12900/) (2024)

## Abstract (arXiv)

We propose a novel approach to improve the reproducibility of neuroimaging results by converting statistic maps across different functional MRI pipelines. We make the assumption that pipelines used to compute fMRI statistic maps can be considered as a style component and we propose to use different generative models, among which, Generative Adversarial Networks (GAN) and Diffusion Models (DM) to convert statistic maps across different pipelines. We explore the performance of multiple GAN frameworks, and design a new DM framework for unsupervised multi-domain styletransfer. We constrain the generation of 3D fMRI statistic maps using the latent space of an auxiliary classifier that distinguishes statistic maps from different pipelines and extend traditional sampling techniques used in DM to improve the transition performance. Our experiments demonstrate that our proposed methods aresuccessful: pipelines can indeed be transferred as a style component, providing animportant source of data augmentation for future medical studies.