# Foundation Model for Advancing Healthcare: Challenges, Opportunities, and Future Directions

arXiv: https://arxiv.org/abs/2404.03264 · HTML: https://mlsanity.com/paper/2404.03264/

## Key facts

- Cited by 77 papers in the map (data through 14 Oct 2026).
- Builds on 158 of its 287 references that are in the map.
- First posted on arXiv 4 Apr 2024.

## Builds on (most cited first, 30 of 158)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Visual Instruction Tuning](https://mlsanity.com/paper/2304.08485/) (2023)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [Flamingo: a Visual Language Model for Few-Shot Learning](https://mlsanity.com/paper/2204.14198/) (2022)
- [Large Language Models are Zero-Shot Reasoners](https://mlsanity.com/paper/2205.11916/) (2022)
- [On the Opportunities and Risks of Foundation Models](https://mlsanity.com/paper/2108.07258/) (2021)
- [SimCSE: Simple Contrastive Learning of Sentence Embeddings](https://mlsanity.com/paper/2104.08821/) (2021)
- [PaLM-E: An Embodied Multimodal Language Model](https://mlsanity.com/paper/2303.03378/) (2023)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [Jailbroken: How Does LLM Safety Training Fail?](https://mlsanity.com/paper/2307.02483/) (2023)
- [SciBERT: A Pretrained Language Model for Scientific Text](https://mlsanity.com/paper/1903.10676/) (2019)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [CoCa: Contrastive Captioners are Image-Text Foundation Models](https://mlsanity.com/paper/2205.01917/) (2022)
- [SimMIM: A Simple Framework for Masked Image Modeling](https://mlsanity.com/paper/2111.09886/) (2021)
- [Publicly Available Clinical BERT Embeddings](https://mlsanity.com/paper/1904.03323/) (2019)
- [A Comprehensive Survey of Continual Learning: Theory, Method and Application](https://mlsanity.com/paper/2302.00487/) (2023)
- [Generalized Out-of-Distribution Detection: A Survey](https://mlsanity.com/paper/2110.11334/) (2021)

## Built on by (most cited first, 30 of 77)

- [Continual Learning of Large Language Models: A Comprehensive Survey](https://mlsanity.com/paper/2404.16789/) (2024)
- [Multimodal Chain-of-Thought Reasoning: A Comprehensive Survey](https://mlsanity.com/paper/2503.12605/) (2025)
- [MedSAM2: Segment Anything in 3D Medical Images and Videos](https://mlsanity.com/paper/2504.03600/) (2025)
- [A Comprehensive Survey of Foundation Models in Medicine](https://mlsanity.com/paper/2406.10729/) (2024)
- [Large-Scale 3D Medical Image Pre-training with Geometric Context Priors](https://mlsanity.com/paper/2410.09890/) (2024)
- [MIRA: Medical Time Series Foundation Model for Real-World Health Data](https://mlsanity.com/paper/2506.07584/) (2025)
- [MiM: Mask in Mask Self-Supervised Pre-Training for 3D Medical Image Analysis](https://mlsanity.com/paper/2404.15580/) (2024)
- [HiMAE: Hierarchical Masked Autoencoders Discover Resolution-Specific Structure in Wearable Time Series](https://mlsanity.com/paper/2510.25785/) (2025)
- [A Survey on Trustworthiness in Foundation Models for Medical Image Analysis](https://mlsanity.com/paper/2407.15851/) (2024)
- [A Survey on Large Language Models from General Purpose to Medical Applications: Datasets, Methodologies, and Evaluations](https://mlsanity.com/paper/2406.10303/) (2024)
- [Deep Learning and Foundation Models for Weather Prediction: A Survey](https://mlsanity.com/paper/2501.06907/) (2025)
- [Towards a vision foundation model for comprehensive assessment of Cardiac MRI](https://mlsanity.com/paper/2410.01665/) (2024)
- [EchoApex: A General-Purpose Vision Foundation Model for Echocardiography](https://mlsanity.com/paper/2410.11092/) (2024)
- [A Versatile Pathology Co-pilot via Reasoning Enhanced Multimodal Large Language Model](https://mlsanity.com/paper/2507.17303/) (2025)
- [Pathology Foundation Models](https://mlsanity.com/paper/2407.21317/) (2024)
- [MedConceptsQA: Open Source Medical Concepts QA Benchmark](https://mlsanity.com/paper/2405.07348/) (2024)
- [FoMoH: A clinically meaningful foundation model evaluation for structured electronic health records](https://mlsanity.com/paper/2505.16941/) (2025)
- [From large language models to multimodal AI: A scoping review on the potential of generative AI in medicine](https://mlsanity.com/paper/2502.09242/) (2025)
- [Generalist versus Specialist Vision Foundation Models for Ocular Disease and Oculomics](https://mlsanity.com/paper/2509.03421/) (2025)
- [Reinforcement Learning in the Real World: A Survey of Statistical Challenges and Future Directions](https://mlsanity.com/paper/2601.15353/) (2026)
- [QUB-Cirdan at "Discharge Me!": Zero shot discharge letter generation by open-source LLM](https://mlsanity.com/paper/2406.00041/) (2024)
- [Homeomorphism Prior for False Positive and Negative Problem in Medical Image Dense Contrastive Representation Learning](https://mlsanity.com/paper/2502.05282/) (2025)
- [Discovering Pathology Rationale and Token Allocation for Efficient Multimodal Pathology Reasoning](https://mlsanity.com/paper/2505.15687/) (2025)
- [Reflections from Research Roundtables at the Conference on Health, Inference, and Learning (CHIL) 2025](https://mlsanity.com/paper/2510.15217/) (2025)
- [Medical world models in healthcare: foundations, applications, and challenges for trustworthy clinical translation](https://mlsanity.com/paper/2607.25242/) (2026)
- [Advancing Precision Oncology Through Modeling of Longitudinal and Multimodal Data](https://mlsanity.com/paper/2502.07836/) (2025)
- [Vector Contrastive Learning For Pixel-Wise Pretraining In Medical Vision](https://mlsanity.com/paper/2506.20850/) (2025)
- [SingLEM: Single-Channel Large EEG Model](https://mlsanity.com/paper/2509.17920/) (2025)
- [Towards Generalist Intelligence in Dentistry: Vision Foundation Models for Oral and Maxillofacial Radiology](https://mlsanity.com/paper/2510.14532/) (2025)
- [Adaptation of Foundation Models for Medical Image Analysis: Strategies, Challenges, and Future Directions](https://mlsanity.com/paper/2511.01284/) (2025)

## Abstract (arXiv)

Foundation model, which is pre-trained on broad data and is able to adapt to a wide range of tasks, is advancing healthcare. It promotes the development of healthcare artificial intelligence (AI) models, breaking the contradiction between limited AI models and diverse healthcare practices. Much more widespread healthcare scenarios will benefit from the development of a healthcare foundation model (HFM), improving their advanced intelligent healthcare services. Despite the impending widespread deployment of HFMs, there is currently a lack of clear understanding about how they work in the healthcare field, their current challenges, and where they are headed in the future. To answer these questions, a comprehensive and deep survey of the challenges, opportunities, and future directions of HFMs is presented in this survey. It first conducted a comprehensive overview of the HFM including the methods, data, and applications for a quick grasp of the current progress. Then, it made an in-depth exploration of the challenges present in data, algorithms, and computing infrastructures for constructing and widespread application of foundation models in healthcare. This survey also identifies emerging and promising directions in this field for future development. We believe that this survey will enhance the community's comprehension of the current progress of HFM and serve as a valuable source of guidance for future development in this field. The latest HFM papers and related resources are maintained on our website: https://github.com/YutingHe-list/Awesome-Foundation-Models-for-Advancing-Healthcare.