# Localising the Seizure Onset Zone from Single-Pulse Electrical Stimulation Responses with a CNN Transformer

arXiv: https://arxiv.org/abs/2403.20324 · HTML: https://mlsanity.com/paper/2403.20324/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 12 of its 32 references that are in the map.
- First posted on arXiv 29 Mar 2024.

## Builds on (most cited first, 12 of 12)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [Neural Machine Translation by Jointly Learning to Align and Translate](https://mlsanity.com/paper/1409.0473/) (2014)
- [Axiomatic Attribution for Deep Networks](https://mlsanity.com/paper/1703.01365/) (2017)
- [Optuna: A Next-generation Hyperparameter Optimization Framework](https://mlsanity.com/paper/1907.10902/) (2019)
- [Decision Transformer: Reinforcement Learning via Sequence Modeling](https://mlsanity.com/paper/2106.01345/) (2021)
- [Temporal Fusion Transformers for Interpretable Multi-horizon Time Series Forecasting](https://mlsanity.com/paper/1912.09363/) (2019)
- [Multimodal Machine Learning in Precision Health](https://mlsanity.com/paper/2204.04777/) (2022)
- [Machine Learning Methods Applied to Cortico-Cortical Evoked Potentials Aid in Localizing Seizure Onset Zones](https://mlsanity.com/paper/2211.07867/) (2022)

## Abstract (arXiv)

Epilepsy is one of the most common neurological disorders, often requiring surgical intervention when medication fails to control seizures. For effective surgical outcomes, precise localisation of the epileptogenic focus - often approximated through the Seizure Onset Zone (SOZ) - is critical yet remains a challenge. Active probing through electrical stimulation is already standard clinical practice for identifying epileptogenic areas. Our study advances the application of deep learning for SOZ localisation using Single-Pulse Electrical Stimulation (SPES) responses, with two key contributions. Firstly, we implement an existing deep learning model to compare two SPES analysis paradigms: divergent and convergent. These paradigms evaluate outward and inward effective connections, respectively. We assess the generalisability of these models to unseen patients and electrode placements using held-out test sets. Our findings reveal a notable improvement in moving from a divergent (AUROC: 0.574) to a convergent approach (AUROC: 0.666), marking the first application of the latter in this context. Secondly, we demonstrate the efficacy of CNN Transformers with cross-channel attention in handling heterogeneous electrode placements, increasing the AUROC to 0.730. These findings represent a significant step in modelling patient-specific intracranial EEG electrode placements in SPES. Future work will explore integrating these models into clinical decision-making processes to bridge the gap between deep learning research and practical healthcare applications.