# Brain-Shift: Unsupervised Pseudo-Healthy Brain Synthesis for Novel Biomarker Extraction in Chronic Subdural Hematoma

arXiv: https://arxiv.org/abs/2403.19415 · HTML: https://mlsanity.com/paper/2403.19415/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 6 of its 28 references that are in the map.
- First posted on arXiv 28 Mar 2024.

## Builds on (most cited first, 6 of 6)

- [Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Images](https://mlsanity.com/paper/2201.01266/) (2022)
- [VoxelMorph: A Learning Framework for Deformable Medical Image Registration](https://mlsanity.com/paper/1809.05231/) (2018)
- [Unsupervised Learning of Probabilistic Diffeomorphic Registration for Images and Surfaces](https://mlsanity.com/paper/1903.03545/) (2019)
- [Evaluation of a Tree-based Pipeline Optimization Tool for Automating Data Science](https://mlsanity.com/paper/1603.06212/) (2016)
- [Learning Deep Embeddings with Histogram Loss](https://mlsanity.com/paper/1611.00822/) (2016)
- [Visual Feature Attribution using Wasserstein GANs](https://mlsanity.com/paper/1711.08998/) (2017)

## Abstract (arXiv)

Chronic subdural hematoma (cSDH) is a common neurological condition characterized by the accumulation of blood between the brain and the dura mater. This accumulation of blood can exert pressure on the brain, potentially leading to fatal outcomes. Treatment options for cSDH are limited to invasive surgery or non-invasive management. Traditionally, the midline shift, hand-measured by experts from an ideal sagittal plane, and the hematoma volume have been the primary metrics for quantifying and analyzing cSDH. However, these approaches do not quantify the local 3D brain deformation caused by cSDH. We propose a novel method using anatomy-aware unsupervised diffeomorphic pseudo-healthy synthesis to generate brain deformation fields. The deformation fields derived from this process are utilized to extract biomarkers that quantify the shift in the brain due to cSDH. We use CT scans of 121 patients for training and validation of our method and find that our metrics allow the identification of patients who require surgery. Our results indicate that automatically obtained brain deformation fields might contain prognostic value for personalized cSDH treatment. Our implementation is available on: github.com/Barisimre/brain-morphing