# Innovative Quantitative Analysis for Disease Progression Assessment in Familial Cerebral Cavernous Malformations

arXiv: https://arxiv.org/abs/2403.15803 · HTML: https://mlsanity.com/paper/2403.15803/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 21 of its 54 references that are in the map.
- First posted on arXiv 23 Mar 2024.

## Builds on (most cited first, 21 of 21)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [Fully Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1411.4038/) (2014)
- [MobileNets: Efficient Convolutional Neural Networks for Mobile Vision Applications](https://mlsanity.com/paper/1704.04861/) (2017)
- [Encoder-Decoder with Atrous Separable Convolution for Semantic Image Segmentation](https://mlsanity.com/paper/1802.02611/) (2018)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [Generalized Intersection over Union: A Metric and A Loss for Bounding Box Regression](https://mlsanity.com/paper/1902.09630/) (2019)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [Road Extraction by Deep Residual U-Net](https://mlsanity.com/paper/1711.10684/) (2017)
- [TransFuse: Fusing Transformers and CNNs for Medical Image Segmentation](https://mlsanity.com/paper/2102.08005/) (2021)
- [CE-Net: Context Encoder Network for 2D Medical Image Segmentation](https://mlsanity.com/paper/1903.02740/) (2019)
- [UNeXt: MLP-based Rapid Medical Image Segmentation Network](https://mlsanity.com/paper/2203.04967/) (2022)
- [Recurrent Residual Convolutional Neural Network based on U-Net (R2U-Net) for Medical Image Segmentation](https://mlsanity.com/paper/1802.06955/) (2018)
- [Generalist Vision Foundation Models for Medical Imaging: A Case Study of Segment Anything Model on Zero-Shot Medical Segmentation](https://mlsanity.com/paper/2304.12637/) (2023)
- [ReLayNet: Retinal Layer and Fluid Segmentation of Macular Optical Coherence Tomography using Fully Convolutional Network](https://mlsanity.com/paper/1704.02161/) (2017)
- [Optic Disc and Cup Segmentation Methods for Glaucoma Detection with Modification of U-Net Convolutional Neural Network](https://mlsanity.com/paper/1704.00979/) (2017)
- [Pathological OCT Retinal Layer Segmentation using Branch Residual U-shape Networks](https://mlsanity.com/paper/1707.04931/) (2017)

## Abstract (arXiv)

Familial cerebral cavernous malformation (FCCM) is a hereditary disorder characterized by abnormal vascular structures within the central nervous system. The FCCM lesions are often numerous and intricate, making quantitative analysis of the lesions a labor-intensive task. Consequently, clinicians face challenges in quantitatively assessing the severity of lesions and determining whether lesions have progressed. To alleviate this problem, we propose a quantitative statistical framework for FCCM, comprising an efficient annotation module, an FCCM lesion segmentation module, and an FCCM lesion quantitative statistics module. Our framework demonstrates precise segmentation of the FCCM lesion based on efficient data annotation, achieving a Dice coefficient of 93.22%. More importantly, we focus on quantitative statistics of lesions, which is combined with image registration to realize the quantitative comparison of lesions between different examinations of patients, and a visualization framework has been established for doctors to comprehensively compare and analyze lesions. The experimental results have demonstrated that our proposed framework not only obtains objective, accurate, and comprehensive quantitative statistical information, which provides a quantitative assessment method for disease progression and drug efficacy study, but also considerably reduces the manual measurement and statistical workload of lesions, assisting clinical decision-making for FCCM and accelerating progress in FCCM clinical research. This highlights the potential of practical application of the framework in FCCM clinical research and clinical decision-making. The codes are available at https://github.com/6zrg/Quantitative-Statistics-of-FCCM.