# WEEP: A method for spatial interpretation of weakly supervised CNN models in computational pathology

arXiv: https://arxiv.org/abs/2403.15238 · HTML: https://mlsanity.com/paper/2403.15238/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 10 of its 30 references that are in the map.
- First posted on arXiv 22 Mar 2024.

## Builds on (most cited first, 10 of 10)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Learning Deep Features for Discriminative Localization](https://mlsanity.com/paper/1512.04150/) (2015)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2106.00908/) (2021)
- [Explainable artificial intelligence (XAI) in deep learning-based medical image analysis](https://mlsanity.com/paper/2107.10912/) (2021)
- [Learn To Pay Attention](https://mlsanity.com/paper/1804.02391/) (2018)
- [An Aggregation of Aggregation Methods in Computational Pathology](https://mlsanity.com/paper/2211.01256/) (2022)
- [Deep Learning for Weakly-Supervised Object Detection and Object Localization: A Survey](https://mlsanity.com/paper/2105.12694/) (2021)
- [Forward and Backward Feature Selection for Query Performance Prediction](https://mlsanity.com/paper/1912.04107/) (2019)

## Built on by (most cited first, 1 of 1)

- [Beyond Attention Heatmaps: How to Get Better Explanations for Multiple Instance Learning Models in Histopathology](https://mlsanity.com/paper/2603.08328/) (2026)

## Abstract (arXiv)

Deep learning enables the modelling of high-resolution histopathology whole-slide images (WSI). Weakly supervised learning of tile-level data is typically applied for tasks where labels only exist on the patient or WSI level (e.g. patient outcomes or histological grading). In this context, there is a need for improved spatial interpretability of predictions from such models. We propose a novel method, Wsi rEgion sElection aPproach (WEEP), for model interpretation. It provides a principled yet straightforward way to establish the spatial area of WSI required for assigning a particular prediction label. We demonstrate WEEP on a binary classification task in the area of breast cancer computational pathology. WEEP is easy to implement, is directly connected to the model-based decision process, and offers information relevant to both research and diagnostic applications.