# Towards Efficient Information Fusion: Concentric Dual Fusion Attention Based Multiple Instance Learning for Whole Slide Images

arXiv: https://arxiv.org/abs/2403.14346 · HTML: https://mlsanity.com/paper/2403.14346/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 26 of its 46 references that are in the map.
- First posted on arXiv 21 Mar 2024.

## Builds on (most cited first, 26 of 26)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [Squeeze-and-Excitation Networks](https://mlsanity.com/paper/1709.01507/) (2017)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2106.00908/) (2021)
- [Dual-stream Multiple Instance Learning Network for Whole Slide Image Classification with Self-supervised Contrastive Learning](https://mlsanity.com/paper/2011.08939/) (2020)
- [Scaling Vision Transformers to Gigapixel Images via Hierarchical Self-Supervised Learning](https://mlsanity.com/paper/2206.02647/) (2022)
- [DTFD-MIL: Double-Tier Feature Distillation Multiple Instance Learning for Histopathology Whole Slide Image Classification](https://mlsanity.com/paper/2203.12081/) (2022)
- [Whole Slide Images based Cancer Survival Prediction using Attention Guided Deep Multiple Instance Learning Networks](https://mlsanity.com/paper/2009.11169/) (2020)
- [Deep neural network models for computational histopathology: A survey](https://mlsanity.com/paper/1912.12378/) (2019)
- [Patch-based Convolutional Neural Network for Whole Slide Tissue Image Classification](https://mlsanity.com/paper/1504.07947/) (2015)
- [Interventional Bag Multi-Instance Learning On Whole-Slide Pathological Images](https://mlsanity.com/paper/2303.06873/) (2023)
- [Multi-scale Domain-adversarial Multiple-instance CNN for Cancer Subtype Classification with Unannotated Histopathological Images](https://mlsanity.com/paper/2001.01599/) (2020)
- [Task-specific Fine-tuning via Variational Information Bottleneck for Weakly-supervised Pathology Whole Slide Image Classification](https://mlsanity.com/paper/2303.08446/) (2023)
- [Attention, please! A survey of Neural Attention Models in Deep Learning](https://mlsanity.com/paper/2103.16775/) (2021)
- [HookNet: multi-resolution convolutional neural networks for semantic segmentation in histopathology whole-slide images](https://mlsanity.com/paper/2006.12230/) (2020)
- [Self-Supervision Closes the Gap Between Weak and Strong Supervision in Histology](https://mlsanity.com/paper/2012.03583/) (2020)
- [Differentiable Zooming for Multiple Instance Learning on Whole-Slide Images](https://mlsanity.com/paper/2204.12454/) (2022)
- [Streaming convolutional neural networks for end-to-end learning with multi-megapixel images](https://mlsanity.com/paper/1911.04432/) (2019)
- [Self-supervised driven consistency training for annotation efficient histopathology image analysis](https://mlsanity.com/paper/2102.03897/) (2021)
- [Diagnose Like a Pathologist: Transformer-Enabled Hierarchical Attention-Guided Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2301.08125/) (2023)
- [Multi-scale fully convolutional neural networks for histopathology image segmentation: from nuclear aberrations to the global tissue architecture](https://mlsanity.com/paper/1909.10726/) (2019)
- [PDBL: Improving Histopathological Tissue Classification with Plug-and-Play Pyramidal Deep-Broad Learning](https://mlsanity.com/paper/2111.03063/) (2021)
- [Patient-level Microsatellite Stability Assessment from Whole Slide Images By Combining Momentum Contrast Learning and Group Patch Embeddings](https://mlsanity.com/paper/2208.10429/) (2022)
- [Multi-Scale Attention-based Multiple Instance Learning for Classification of Multi-Gigapixel Histology Images](https://mlsanity.com/paper/2209.03041/) (2022)

## Abstract (arXiv)

In the realm of digital pathology, multi-magnification Multiple Instance Learning (multi-mag MIL) has proven effective in leveraging the hierarchical structure of Whole Slide Images (WSIs) to reduce information loss and redundant data. However, current methods fall short in bridging the domain gap between pretrained models and medical imaging, and often fail to account for spatial relationships across different magnifications. Addressing these challenges, we introduce the Concentric Dual Fusion Attention-MIL (CDFA-MIL) framework,which innovatively combines point-to-area feature-colum attention and point-to-point concentric-row attention using concentric patch. This approach is designed to effectively fuse correlated information, enhancing feature representation and providing stronger correlation guidance for WSI analysis. CDFA-MIL distinguishes itself by offering a robust fusion strategy that leads to superior WSI recognition. Its application has demonstrated exceptional performance, significantly surpassing existing MIL methods in accuracy and F1 scores on prominent datasets like Camelyon16 and TCGA-NSCLC. Specifically, CDFA-MIL achieved an average accuracy and F1-score of 93.7% and 94.1% respectively on these datasets, marking a notable advancement over traditional MIL approaches.