# Improving Generalizability of Extracting Social Determinants of Health Using Large Language Models through Prompt-tuning

arXiv: https://arxiv.org/abs/2403.12374 · HTML: https://mlsanity.com/paper/2403.12374/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 18 of its 38 references that are in the map.
- First posted on arXiv 19 Mar 2024.

## Builds on (most cited first, 18 of 18)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [RoBERTa: A Robustly Optimized BERT Pretraining Approach](https://mlsanity.com/paper/1907.11692/) (2019)
- [On the Opportunities and Risks of Foundation Models](https://mlsanity.com/paper/2108.07258/) (2021)
- [ALBERT: A Lite BERT for Self-supervised Learning of Language Representations](https://mlsanity.com/paper/1909.11942/) (2019)
- [Pre-train, Prompt, and Predict: A Systematic Survey of Prompting Methods in Natural Language Processing](https://mlsanity.com/paper/2107.13586/) (2021)
- [Making Pre-trained Language Models Better Few-shot Learners](https://mlsanity.com/paper/2012.15723/) (2020)
- [GatorTron: A Large Clinical Language Model to Unlock Patient Information from Unstructured Electronic Health Records](https://mlsanity.com/paper/2203.03540/) (2022)
- [Zero-Shot Learning Through Cross-Modal Transfer](https://mlsanity.com/paper/1301.3666/) (2013)
- [A Study of Generative Large Language Model for Medical Research and Healthcare](https://mlsanity.com/paper/2305.13523/) (2023)
- [Enhancing Clinical Concept Extraction with Contextual Embeddings](https://mlsanity.com/paper/1902.08691/) (2019)
- [Model Tuning or Prompt Tuning? A Study of Large Language Models for Clinical Concept and Relation Extraction](https://mlsanity.com/paper/2310.06239/) (2023)
- [The 2022 n2c2/UW Shared Task on Extracting Social Determinants of Health](https://mlsanity.com/paper/2301.05571/) (2023)
- [Clinical Concept and Relation Extraction Using Prompt-based Machine Reading Comprehension](https://mlsanity.com/paper/2303.08262/) (2023)
- [Clinical Relation Extraction Using Transformer-based Models](https://mlsanity.com/paper/2107.08957/) (2021)
- [Relation extraction from clinical texts using domain invariant convolutional neural network](https://mlsanity.com/paper/1606.09370/) (2016)
- [SODA: A Natural Language Processing Package to Extract Social Determinants of Health for Cancer Studies](https://mlsanity.com/paper/2212.03000/) (2022)

## Abstract (arXiv)

The progress in natural language processing (NLP) using large language models (LLMs) has greatly improved patient information extraction from clinical narratives. However, most methods based on the fine-tuning strategy have limited transfer learning ability for cross-domain applications. This study proposed a novel approach that employs a soft prompt-based learning architecture, which introduces trainable prompts to guide LLMs toward desired outputs. We examined two types of LLM architectures, including encoder-only GatorTron and decoder-only GatorTronGPT, and evaluated their performance for the extraction of social determinants of health (SDoH) using a cross-institution dataset from the 2022 n2c2 challenge and a cross-disease dataset from the University of Florida (UF) Health. The results show that decoder-only LLMs with prompt tuning achieved better performance in cross-domain applications. GatorTronGPT achieved the best F1 scores for both datasets, outperforming traditional fine-tuned GatorTron by 8.9% and 21.8% in a cross-institution setting, and 5.5% and 14.5% in a cross-disease setting.