# MindEye2: Shared-Subject Models Enable fMRI-To-Image With 1 Hour of Data

arXiv: https://arxiv.org/abs/2403.11207 · HTML: https://mlsanity.com/paper/2403.11207/

## Key facts

- Cited by 109 papers in the map (data through 14 Oct 2026).
- Builds on 49 of its 97 references that are in the map.
- First posted on arXiv 17 Mar 2024.

## Builds on (most cited first, 30 of 49)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Microsoft COCO: Common Objects in Context](https://mlsanity.com/paper/1405.0312/) (2014)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [BLIP-2: Bootstrapping Language-Image Pre-training with Frozen Image Encoders and Large Language Models](https://mlsanity.com/paper/2301.12597/) (2023)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- [SDXL: Improving Latent Diffusion Models for High-Resolution Image Synthesis](https://mlsanity.com/paper/2307.01952/) (2023)
- [LAION-5B: An open large-scale dataset for training next generation image-text models](https://mlsanity.com/paper/2210.08402/) (2022)
- [Sigmoid Loss for Language Image Pre-Training](https://mlsanity.com/paper/2303.15343/) (2023)
- [Unsupervised Learning of Visual Features by Contrasting Cluster Assignments](https://mlsanity.com/paper/2006.09882/) (2020)
- [SDEdit: Guided Image Synthesis and Editing with Stochastic Differential Equations](https://mlsanity.com/paper/2108.01073/) (2021)
- [IP-Adapter: Text Compatible Image Prompt Adapter for Text-to-Image Diffusion Models](https://mlsanity.com/paper/2308.06721/) (2023)
- [ZeRO: Memory Optimizations Toward Training Trillion Parameter Models](https://mlsanity.com/paper/1910.02054/) (2019)
- [Making Monolingual Sentence Embeddings Multilingual using Knowledge Distillation](https://mlsanity.com/paper/2004.09813/) (2020)
- [LiT: Zero-Shot Transfer with Locked-image text Tuning](https://mlsanity.com/paper/2111.07991/) (2021)
- [Mind the Gap: Understanding the Modality Gap in Multi-modal Contrastive Representation Learning](https://mlsanity.com/paper/2203.02053/) (2022)
- [GIT: A Generative Image-to-text Transformer for Vision and Language](https://mlsanity.com/paper/2205.14100/) (2022)
- [Common Diffusion Noise Schedules and Sample Steps are Flawed](https://mlsanity.com/paper/2305.08891/) (2023)
- [What the DAAM: Interpreting Stable Diffusion Using Cross Attention](https://mlsanity.com/paper/2210.04885/) (2022)
- [Versatile Diffusion: Text, Images and Variations All in One Diffusion Model](https://mlsanity.com/paper/2211.08332/) (2022)
- [Reconstructing the Mind's Eye: fMRI-to-Image with Contrastive Learning and Diffusion Priors](https://mlsanity.com/paper/2305.18274/) (2023)
- [Seeing Beyond the Brain: Conditional Diffusion Model with Sparse Masked Modeling for Vision Decoding](https://mlsanity.com/paper/2211.06956/) (2022)
- [Getting aligned on representational alignment](https://mlsanity.com/paper/2310.13018/) (2023)
- [VICRegL: Self-Supervised Learning of Local Visual Features](https://mlsanity.com/paper/2210.01571/) (2022)
- [Learnable latent embeddings for joint behavioral and neural analysis](https://mlsanity.com/paper/2204.00673/) (2022)
- [Mind Reader: Reconstructing complex images from brain activities](https://mlsanity.com/paper/2210.01769/) (2022)
- [From voxels to pixels and back: Self-supervision in natural-image reconstruction from fMRI](https://mlsanity.com/paper/1907.02431/) (2019)
- [Brain decoding: toward real-time reconstruction of visual perception](https://mlsanity.com/paper/2310.19812/) (2023)
- [MixCo: Mix-up Contrastive Learning for Visual Representation](https://mlsanity.com/paper/2010.06300/) (2020)

## Built on by (most cited first, 30 of 109)

- [NeuroPictor: Refining fMRI-to-Image Reconstruction via Multi-individual Pretraining and Multi-level Modulation](https://mlsanity.com/paper/2403.18211/) (2024)
- [MindTuner: Cross-Subject Visual Decoding with Visual Fingerprint and Semantic Correction](https://mlsanity.com/paper/2404.12630/) (2024)
- [Bridging the Vision-Brain Gap with an Uncertainty-Aware Blur Prior](https://mlsanity.com/paper/2503.04207/) (2025)
- [NeuroClips: Towards High-fidelity and Smooth fMRI-to-Video Reconstruction](https://mlsanity.com/paper/2410.19452/) (2024)
- [Neuro-3D: Towards 3D Visual Decoding from EEG Signals](https://mlsanity.com/paper/2411.12248/) (2024)
- [Scaling laws for decoding images from brain activity](https://mlsanity.com/paper/2501.15322/) (2025)
- [The Wisdom of a Crowd of Brains: A Universal Brain Encoder](https://mlsanity.com/paper/2406.12179/) (2024)
- [MindSimulator: Exploring Brain Concept Localization via Synthetic FMRI](https://mlsanity.com/paper/2503.02351/) (2025)
- [Towards a general-purpose foundation model for fMRI analysis](https://mlsanity.com/paper/2506.11167/) (2025)
- [MindLLM: A Subject-Agnostic and Versatile Model for fMRI-to-Text Decoding](https://mlsanity.com/paper/2502.15786/) (2025)
- [NeuroBridge: Bio-Inspired Self-Supervised EEG-to-Image Decoding via Cognitive Priors and Bidirectional Semantic Alignment](https://mlsanity.com/paper/2511.06836/) (2025)
- [Brain Mapping with Dense Features: Grounding Cortical Semantic Selectivity in Natural Images With Vision Transformers](https://mlsanity.com/paper/2410.05266/) (2024)
- [A foundation model of vision, audition, and language for in-silico neuroscience](https://mlsanity.com/paper/2605.04326/) (2026)
- [Mind's Eye: Image Recognition by EEG via Multimodal Similarity-Keeping Contrastive Learning](https://mlsanity.com/paper/2406.16910/) (2024)
- [CineBrain: A Large-Scale Multi-Modal Brain Dataset During Naturalistic Audiovisual Narrative Processing](https://mlsanity.com/paper/2503.06940/) (2025)
- [BrainGuard: Privacy-Preserving Multisubject Image Reconstructions from Brain Activities](https://mlsanity.com/paper/2501.14309/) (2025)
- [SynBrain: Enhancing Visual-to-fMRI Synthesis via Probabilistic Representation Learning](https://mlsanity.com/paper/2508.10298/) (2025)
- [NSD-Imagery: A benchmark dataset for extending fMRI vision decoding methods to mental imagery](https://mlsanity.com/paper/2506.06898/) (2025)
- [Toward Generalizing Visual Brain Decoding to Unseen Subjects](https://mlsanity.com/paper/2410.14445/) (2024)
- [Quantum-Brain: Quantum-Inspired Neural Network Approach to Vision-Brain Understanding](https://mlsanity.com/paper/2411.13378/) (2024)
- [Human-Aligned Image Models Improve Visual Decoding from the Brain](https://mlsanity.com/paper/2502.03081/) (2025)
- [A Survey on fMRI-based Brain Decoding for Reconstructing Multimodal Stimuli](https://mlsanity.com/paper/2503.15978/) (2025)
- [MoRE-Brain: Routed Mixture of Experts for Interpretable and Generalizable Cross-Subject fMRI Visual Decoding](https://mlsanity.com/paper/2505.15946/) (2025)
- [ZEBRA: Towards Zero-Shot Cross-Subject Generalization for Universal Brain Visual Decoding](https://mlsanity.com/paper/2510.27128/) (2025)
- [A Survey of fMRI to Image Reconstruction](https://mlsanity.com/paper/2502.16861/) (2025)
- [Neurons: Emulating the Human Visual Cortex Improves Fidelity and Interpretability in fMRI-to-Video Reconstruction](https://mlsanity.com/paper/2503.11167/) (2025)
- [FlexiBrain: Resolution-Agnostic Voxel-Level Encoding for Native fMRI](https://mlsanity.com/paper/2606.11500/) (2026)
- [Reanimating Images using Neural Representations of Dynamic Stimuli](https://mlsanity.com/paper/2406.02659/) (2024)
- [Dynadiff: Single-stage Decoding of Images from Continuously Evolving fMRI](https://mlsanity.com/paper/2505.14556/) (2025)
- [Scaling Vision Transformers for Functional MRI with Flat Maps](https://mlsanity.com/paper/2510.13768/) (2025)

## Abstract (arXiv)

Reconstructions of visual perception from brain activity have improved tremendously, but the practical utility of such methods has been limited. This is because such models are trained independently per subject where each subject requires dozens of hours of expensive fMRI training data to attain high-quality results. The present work showcases high-quality reconstructions using only 1 hour of fMRI training data. We pretrain our model across 7 subjects and then fine-tune on minimal data from a new subject. Our novel functional alignment procedure linearly maps all brain data to a shared-subject latent space, followed by a shared non-linear mapping to CLIP image space. We then map from CLIP space to pixel space by fine-tuning Stable Diffusion XL to accept CLIP latents as inputs instead of text. This approach improves out-of-subject generalization with limited training data and also attains state-of-the-art image retrieval and reconstruction metrics compared to single-subject approaches. MindEye2 demonstrates how accurate reconstructions of perception are possible from a single visit to the MRI facility. All code is available on GitHub.