# Interpretable Machine Learning for Survival Analysis

arXiv: https://arxiv.org/abs/2403.10250 · HTML: https://mlsanity.com/paper/2403.10250/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Builds on 53 of its 124 references that are in the map.
- First posted on arXiv 15 Mar 2024.

## Builds on (most cited first, 30 of 53)

- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- ["Why Should I Trust You?": Explaining the Predictions of Any Classifier](https://mlsanity.com/paper/1602.04938/) (2016)
- [Axiomatic Attribution for Deep Networks](https://mlsanity.com/paper/1703.01365/) (2017)
- [Deep Inside Convolutional Networks: Visualising Image Classification Models and Saliency Maps](https://mlsanity.com/paper/1312.6034/) (2013)
- [Learning Important Features Through Propagating Activation Differences](https://mlsanity.com/paper/1704.02685/) (2017)
- [Interpretability Beyond Feature Attribution: Quantitative Testing with Concept Activation Vectors (TCAV)](https://mlsanity.com/paper/1711.11279/) (2017)
- [SmoothGrad: removing noise by adding noise](https://mlsanity.com/paper/1706.03825/) (2017)
- [Counterfactual Explanations without Opening the Black Box: Automated Decisions and the GDPR](https://mlsanity.com/paper/1711.00399/) (2017)
- [Striving for Simplicity: The All Convolutional Net](https://mlsanity.com/paper/1412.6806/) (2014)
- [Network Dissection: Quantifying Interpretability of Deep Visual Representations](https://mlsanity.com/paper/1704.05796/) (2017)
- [Distribution-Free Predictive Inference For Regression](https://mlsanity.com/paper/1604.04173/) (2016)
- [Interpretable Explanations of Black Boxes by Meaningful Perturbation](https://mlsanity.com/paper/1704.03296/) (2017)
- [Fooling LIME and SHAP: Adversarial Attacks on Post hoc Explanation Methods](https://mlsanity.com/paper/1911.02508/) (2019)
- [All Models are Wrong, but Many are Useful: Learning a Variable's Importance by Studying an Entire Class of Prediction Models Simultaneously](https://mlsanity.com/paper/1801.01489/) (2018)
- [DeepSurv: Personalized Treatment Recommender System Using A Cox Proportional Hazards Deep Neural Network](https://mlsanity.com/paper/1606.00931/) (2016)
- [Neural Additive Models: Interpretable Machine Learning with Neural Nets](https://mlsanity.com/paper/2004.13912/) (2020)
- [Visualizing the Effects of Predictor Variables in Black Box Supervised Learning Models](https://mlsanity.com/paper/1612.08468/) (2016)
- [Explaining individual predictions when features are dependent: More accurate approximations to Shapley values](https://mlsanity.com/paper/1903.10464/) (2019)
- [ranger: A Fast Implementation of Random Forests for High Dimensional Data in C++ and R](https://mlsanity.com/paper/1508.04409/) (2015)
- [Multi-Objective Counterfactual Explanations](https://mlsanity.com/paper/2004.11165/) (2020)
- [Interpretable Machine Learning -- A Brief History, State-of-the-Art and Challenges](https://mlsanity.com/paper/2010.09337/) (2020)
- [Machine Learning for Survival Analysis: A Survey](https://mlsanity.com/paper/1708.04649/) (2017)
- [Unrestricted Permutation forces Extrapolation: Variable Importance Requires at least One More Model, or There Is No Free Variable Importance](https://mlsanity.com/paper/1905.03151/) (2019)
- [General Pitfalls of Model-Agnostic Interpretation Methods for Machine Learning Models](https://mlsanity.com/paper/2007.04131/) (2020)
- [Deep Learning for Survival Analysis: A Review](https://mlsanity.com/paper/2305.14961/) (2023)
- [Faith-Shap: The Faithful Shapley Interaction Index](https://mlsanity.com/paper/2203.00870/) (2022)
- [S-LIME: Stabilized-LIME for Model Explanation](https://mlsanity.com/paper/2106.07875/) (2021)
- [SurvTRACE: Transformers for Survival Analysis with Competing Events](https://mlsanity.com/paper/2110.00855/) (2021)
- [SurvLIME: A method for explaining machine learning survival models](https://mlsanity.com/paper/2003.08371/) (2020)

## Built on by (most cited first, 4 of 4)

- [CoxKAN: Kolmogorov-Arnold Networks for Interpretable, High-Performance Survival Analysis](https://mlsanity.com/paper/2409.04290/) (2024)
- [Gradient-based Explanations for Deep Learning Survival Models](https://mlsanity.com/paper/2502.04970/) (2025)
- [DNAMite: Interpretable Calibrated Survival Analysis with Discretized Additive Models](https://mlsanity.com/paper/2411.05923/) (2024)
- [Automated and Interpretable Survival Analysis from Multimodal Data](https://mlsanity.com/paper/2509.21600/) (2025)

## Abstract (arXiv)

With the spread and rapid advancement of black box machine learning models, the field of interpretable machine learning (IML) or explainable artificial intelligence (XAI) has become increasingly important over the last decade. This is particularly relevant for survival analysis, where the adoption of IML techniques promotes transparency, accountability and fairness in sensitive areas, such as clinical decision making processes, the development of targeted therapies, interventions or in other medical or healthcare related contexts. More specifically, explainability can uncover a survival model's potential biases and limitations and provide more mathematically sound ways to understand how and which features are influential for prediction or constitute risk factors. However, the lack of readily available IML methods may have deterred medical practitioners and policy makers in public health from leveraging the full potential of machine learning for predicting time-to-event data. We present a comprehensive review of the limited existing amount of work on IML methods for survival analysis within the context of the general IML taxonomy. In addition, we formally detail how commonly used IML methods, such as such as individual conditional expectation (ICE), partial dependence plots (PDP), accumulated local effects (ALE), different feature importance measures or Friedman's H-interaction statistics can be adapted to survival outcomes. An application of several IML methods to real data on data on under-5 year mortality of Ghanaian children from the Demographic and Health Surveys (DHS) Program serves as a tutorial or guide for researchers, on how to utilize the techniques in practice to facilitate understanding of model decisions or predictions.