# COMPRER: A Multimodal Multi-Objective Pretraining Framework for Enhanced Medical Image Representation

arXiv: https://arxiv.org/abs/2403.09672 · HTML: https://mlsanity.com/paper/2403.09672/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 15 of its 39 references that are in the map.
- First posted on arXiv 4 Feb 2024.

## Builds on (most cited first, 15 of 15)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
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- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [Bootstrap your own latent: A new approach to self-supervised Learning](https://mlsanity.com/paper/2006.07733/) (2020)
- [Zero-Shot Text-to-Image Generation](https://mlsanity.com/paper/2102.12092/) (2021)
- [On the Opportunities and Risks of Foundation Models](https://mlsanity.com/paper/2108.07258/) (2021)
- [Transformer Interpretability Beyond Attention Visualization](https://mlsanity.com/paper/2012.09838/) (2020)
- [Multi-Task Learning with Deep Neural Networks: A Survey](https://mlsanity.com/paper/2009.09796/) (2020)
- [Self-supervised Learning is More Robust to Dataset Imbalance](https://mlsanity.com/paper/2110.05025/) (2021)
- [Predicting Cardiovascular Risk Factors from Retinal Fundus Photographs using Deep Learning](https://mlsanity.com/paper/1708.09843/) (2017)

## Abstract (arXiv)

Substantial advances in multi-modal Artificial Intelligence (AI) facilitate the combination of diverse medical modalities to achieve holistic health assessments. We present COMPRER , a novel multi-modal, multi-objective pretraining framework which enhances medical-image representation, diagnostic inferences, and prognosis of diseases. COMPRER employs a multi-objective training framework, where each objective introduces distinct knowledge to the model. This includes a multimodal loss that consolidates information across different imaging modalities; A temporal loss that imparts the ability to discern patterns over time; Medical-measure prediction adds appropriate medical insights; Lastly, reconstruction loss ensures the integrity of image structure within the latent space. Despite the concern that multiple objectives could weaken task performance, our findings show that this combination actually boosts outcomes on certain tasks. Here, we apply this framework to both fundus images and carotid ultrasound, and validate our downstream tasks capabilities by predicting both current and future cardiovascular conditions. COMPRER achieved higher Area Under the Curve (AUC) scores in evaluating medical conditions compared to existing models on held-out data. On the Out-of-distribution (OOD) UK-Biobank dataset COMPRER maintains favorable performance over well-established models with more parameters, even though these models were trained on 75× more data than COMPRER. In addition, to better assess our model's performance in contrastive learning, we introduce a novel evaluation metric, providing deeper understanding of the effectiveness of the latent space pairing.