# Region-based U-net for accelerated training and enhanced precision in deep brain segmentation

arXiv: https://arxiv.org/abs/2403.09414 · HTML: https://mlsanity.com/paper/2403.09414/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 6 of its 21 references that are in the map.
- First posted on arXiv 14 Mar 2024.

## Builds on (most cited first, 6 of 6)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [Multi-Atlas Segmentation of Biomedical Images: A Survey](https://mlsanity.com/paper/1412.3421/) (2014)
- [3D Whole Brain Segmentation using Spatially Localized Atlas Network Tiles](https://mlsanity.com/paper/1903.12152/) (2019)
- [Evaluating the Impact of Intensity Normalization on MR Image Synthesis](https://mlsanity.com/paper/1812.04652/) (2018)
- [Automated brainstem parcellation using multi-atlas segmentation and deep neural network](https://mlsanity.com/paper/2102.03281/) (2021)

## Abstract (arXiv)

Segmentation of brain structures on MRI is the primary step for further quantitative analysis of brain diseases. Manual segmentation is still considered the gold standard in terms of accuracy; however, such data is extremely time-consuming to generate. This paper presents a deep learning-based segmentation approach for 12 deep-brain structures, utilizing multiple region-based U-Nets. The brain is divided into three focal regions of interest that encompass the brainstem, the ventricular system, and the striatum. Next, three region-based U-nets are run in parallel to parcellate these larger structures into their respective four substructures. This approach not only greatly reduces the training and processing times but also significantly enhances the segmentation accuracy, compared to segmenting the entire MRI image at once. Our approach achieves remarkable accuracy with an average Dice Similarity Coefficient (DSC) of 0.901 and 95% Hausdorff Distance (HD95) of 1.155 mm. The method was compared with state-of-the-art segmentation approaches, demonstrating a high level of accuracy and robustness of the proposed method.