# APPLE: Adversarial Privacy-aware Perturbations on Latent Embedding for Unfairness Mitigation

arXiv: https://arxiv.org/abs/2403.05114 · HTML: https://mlsanity.com/paper/2403.05114/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 24 of its 36 references that are in the map.
- First posted on arXiv 8 Mar 2024.

## Builds on (most cited first, 24 of 24)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [Equality of Opportunity in Supervised Learning](https://mlsanity.com/paper/1610.02413/) (2016)
- [Skin Lesion Analysis Toward Melanoma Detection 2018: A Challenge Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1902.03368/) (2019)
- [Generating Adversarial Examples with Adversarial Networks](https://mlsanity.com/paper/1801.02610/) (2018)
- [Learning Not to Learn: Training Deep Neural Networks with Biased Data](https://mlsanity.com/paper/1812.10352/) (2018)
- [A review of deep learning in medical imaging: Imaging traits, technology trends, case studies with progress highlights, and future promises](https://mlsanity.com/paper/2008.09104/) (2020)
- [FairPrune: Achieving Fairness Through Pruning for Dermatological Disease Diagnosis](https://mlsanity.com/paper/2203.02110/) (2022)
- [Fairness in Cardiac MR Image Analysis: An Investigation of Bias Due to Data Imbalance in Deep Learning Based Segmentation](https://mlsanity.com/paper/2106.12387/) (2021)
- [Improving the Fairness of Chest X-ray Classifiers](https://mlsanity.com/paper/2203.12609/) (2022)
- [Fairness-aware Adversarial Perturbation Towards Bias Mitigation for Deployed Deep Models](https://mlsanity.com/paper/2203.01584/) (2022)
- [Debiasing Skin Lesion Datasets and Models? Not So Fast](https://mlsanity.com/paper/2004.11457/) (2020)
- [CARZero: Cross-Attention Alignment for Radiology Zero-Shot Classification](https://mlsanity.com/paper/2402.17417/) (2024)
- [CMU-Net: A Strong ConvMixer-based Medical Ultrasound Image Segmentation Network](https://mlsanity.com/paper/2210.13012/) (2022)
- [Addressing Fairness Issues in Deep Learning-Based Medical Image Analysis: A Systematic Review](https://mlsanity.com/paper/2209.13177/) (2022)
- [Feature robustness and sex differences in medical imaging: a case study in MRI-based Alzheimer's disease detection](https://mlsanity.com/paper/2204.01737/) (2022)
- [FairAdaBN: Mitigating unfairness with adaptive batch normalization and its application to dermatological disease classification](https://mlsanity.com/paper/2303.08325/) (2023)
- [CIRCLe: Color Invariant Representation Learning for Unbiased Classification of Skin Lesions](https://mlsanity.com/paper/2208.13528/) (2022)
- [On Fairness of Medical Image Classification with Multiple Sensitive Attributes via Learning Orthogonal Representations](https://mlsanity.com/paper/2301.01481/) (2023)
- [A Study of Demographic Bias in CNN-based Brain MR Segmentation](https://mlsanity.com/paper/2208.06613/) (2022)
- [Improving Fairness in Image Classification via Sketching](https://mlsanity.com/paper/2211.00168/) (2022)
- [An investigation into the impact of deep learning model choice on sex and race bias in cardiac MR segmentation](https://mlsanity.com/paper/2308.13415/) (2023)
- [Slide-SAM: Medical SAM Meets Sliding Window](https://mlsanity.com/paper/2311.10121/) (2023)
- [Unveiling Fairness Biases in Deep Learning-Based Brain MRI Reconstruction](https://mlsanity.com/paper/2309.14392/) (2023)

## Built on by (most cited first, 2 of 2)

- [FairMedFM: Fairness Benchmarking for Medical Imaging Foundation Models](https://mlsanity.com/paper/2407.00983/) (2024)
- [FedSKD: Aggregation-free Model-heterogeneous Federated Learning via Multi-dimensional Similarity Knowledge Distillation for Medical Image Classification](https://mlsanity.com/paper/2503.18981/) (2025)

## Abstract (arXiv)

Ensuring fairness in deep-learning-based segmentors is crucial for health equity. Much effort has been dedicated to mitigating unfairness in the training datasets or procedures. However, with the increasing prevalence of foundation models in medical image analysis, it is hard to train fair models from scratch while preserving utility. In this paper, we propose a novel method, Adversarial Privacy-aware Perturbations on Latent Embedding (APPLE), that can improve the fairness of deployed segmentors by introducing a small latent feature perturber without updating the weights of the original model. By adding perturbation to the latent vector, APPLE decorates the latent vector of segmentors such that no fairness-related features can be passed to the decoder of the segmentors while preserving the architecture and parameters of the segmentor. Experiments on two segmentation datasets and five segmentors (three U-Net-like and two SAM-like) illustrate the effectiveness of our proposed method compared to several unfairness mitigation methods.