# IsolateGPT: An Execution Isolation Architecture for LLM-Based Agentic Systems

arXiv: https://arxiv.org/abs/2403.04960 · HTML: https://mlsanity.com/paper/2403.04960/

## Key facts

- Cited by 130 papers in the map (data through 14 Oct 2026).
- Placed in Agent threats, guardrails and governance, one of 16 directions in LLM agents and tool use.
- Builds on 15 of its 75 references that are in the map.
- First posted on arXiv 8 Mar 2024.

## Placed in

- LLM agents and tool use / [Agent threats, guardrails and governance](https://mlsanity.com/agents/agent-threats-guardrails-and-governance/)

## Builds on (most cited first, 15 of 15)

- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Efficient Memory Management for Large Language Model Serving with PagedAttention](https://mlsanity.com/paper/2309.06180/) (2023)
- [A Survey on Large Language Model based Autonomous Agents](https://mlsanity.com/paper/2308.11432/) (2023)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [Not what you've signed up for: Compromising Real-World LLM-Integrated Applications with Indirect Prompt Injection](https://mlsanity.com/paper/2302.12173/) (2023)
- [The Rise and Potential of Large Language Model Based Agents: A Survey](https://mlsanity.com/paper/2309.07864/) (2023)
- [MemGPT: Towards LLMs as Operating Systems](https://mlsanity.com/paper/2310.08560/) (2023)
- [Gorilla: Large Language Model Connected with Massive APIs](https://mlsanity.com/paper/2305.15334/) (2023)
- [InjecAgent: Benchmarking Indirect Prompt Injections in Tool-Integrated Large Language Model Agents](https://mlsanity.com/paper/2403.02691/) (2024)
- [Cognitive Architectures for Language Agents](https://mlsanity.com/paper/2309.02427/) (2023)
- [From Prompt Injections to SQL Injection Attacks: How Protected is Your LLM-Integrated Web Application?](https://mlsanity.com/paper/2308.01990/) (2023)
- [LLM Platform Security: Applying a Systematic Evaluation Framework to OpenAI's ChatGPT Plugins](https://mlsanity.com/paper/2309.10254/) (2023)
- [Demystifying RCE Vulnerabilities in LLM-Integrated Apps](https://mlsanity.com/paper/2309.02926/) (2023)
- [Fingerprinting the Fingerprinters: Learning to Detect Browser Fingerprinting Behaviors](https://mlsanity.com/paper/2008.04480/) (2020)

## Built on by (most cited first, 30 of 130)

- [Defeating Prompt Injections by Design](https://mlsanity.com/paper/2503.18813/) (2025)
- [From Persona to Personalization: A Survey on Role-Playing Language Agents](https://mlsanity.com/paper/2404.18231/) (2024)
- [System-Level Defense against Indirect Prompt Injection Attacks: An Information Flow Control Perspective](https://mlsanity.com/paper/2409.19091/) (2024)
- [Design Patterns for Securing LLM Agents against Prompt Injections](https://mlsanity.com/paper/2506.08837/) (2025)
- [DRIFT: Dynamic Rule-Based Defense with Injection Isolation for Securing LLM Agents](https://mlsanity.com/paper/2506.12104/) (2025)
- [ACE: A Security Architecture for LLM-Integrated App Systems](https://mlsanity.com/paper/2504.20984/) (2025)
- [Operationalizing a Threat Model for Red-Teaming Large Language Models (LLMs)](https://mlsanity.com/paper/2407.14937/) (2024)
- [AgentArmor: Enforcing Program Analysis on Agent Runtime Trace to Defend Against Prompt Injection](https://mlsanity.com/paper/2508.01249/) (2025)
- [AttriGuard: Defeating Indirect Prompt Injection in LLM Agents via Causal Attribution of Tool Invocations](https://mlsanity.com/paper/2603.10749/) (2026)
- [Towards Verifiably Safe Tool Use for LLM Agents](https://mlsanity.com/paper/2601.08012/) (2026)
- [Defending Against Prompt Injection with DataFilter](https://mlsanity.com/paper/2510.19207/) (2025)
- [Prompt Injection Attacks on Agentic Coding Assistants: A Systematic Analysis of Vulnerabilities in Skills, Tools, and Protocol Ecosystems](https://mlsanity.com/paper/2601.17548/) (2026)
- [LLM Agents Should Employ Security Principles](https://mlsanity.com/paper/2505.24019/) (2025)
- [Agentic AI Security: Threats, Defenses, Evaluation, and Open Challenges](https://mlsanity.com/paper/2510.23883/) (2025)
- [A Survey on Long-Term Memory Security in LLM Agents: Attacks, Defenses, and Governance Across the Memory Lifecycle](https://mlsanity.com/paper/2604.16548/) (2026)
- [BrowseSafe: Understanding and Preventing Prompt Injection Within AI Browser Agents](https://mlsanity.com/paper/2511.20597/) (2025)
- [GoEX: Perspectives and Designs Towards a Runtime for Autonomous LLM Applications](https://mlsanity.com/paper/2404.06921/) (2024)
- [Les Dissonances: Cross-Tool Harvesting and Polluting in Pool-of-Tools Empowered LLM Agents](https://mlsanity.com/paper/2504.03111/) (2025)
- [Towards Automating Data Access Permissions in AI Agents](https://mlsanity.com/paper/2511.17959/) (2025)
- [From Storage to Steering: Memory Control Flow Attacks on LLM Agents](https://mlsanity.com/paper/2603.15125/) (2026)
- [How Your Credentials Are Leaked by LLM Agent Skills: An Empirical Study](https://mlsanity.com/paper/2604.03070/) (2026)
- [Indirect Prompt Injections: Are Firewalls All You Need, or Stronger Benchmarks?](https://mlsanity.com/paper/2510.05244/) (2025)
- [CaMeLs Can Use Computers Too: System-level Security for Computer Use Agents](https://mlsanity.com/paper/2601.09923/) (2026)
- [A Framework for Formalizing LLM Agent Security](https://mlsanity.com/paper/2603.19469/) (2026)
- [Agent-Sentry: Bounding LLM Agents via Execution Provenance](https://mlsanity.com/paper/2603.22868/) (2026)
- [Aligning Provenance with Authorization: A Dual-Graph Defense for LLM Agents](https://mlsanity.com/paper/2605.26497/) (2026)
- [ARGUS: Defending LLM Agents Against Context-Aware Prompt Injection](https://mlsanity.com/paper/2605.03378/) (2026)
- [Breaking and Fixing Defenses Against Control-Flow Hijacking in Multi-Agent Systems](https://mlsanity.com/paper/2510.17276/) (2025)
- [Secure and Efficient Access Control for Computer-Use Agents via Context Space](https://mlsanity.com/paper/2509.22256/) (2025)
- [SoK: Trust-Authorization Mismatch in LLM Agent Interactions](https://mlsanity.com/paper/2512.06914/) (2025)

## Abstract (arXiv)

Large language models (LLMs) extended as systems, such as ChatGPT, have begun supporting third-party applications. These LLM apps leverage the de facto natural language-based automated execution paradigm of LLMs: that is, apps and their interactions are defined in natural language, provided access to user data, and allowed to freely interact with each other and the system. These LLM app ecosystems resemble the settings of earlier computing platforms, where there was insufficient isolation between apps and the system. Because third-party apps may not be trustworthy, and exacerbated by the imprecision of natural language interfaces, the current designs pose security and privacy risks for users. In this paper, we evaluate whether these issues can be addressed through execution isolation and what that isolation might look like in the context of LLM-based systems, where there are arbitrary natural language-based interactions between system components, between LLM and apps, and between apps. To that end, we propose IsolateGPT, a design architecture that demonstrates the feasibility of execution isolation and provides a blueprint for implementing isolation, in LLM-based systems. We evaluate IsolateGPT against a number of attacks and demonstrate that it protects against many security, privacy, and safety issues that exist in non-isolated LLM-based systems, without any loss of functionality. The performance overhead incurred by IsolateGPT to improve security is under 30% for three-quarters of tested queries.