# MedMamba: Vision Mamba for Medical Image Classification

arXiv: https://arxiv.org/abs/2403.03849 · HTML: https://mlsanity.com/paper/2403.03849/

## Key facts

- Cited by 88 papers in the map (data through 14 Oct 2026).
- Placed in Mamba for medical image analysis, one of 10 directions in State-space sequence models (S4, Mamba).
- Builds on 20 of its 36 references that are in the map.
- First posted on arXiv 6 Mar 2024.

## Placed in

- State-space sequence models (S4, Mamba) / [Mamba for medical image analysis](https://mlsanity.com/ssm/mamba-for-medical-image-analysis/)

## Builds on (most cited first, 20 of 20)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [Mask R-CNN](https://mlsanity.com/paper/1703.06870/) (2017)
- [Layer Normalization](https://mlsanity.com/paper/1607.06450/) (2016)
- [You Only Look Once: Unified, Real-Time Object Detection](https://mlsanity.com/paper/1506.02640/) (2015)
- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [A ConvNet for the 2020s](https://mlsanity.com/paper/2201.03545/) (2022)
- [Efficiently Modeling Long Sequences with Structured State Spaces](https://mlsanity.com/paper/2111.00396/) (2021)
- [Searching for MobileNetV3](https://mlsanity.com/paper/1905.02244/) (2019)
- [EfficientNetV2: Smaller Models and Faster Training](https://mlsanity.com/paper/2104.00298/) (2021)
- [Vision Mamba: Efficient Visual Representation Learning with Bidirectional State Space Model](https://mlsanity.com/paper/2401.09417/) (2024)
- [VMamba: Visual State Space Model](https://mlsanity.com/paper/2401.10166/) (2024)
- [Sigmoid-Weighted Linear Units for Neural Network Function Approximation in Reinforcement Learning](https://mlsanity.com/paper/1702.03118/) (2017)
- [U-Mamba: Enhancing Long-range Dependency for Biomedical Image Segmentation](https://mlsanity.com/paper/2401.04722/) (2024)
- [VM-UNet: Vision Mamba UNet for Medical Image Segmentation](https://mlsanity.com/paper/2402.02491/) (2024)
- [Recent advances and clinical applications of deep learning in medical image analysis](https://mlsanity.com/paper/2105.13381/) (2021)
- [ColorNet: Investigating the importance of color spaces for image classification](https://mlsanity.com/paper/1902.00267/) (2019)
- [A Comprehensive Study of Vision Transformers in Image Classification Tasks](https://mlsanity.com/paper/2312.01232/) (2023)

## Built on by (most cited first, 30 of 88)

- [Mamba-360: Survey of State Space Models as Transformer Alternative for Long Sequence Modelling: Methods, Applications, and Challenges](https://mlsanity.com/paper/2404.16112/) (2024)
- [State Space Model for New-Generation Network Alternative to Transformers: A Survey](https://mlsanity.com/paper/2404.09516/) (2024)
- [Vision Mamba: A Comprehensive Survey and Taxonomy](https://mlsanity.com/paper/2405.04404/) (2024)
- [A Survey on Visual Mamba](https://mlsanity.com/paper/2404.15956/) (2024)
- [Visual Mamba: A Survey and New Outlooks](https://mlsanity.com/paper/2404.18861/) (2024)
- [Spatial-Mamba: Effective Visual State Space Models via Structure-aware State Fusion](https://mlsanity.com/paper/2410.15091/) (2024)
- [I2I-Mamba: Multi-modal medical image synthesis via selective state space modeling](https://mlsanity.com/paper/2405.14022/) (2024)
- [Mambular: A Sequential Model for Tabular Deep Learning](https://mlsanity.com/paper/2408.06291/) (2024)
- [Mamba in Vision: A Comprehensive Survey of Techniques and Applications](https://mlsanity.com/paper/2410.03105/) (2024)
- [A Comprehensive Survey of Mamba Architectures for Medical Image Analysis: Classification, Segmentation, Restoration and Beyond](https://mlsanity.com/paper/2410.02362/) (2024)
- [AVS-Mamba: Exploring Temporal and Multi-modal Mamba for Audio-Visual Segmentation](https://mlsanity.com/paper/2501.07810/) (2025)
- [MMR-Mamba: Multi-Modal MRI Reconstruction with Mamba and Spatial-Frequency Information Fusion](https://mlsanity.com/paper/2406.18950/) (2024)
- [SliceMamba with Neural Architecture Search for Medical Image Segmentation](https://mlsanity.com/paper/2407.08481/) (2024)
- [DenoMamba: A fused state-space model for low-dose CT denoising](https://mlsanity.com/paper/2409.13094/) (2024)
- [Evolving Medical Imaging Agents via Experience-driven Self-skill Discovery](https://mlsanity.com/paper/2603.05860/) (2026)
- [A Survey on Mamba Architecture for Vision Applications](https://mlsanity.com/paper/2502.07161/) (2025)
- [ms-Mamba: Multi-scale Mamba for Time-Series Forecasting](https://mlsanity.com/paper/2504.07654/) (2025)
- [HSIDMamba: Exploring Bidirectional State-Space Models for Hyperspectral Denoising](https://mlsanity.com/paper/2404.09697/) (2024)
- [FER-YOLO-Mamba: Facial Expression Detection and Classification Based on Selective State Space](https://mlsanity.com/paper/2405.01828/) (2024)
- [MambaRecon: MRI Reconstruction with Structured State Space Models](https://mlsanity.com/paper/2409.12401/) (2024)
- [Mamba-Sea: A Mamba-based Framework with Global-to-Local Sequence Augmentation for Generalizable Medical Image Segmentation](https://mlsanity.com/paper/2504.17515/) (2025)
- [Retinex-RAWMamba: Bridging Demosaicing and Denoising for Low-Light RAW Image Enhancement](https://mlsanity.com/paper/2409.07040/) (2024)
- [XFMamba: Cross-Fusion Mamba for Multi-View Medical Image Classification](https://mlsanity.com/paper/2503.02619/) (2025)
- [VasTSD: Learning 3D Vascular Tree-state Space Diffusion Model for Angiography Synthesis](https://mlsanity.com/paper/2503.12758/) (2025)
- [MambaCapsule: Towards Transparent Cardiac Disease Diagnosis with Electrocardiography Using Mamba Capsule Network](https://mlsanity.com/paper/2407.20893/) (2024)
- [Enhancing Fetal Plane Classification Accuracy with Data Augmentation Using Diffusion Models](https://mlsanity.com/paper/2501.15248/) (2025)
- [Medical Image Classification with KAN-Integrated Transformers and Dilated Neighborhood Attention](https://mlsanity.com/paper/2502.13693/) (2025)
- [RAM-W600: A Multi-Task Wrist Dataset and Benchmark for Rheumatoid Arthritis](https://mlsanity.com/paper/2507.05193/) (2025)
- [Monocular Visual Place Recognition in LiDAR Maps via Cross-Modal State Space Model and Multi-View Matching](https://mlsanity.com/paper/2410.06285/) (2024)
- [START: A Generalized State Space Model with Saliency-Driven Token-Aware Transformation](https://mlsanity.com/paper/2410.16020/) (2024)

## Abstract (arXiv)

Since the era of deep learning, convolutional neural networks (CNNs) and vision transformers (ViTs) have been extensively studied and widely used in medical image classification tasks. Unfortunately, CNN's limitations in modeling long-range dependencies result in poor classification performances. In contrast, ViTs are hampered by the quadratic computational complexity of their self-attention mechanism, making them difficult to deploy in real-world settings with limited computational resources. Recent studies have shown that state space models (SSMs) represented by Mamba can effectively model long-range dependencies while maintaining linear computational complexity. Inspired by it, we proposed MedMamba, the first Vision Mamba for generalized medical image classification. Concretely, we introduced a novel hybrid basic block named SS-Conv-SSM, which purely integrates the convolutional layers for extracting local features with the abilities of SSM to capture long-range dependencies, aiming to model medical images from different image modalities efficiently. By employing the grouped convolution strategy and channel-shuffle operation, MedMamba successfully provides fewer model parameters and a lower computational burden for efficient applications without sacrificing accuracy. We thoroughly evaluated MedMamba using 16 datasets containing ten imaging modalities and 411,007 images. Experimental results show that MedMamba demonstrates competitive performance on most tasks compared with the state-of-the-art methods. This work aims to explore the potential of Vision Mamba and establish a new baseline for medical image classification, thereby providing valuable insights for developing more powerful Mamba-based artificial intelligence algorithms and applications in medicine. The source codes and all pre-trained weights of MedMamba are available at https://github.com/YubiaoYue/MedMamba.