# Zero-Shot Pediatric Tuberculosis Detection in Chest X-Rays using Self-Supervised Learning

arXiv: https://arxiv.org/abs/2402.14741 · HTML: https://mlsanity.com/paper/2402.14741/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 15 of its 35 references that are in the map.
- First posted on arXiv 22 Feb 2024.

## Builds on (most cited first, 15 of 15)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [An Empirical Study of Training Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.02057/) (2021)
- [CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparison](https://mlsanity.com/paper/1901.07031/) (2019)
- [ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases](https://mlsanity.com/paper/1705.02315/) (2017)
- [COVID-Net: A Tailored Deep Convolutional Neural Network Design for Detection of COVID-19 Cases from Chest X-Ray Images](https://mlsanity.com/paper/2003.09871/) (2020)
- [AI can evolve without labels: self-evolving vision transformer for chest X-ray diagnosis through knowledge distillation](https://mlsanity.com/paper/2202.06431/) (2022)
- [Self-supervised deep convolutional neural network for chest X-ray classification](https://mlsanity.com/paper/2103.03055/) (2021)
- [Abnormality Detection and Localization in Chest X-Rays using Deep Convolutional Neural Networks](https://mlsanity.com/paper/1705.09850/) (2017)
- [COVIDx CXR-3: A Large-Scale, Open-Source Benchmark Dataset of Chest X-ray Images for Computer-Aided COVID-19 Diagnostics](https://mlsanity.com/paper/2206.03671/) (2022)
- [TB-Net: A Tailored, Self-Attention Deep Convolutional Neural Network Design for Detection of Tuberculosis Cases from Chest X-ray Images](https://mlsanity.com/paper/2104.03165/) (2021)
- [SPCXR: Self-supervised Pretraining using Chest X-rays Towards a Domain Specific Foundation Model](https://mlsanity.com/paper/2211.12944/) (2022)
- [A Lightweight, Rapid and Efficient Deep Convolutional Network for Chest X-Ray Tuberculosis Detection](https://mlsanity.com/paper/2309.02140/) (2023)

## Built on by (most cited first, 1 of 1)

- [Prompt as Knowledge Bank: Boost Vision-language model via Structural Representation for zero-shot medical detection](https://mlsanity.com/paper/2502.16223/) (2025)

## Abstract (arXiv)

Tuberculosis (TB) remains a significant global health challenge, with pediatric cases posing a major concern. The World Health Organization (WHO) advocates for chest X-rays (CXRs) for TB screening. However, visual interpretation by radiologists can be subjective, time-consuming and prone to error, especially in pediatric TB. Artificial intelligence (AI)-driven computer-aided detection (CAD) tools, especially those utilizing deep learning, show promise in enhancing lung disease detection. However, challenges include data scarcity and lack of generalizability. In this context, we propose a novel self-supervised paradigm leveraging Vision Transformers (ViT) for improved TB detection in CXR, enabling zero-shot pediatric TB detection. We demonstrate improvements in TB detection performance (~12.7% and ~13.4% top AUC/AUPR gains in adults and children, respectively) when conducting self-supervised pre-training when compared to fully-supervised (i.e., non pre-trained) ViT models, achieving top performances of 0.959 AUC and 0.962 AUPR in adult TB detection, and 0.697 AUC and 0.607 AUPR in zero-shot pediatric TB detection. As a result, this work demonstrates that self-supervised learning on adult CXRs effectively extends to challenging downstream tasks such as pediatric TB detection, where data are scarce.