# Cas-DiffCom: Cascaded diffusion model for infant longitudinal super-resolution 3D medical image completion

arXiv: https://arxiv.org/abs/2402.13776 · HTML: https://mlsanity.com/paper/2402.13776/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 5 of its 13 references that are in the map.
- First posted on arXiv 21 Feb 2024.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 5 of 5)

- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Cascaded Diffusion Models for High Fidelity Image Generation](https://mlsanity.com/paper/2106.15282/) (2021)
- [MM-Diffusion: Learning Multi-Modal Diffusion Models for Joint Audio and Video Generation](https://mlsanity.com/paper/2212.09478/) (2022)
- [A Novel Unified Conditional Score-based Generative Framework for Multi-modal Medical Image Completion](https://mlsanity.com/paper/2207.03430/) (2022)

## Built on by (most cited first, 4 of 4)

- [OmniSSR: Zero-shot Omnidirectional Image Super-Resolution using Stable Diffusion Model](https://mlsanity.com/paper/2404.10312/) (2024)
- [LoCI-DiffCom: Longitudinal Consistency-Informed Diffusion Model for 3D Infant Brain Image Completion](https://mlsanity.com/paper/2405.10691/) (2024)
- [Trustworthy Longitudinal Brain MRI Completion: A Deformation-Based Approach with KAN-Enhanced Diffusion Model](https://mlsanity.com/paper/2601.09572/) (2026)
- [Diffusion Models in Medical Image Inpainting: Challenges, Solution Taxonomy, and Future Directions](https://mlsanity.com/paper/2607.21904/) (2026)

## Abstract (arXiv)

Early infancy is a rapid and dynamic neurodevelopmental period for behavior and neurocognition. Longitudinal magnetic resonance imaging (MRI) is an effective tool to investigate such a crucial stage by capturing the developmental trajectories of the brain structures. However, longitudinal MRI acquisition always meets a serious data-missing problem due to participant dropout and failed scans, making longitudinal infant brain atlas construction and developmental trajectory delineation quite challenging. Thanks to the development of an AI-based generative model, neuroimage completion has become a powerful technique to retain as much available data as possible. However, current image completion methods usually suffer from inconsistency within each individual subject in the time dimension, compromising the overall quality. To solve this problem, our paper proposed a two-stage cascaded diffusion model, Cas-DiffCom, for dense and longitudinal 3D infant brain MRI completion and super-resolution. We applied our proposed method to the Baby Connectome Project (BCP) dataset. The experiment results validate that Cas-DiffCom achieves both individual consistency and high fidelity in longitudinal infant brain image completion. We further applied the generated infant brain images to two downstream tasks, brain tissue segmentation and developmental trajectory delineation, to declare its task-oriented potential in the neuroscience field.